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Showing 1 to 20 of 21 for “"Adamantane"”.
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Spin dynamics in solids
… reports unusually fast 13C spin diffusion in adamantane. A calculation of the 13C spin-diffusion rate from first order perturbation theory is presented and compared to the experimental data. There is good agreement between calculation and experiment for relatively small mixing times. Motional …
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Remote plasma assisted fabrication of functional organic and hybrid thin films and supported nanostructures
… and ¿Wetting and anti-freezing properties of adamantane coatings: from thin films to 3D networks¿) study the processability and applications of organic thin films as coatings through its functionalities. These films are fabricated from a precursor of adamantane (C10H16) by RPAVD technique. …
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Design and Assembly of Block Copolymer-Modified Nanoparticles into Supracolloidal, Molecular Mimics
… interactions between β-cyclodextrin and adamantane as the host and guest molecules. Upon the slow addition of water, particles assemble due to the host–guest interactions between the complementary block copolymers, as the hydrophobic adamantane moieties are driven within the …
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Covalent Modification that Enhances Protein Properties and Functions and Folds Random Coil into Alpha-Helix
… describes the synthesis and development of an adamantane-platinum conjugate (analog of carboplatin) hosted in beta-cyclodextrin. This inclusion complex formed by betaCD and the adamantane-platinum conjugate exhibited higher cytotoxicity towards neurobalstoma (SK-N-SH) cells than carboplatin. …
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Antiviral polymeric drugs and surface coatings
… was also employed to restore inhibition for the adamantane class of influenza inhibitors against drug-resistant strains. The chemical modifications to the adamantane scaffold necessary for polymer attachment imposed deleterious steric constraints which resulted in poorer inhibitory effect. Even …
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Impact of Post-Synthesis Modification of Nanoporous Organic Frameworks on Selective Carbon Dioxide Capture
… reaction of 1,3,5,7-tetrakis(4-acetylphenyl)adamantane in Ethanol/Xylenes mixture using SiCl4 as a catalyst. NPOF-4 is microporous and has high surface area (SABET = 1249 m2 g-1). Post-synthesis modification of NPOF-4 by nitration afforded (NPOF-4-NO2) and subsequent reduction resulted in an …
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Electrochemical Transformation of Alkanes, Carbon Dioxide and Protons at Iron-Porphyrins and Iron-Sulfur Clusters
… anodic oxidation of hydrocarbons, specifically adamantane hydroxylation and cyclooctene epoxidation. The electrocatalytic and chemical catalytic activity oxidation of the thiolate porphyrins are benchmarked against Fe (III) tetraphenyl porphyrin chloride and its tetrapentafluorophenyl analogue. …
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Structure and function of the Influenza membrane protein M2 by magic angle spinning NMR and dynamic nuclear polarization
… proton transporter that is the target of adamantane based inhibitors but which is now drug resistant due primarily to the point mutation S31N. The development of techniques that boost the sensitivity of NMR are key to its extension to larger molecules such as membrane proteins, and two …
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Injectable supramolecular hydrogels for insulin delivery
… hydrogels created from cyclodextrin-adamantane mediated dynamic crosslinking of hyaluronic acid and show that these hydrogels can form an injectable depot in vivo. We further demonstrate that by changing the molecular weight and concentration of the individual polymers, release both …
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Studies of liquid phase intermolecular interactions utilizing ¹H and ¹³C dynamic nuclear polarization and nuclear magnetic resonance techniques
… the free radical. The solution ¹³C DNP result of adamantane indicates that the DNP enhancements and thus the correlation times for the two different carbon sites are very close under the high free radical concentration. The ¹³C DNP study of C₇₀ empty cage fullerene suggests that the endcap carbons …
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Synthesis, Fractionation, Characterisation and Toxicity of Naphthenic Acids from Complex Mixtures
… acid (IC50 0.7 mM) had the lowest toxicity, adamantane-type acids were the least toxic as a group overall. Conversely, the decahydronaphthalene (decalin)-type acids had the largest range of toxicities (IC50 0.004 to 0.3 mM) and the most toxic acid assayed was 3-decalin-1-yl-propanoic acid. …
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Development of orthogonally crosslinked thiol-ene hydrogels for encapsulation of pancreatic beta-cells
… for soluble guest molecule poly(ethylene glycol)-adamantane. Gel stiffness was tuned through introducing reversible host-guest interactions. After <em>in situ</em> stiffening of the cell-laden hydrogel, the encapsulated β-cells showed increased in insulin mRNA expression, suggesting the profound …
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Utilisation des diazirines comme source d'azote électrophile pour la synthèse d'hydrazines et d'hétérocycles
… étudie le potentiel électrophile de la diazirine adamantane par des réactions d’addition nucléophile. Dépendamment du composé additionné, les produits obtenus sont les diaziridines ou les hydrazones monosubstituées. L’hydrolyse de ces dernières molécules étant difficiles, l’obtention directe des …
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The role of sphingosine kinases and dihydroceramide desaturase in regulating senescence in prostate cancer cells
… 2 inhibitor, ABC294640 (3-(4-chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide), which is currently in phase 2 clinical trials for renal cancer and B-cell lymphoma, induces the proteasomal degradation of sphingosine kinase 1; therefore ABC294640 cannot be considered an SK2 …
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Synthesis, Monitoring, and Molechanical Action of Light-Driven Motorized Nanomachines
… includes a fast rotary light-driven motor, four adamantane wheels, and BODIPY fluorophores for their tracking by Single-Molecule Fluorescence Spectroscopy (SMFM). Through a series of iterations, the nanocars were optimized such that the motor keeps its fast rotation frequency in the presence of …
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Synthesis of Highly Ordered Polymer Nanostructures Based on Polyphenylene Vinylenes (PPVs)
… or tetraethylene glycol) or rigid linkers (adamantane, diamantane, or azobenzene) were created. Depending on the structure of the PPV chromophore, variations in the polymer chain morphology was found as evident by thin film and single molecule morphology modulation. Thin film fluorescence …
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Mechanism of Action and Gold Nanoparticle Delivery of Pt(IV) Prodrugs of Cisplatin
… binding to DNA. Another Pt(IV) complex, 1-adamantanemethylamine-Pt(IV), <strong>4</strong>, which is also a potential prodrug of cisplatin was synthesized by tethering 1-adamantanemethylamine to oxoplatin using a dicarboxylate linker. To achieve higher anticancer activity and better …
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The role of sphingosine kinases and dihydroceramide desaturase in cell survival/apoptosis and inflammation pathways
… kinase inhibitor, ABC294640 [3-(4- chlorophenyl)-adamantane-1-carboxylic acid (pyridin-4-ylmethyl)amide] (25 to 50 μM), did not promote formation of polyubiquitinated Degs1 forms and induced apoptosis of HEK293T cells via a mechanism involving native Degs1. Native Degs1 appears to function in this …
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Binary diamondoid molecular gels
… mixing dimethyl sulfoxide (DMSO) solutions of 1-adamantanecarboxylic acid (A1C) with 1-adamantylamine (A1N). Upon mixing at vanishing concentrations, these diamondoid molecules rapidly aggregate. At approximately 3% by weight, the resulting suspension forms a percolated network. These resulting …
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