Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Adaptive Designs"”.
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Adaptive designs for complex dose finding studies
… toxicity or (and) efficacy characteristics. Designs for trials studying doses of a single cytotoxic drug are based on the fundamental assumption "the more the better", that is, the toxicity and efficacy increase with the dose. This monotonicity assumption can be violated for novel therapies …
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Bayesian Adaptive Designs For Early Phase Clinical Trials
<p>My dissertation focuses mainly on Bayesian adaptive designs for phase I and phase II clinical trials. It includes three specific topics: <strong>(1)</strong> proposing a novel two-dimensional dose-finding algorithm for biological agents, <strong>(2)</strong> developing Bayesian adaptive …
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Bayesian Adaptive Designs for Early Phase Clinical Trials
… the operating characteristics of the proposed designs through simulation studies and compare them to existing methods. The umbrella trial is a clinical trial strategy that accommodates the paradigm shift towards personalized medicine, which evaluates multiple investigational drugs in different …
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Adaptive Designs and Methods for More Efficient Drug Development
… and expensive process. Innovative trial designs and optimal sequences of clinical trials aim to increase the efficiency of this process by improving flexibility and maximising the use of accumulated information throughout the trials while minimizing the number of patients that are exposed …
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Bayesian adaptive designs for non-inferiority and dose selection trials.
… admit ease of interpretation. Bayesian adaptive sampling methods offer the potential to accelerate the investigation of a drug without compromising the safety of the trial's participants. These methods select a patient's treatment based upon prior information and the knowledge accrued …
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Bayesian Adaptive Designs For Proof-of-Concept Trials and Platform Trials
… It’s crucial to develop novel phase II trial designs to accomplish different objectives for different types of trials. This research mainly focuses on Bayesian adaptive designs for phase II trials. Three types of trials are discussed in which traditional designs may encounter limitations, and …
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Bayesian Adaptive Designs and Versatile Software Platform For Early Phase Clinical Trials
… dedicated to improve the efficiency of Bayesian adaptive designs for early phase clinical trials. Phase I clinical trials can be conducted using algorithm-based (also known as rule-based), model-based, or model-assisted designs. Numerous studies have shown that model-assisted designs have the …
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The Impact of “Multiple Looks” when Performing Survival Analysis
… methodology in health care is the practice of adaptive designs. Adaptive designs allow for interim analyses to take place during a study and various decisions and actions can take place more ethically. This is beneficial for studies that take multiple years to complete and allows administrators …
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Bayesian approaches for survival data in pharmaceutical research.
… in network meta-analysis, prior elicitation, and adaptive designs. Network meta-analysis is a hierarchical model used to combine the results of multiple studies, and allows for us to make direct and indirect comparisons between treatments. We investigate Bayesian network meta-analysis models for …
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Methods for Comparing Two Means with Application in Adaptive Clinical Trials
… Also, in recent years, the use of sequential and adaptive design methods in clinical research and development based on accrued data has become very popular due to its flexibility and efficiency. In this thesis, we derive the Behrens-Fisher distribution, and use the distributional result to examine …
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Adaptive design of clinical trials : understanding the barriers to adoption
… in a growing trend for clinical research to use adaptive design models to accelerate clinical trials and at the same time reduce overall cost. Although such models have existed for several years, the pace of adoption remains slow, especially for early-stage clinical research. Through a review of …
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Response Adaptive Design using Auxiliary and Primary Outcomes
Response adaptive designs intend to allocate more patients to better treatments without undermining the validity and the integrity of the trial. The immediacy of the primary response (e.g. deaths, remission) determines the efficiency of the response adaptive design, which often requires outcomes to …
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Topics in Bayesian adaptive clinical trial design using dynamic linear models and missing data imputation in logistic regression.
Conventional Phase II clinical trial designs usually employ a logistic regression model to analyze the efficacy of a new drug and, therefore, assumes monotone dose-response relationship. Also, the logistic regression model requires the response to be categorical and, thus, it is not applicable for …
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Algorithmic Approaches to Nonparametric Causal Inference
… observational studies, completely randomized designs, paired experiments, and covariate-adaptive designs. First, we discuss an application of convex optimization to conduct directional inference and sensitivity analyses in matched observational studies. We design an algorithm which maximizes …
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Exploring Support for Knowledge Utilisation: Decision Making in Complex Interdisciplinary Engineering Systems
… for innovation in organisations that use adaptive designs that have a high level of complexity. Many managers are concerned about the future impact. Documentation and digital resources are used as a primary coping mechanism. Although engineers recognise the considerable benefits from …
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BLINDED EVALUATIONS OF EFFECT SIZES IN CLINICAL TRIALS: COMPARISONS BETWEEN BAYESIAN AND EM ANALYSES
… endpoints. The 2010 draft FDA guidance on adaptive designs acknowledges possible study design modifications, such as selection and/or order of secondary endpoints, in addition to sample size re-estimation. It is essential for the integrity of a double-blind clinical trial that individual …
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Innovative Methods for the Design and Analysis of Phase II Clinical Trials
… potential for improving clinical trial designs, particularly for phase II trials, which play a critical role in the drug development process. Innovative methods are especially necessary for addressing key challenges in phase II trials in terms of dose-ranging study, patient population …
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Bayesian Semi-Mechanistic Dose-Finding Designs For Phase I Oncology Trials
<p>Bayesian adaptive designs are getting more popular in research and in practice because they are flexible and efficient in evaluating an experimental drug. In oncology, despite the great advances in novel dose-finding designs, the high failure rates of clinical cancer drug development from phase …
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The application of Bayesian adaptive design and Markov model in clinical trials
In this research, two new designs in clinical trials are proposed. The first problem is a new Bayesian adaptive dose-finding design and its application in an oncology clinical trial. This design is used for phase IB studies with the biomarker as the endpoint and with the fewer patients. The second …
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