Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 50 for “"Adaptive Design"”.
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Sequential optimization through adaptive design of experiments
… of achieving better system performance through adaptive experiments. For the case of discrete design space, I propose an adaptive One-Factor-at-A-Time (OFAT) experimental design, study its properties and compare its performance to saturated fractional factorial designs. The rationale for …
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Response Adaptive Design using Auxiliary and Primary Outcomes
Response adaptive designs intend to allocate more patients to better treatments without undermining the validity and the integrity of the trial. The immediacy of the primary response (e.g. deaths, remission) determines the efficiency of the response adaptive design, which often requires outcomes to …
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Adaptive design of clinical trials : understanding the barriers to adoption
… in a growing trend for clinical research to use adaptive design models to accelerate clinical trials and at the same time reduce overall cost. Although such models have existed for several years, the pace of adoption remains slow, especially for early-stage clinical research. Through a review of …
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Stakeholder collaboration in Air Force acquisition : adaptive design using system representations
… to adapt a weapon system while it is still being designed affords a means to respond to this complexity. The fundamental motivation for this research is to discover how Air Force development programs, operating within established constraints, can improve their adaptability during the design phase …
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Learning-based adaptive design for dynamic spectrum access in cognitive radio networks.
… cognitive radio networks. The main objective is designing online learning and access policies which maximize the total throughput of the secondary users in a cognitive radio network. As the first approach, we consider the auction-based formulation in design of dynamic spectrum access mechanisms …
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The application of Bayesian adaptive design and Markov model in clinical trials
In this research, two new designs in clinical trials are proposed. The first problem is a new Bayesian adaptive dose-finding design and its application in an oncology clinical trial. This design is used for phase IB studies with the biomarker as the endpoint and with the fewer patients. The second …
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Addressing deep uncertainty in space system development through model-based adaptive design
… a space system, many properties of the design space are initially unknown and are discovered during the development process. Therefore, the problem exhibits deep uncertainty. Deep uncertainty refers to the condition where the full range of outcomes of a decision is not knowable. A key …
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Bayesian sample-size determination and adaptive design for clinical trials with Poisson outcomes.
… for a parameter of interest or need to adaptive design elements during the course of the trial based on information that is initially unknown. Although most experimenters have employed frequentist methods, the Bayesian paradigm offers a wide variety of methodologies and are becoming …
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Development of a Design Tool for Biologically Inspired Fault Adaptive Design by Strategy Mapping
<p>A design tool for Biologically Inspired Fault Adaption that utilizes the concept of strategy mapping was developed and the development process and testing is presented in this paper. The concept of strategy mapping is derived primarily from the field of military theory and supposes that for any …
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Efficient computer experiment designs for Gaussian process surrogates
… GP modeling when data abounds as well as GP adaptive design when simulator expense severely limits the amount of collected data. For data-rich problems, I introduce a localized sparse covariance GP that preserves the flexibility and predictive accuracy of a GP's predictive surface while …
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An Adaptive Bayesian Approach to Bernoulli-Response Clinical Trials
… Bernoulli-response clinical trials. A Bayesian adaptive design is used to fit the logistic equation to the dose-response curve of Phase II and Phase III clinical trials. Because of inherent restrictions in the logistic model, symmetric candidate densities cannot be used, thereby creating …
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Adaptation and adaptability : expectant design for resilience in coastal urbanity
… and function therein. Building on a history of adaptive design and natural hazards research, expectant design uses concepts of specificity, incrementality, participation, and phasing in design for urban adaptability. Expectant design employs flexible architectural and urbanistic strategies in …
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The Archipelagian Approach to DSS prototyping: an empirical study
… Approach, a proposed methodology for designing and implementing Decision Support Systems (DSS), attempts to integrate modular design and adaptive design. The approach is based on decomposing the proposed system's tasks into structured and nonstructured modules, evaluating the …
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Topics in Bayesian adaptive clinical trial design using dynamic linear models and missing data imputation in logistic regression.
Conventional Phase II clinical trial designs usually employ a logistic regression model to analyze the efficacy of a new drug and, therefore, assumes monotone dose-response relationship. Also, the logistic regression model requires the response to be categorical and, thus, it is not applicable for …
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A hybrid framework for the design of production systems combining simulation and optimisation methods
… to improve Industry 4.0 capability, digitalised design methods and solutions need to be more integrated and self-adaptive. However, current approaches for production design methods that can provide adaptive design and planning for manufacturing systems in line with the challenges in Industry …
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Methods for Comparing Two Means with Application in Adaptive Clinical Trials
In the design of a clinical trial, the study of the effect of an intervention for a given medical condition is frequently of interest to researcher. Also, in recent years, the use of sequential and adaptive design methods in clinical research and development based on accrued data has become very …
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Implicit pen annotation assisted by Large Language Models
… missed opportunities for more intelligent, adaptive design. This work introduces AnnotateGPT, a document annotation tool with a digital pen. It leverages a Large Language Model (LLM) (1) to infer the underlying purposes of the user’s annotations and (2) automatically generates annotations …
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Adaptable architecture : a computational exploration into responsive design systems
… things, the crystallization of a mediation among design intentions (function), meaning and contextual constraints (performance), we as designers are obligated to produce morphologically flexible & adaptive design solutions; both during the design process and as a final outcome. In that sense this …
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Evaluating next-generation environmental policy tools : adaptive management in the Bureau of Land Management
… (BLM) has begun to embrace the concept adaptive management as an alternative to traditional natural resource planning and management models. Adaptive management may provide BLM managers with a means to evaluate the effectiveness of management actions, the flexibility to adjust actions …
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Falling isn't the End: Reimagining Demolition as a Creative Practice
… and cultural systems, relegating resilient design to the periphery or diminishing its potential impact. Collapse, traditionally perceived as failure, is reimagined here as a generative moment—an opportunity to rethink materials, systems, and the narratives that shape them. Central to this …
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