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Showing 1 to 20 of 86 for “"Acyltransferase"”.
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Effects of Glycosylation on Lecithin -Cholesterol Acyltransferase
LCAT glycosylation mutants N84Q and N384Q were examined to determine the effects of deleting individual glycan chains. Purified N84Q LCAT did not possess measurable enzymatic activity or interfacial binding affinity for rHDL. Purified N384Q was more enzymatically active than WT LCAT, but lost all …
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Purification and Properties of Lecithin-Cholesterol Acyltransferase
Made available in DSpace on 2015-05-13T15:27:03Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 8203445.PDF: 3614579 bytes, checksum: bda8ab98d10406393a6bdf5d19af1d37 (MD5) Previous issue date: 1981
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Identification and Biochemical Characterization of Ghrelin O-Acyltransferase (GOAT)
… cloning, I have identified GOAT (Ghrelin O-Acyltransferase), an enzyme belonging to a family of 16 polytopic membrane-bound O-acyltransferases. GOAT activity requires catalytic Asn and His residues, which are conserved through vertebrates. Consistent with its function, GOAT mRNA is largely …
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Specificity of Lecithin-Cholesterol Acyltransferase Toward the Acyl Acceptor
Made available in DSpace on 2015-05-13T15:26:56Z (GMT). No. of bitstreams: 2 license.txt: 4848 bytes, checksum: 96035ab3f5e1c23cc7138a224ce498bd (MD5) 7804114.PDF: 2415008 bytes, checksum: 5b5110964be43ecfb77fd3ca6fdcf678 (MD5) Previous issue date: 1977
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Protein and cell therapy for lecithin-cholesterol acyltransferase (LCAT) deficiency
Lecithin-cholesterol acyltransferase (LCAT) is an enzyme principally secreted by the liver into the circulation where it esterifies cholesterol and plays a key role in high- density lipoprotein (HDL) metabolism. In familial and acquired (liver disease) LCAT deficiency, the failure to esterify …
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Enzymology and inhibition of ghrelin acylation by ghrelin O-acyltransferase
… is catalyzed by the enzyme ghrelin O-acyltransferase (GOAT), a topologically complex integral membrane protein. GOAT is an intriguing target for biochemical studies, as no other enzyme is known to catalyze octanoylation of a serine hydroxyl group. It is also an attractive target for …
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Factors affecting the binding of lecithin:cholesterol acyltransferase with interfacial substrates
… (HDL) catalyzed by lecithin:cholesterol acyltransferase (LCAT) maintains a gradient for cholesterol diffusion from cell membranes and atherosclerotic plaques and plays a critical part in the maintenance of cholesterol homeostasis. The principal protein of HDL, apolipoprotein A-I (apoA-I) …
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Structural and Functional Insights into Ghrelin Acylation by Ghrelin O-Acyltransferase
… modification to be biological active. Ghrelin O-acyltransferase (GOAT) is responsible for catalyzing octanoylation of the 3rd serine side chain of ghrelin to generate the active form of this hormone. Thus, GOAT is considered as a potential therapeutic target for treatment of obesity and other …
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Regulation of Diacylglycerol Acyltransferase-2 and Triacylglycerol Synthesis by Protein Ubiquitination
… synthesis is catalyzed by diacylglycerol acyltransferase (DGAT) enzymes, DGAT1 and DGAT2. Although recent studies have shed light on the metabolic functions of these enzymes, little is known about their regulation. We have found that DGAT2 is a short-lived protein and is degraded via the …
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The Role of Lysophosphatidylcholine Acyltransferase (LPCAT) 3 in Macrophage Inflammatory Responses
… of the host. The Lysophosphatidylcholine acyltransferase (LPCAT) enzymes, expressed in monocytes and macrophages among other cells and tissues have been found to be very important in the regulation of membrane phospholipids’ fatty acid composition and together with phospholipase A2 enzyme, …
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Lysophosphatidylcholine acyltransferase-2 (LPCAT-2) & protein S-acylation in macrophage innate immunity
Lysophosphatidylcholine acyltransferase (LPCAT)2 is an enzyme involved in remodelling glycerophospholipids within cell membranes and the generation of platelet-activating factor. LPCAT2 also mediates lipopolysaccharide (LPS)-induced cytokine responses in both murine and human macrophages. …
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Various Factors Affecting Cholesterol Esterification in Plasma Lipoproteins by Cholesterol-Lecithin Acyltransferase
Made available in DSpace on 2014-12-09T14:36:56Z (GMT). No. of bitstreams: 1 6711908.pdf: 3516717 bytes, checksum: 88d11213c2dde5ec4ec4474cfa409621 (MD5) Previous issue date: 1967
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Factors affecting the reaction of lecithin cholesterol acyltransferase with water-soluble substrates
Restriction data tranferred 2014-07-01T11:22:48-05:00 Original Data Group with Access UIUC Users [automated] Release Date: none Reason: ETDs are only available to UIUC Users without author permission
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Roles of Phospholipase A/Acyltransferase Enzymes in Membrane Remodelling and Organelle Degradation
… is coordinated by phospholipase A (PLA) and acyltransferases (AT). PLA/AT are a family of 5 enzymes evolutionarily conserved in vertebrates. Recently, they have been implicated in processes from organelle degradation during lens differentiation to host immune responses against Toxoplasma …
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Acyltransferase LovD as a Simvastatin Synthase: Mutational Deconvolution, Design, Substrate Scope and Immobilization
… this doctoral thesis, a systematic study of the acyltransferase enzyme LovD from the fungus Aspergillus terreus, which was previously modified by directed evolution for the improved production of the anti-cholesterol drug simvastatin from monacolinic acid J, is performed. First, an analysis of …
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Effect of Lecithin on the Esterification of Lipoprotein Cholesterol by Lecithin-Cholesterol Acyltransferase
Made available in DSpace on 2014-12-13T19:47:49Z (GMT). No. of bitstreams: 1 8026620.pdf: 2603585 bytes, checksum: de4e5562db3f45cfa86bbc78b4ccf72c (MD5) Previous issue date: 1980
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Pre-Clinical Development Of Aav Mediated Gene Therapy For Familial Lecithin Cholesterol Acyltransferase Deficiency
Familial lecithin cholesterol acyltransferase (LCAT) deficiency (FLD), is a rare monogenic disease, characterized by abnormal lipid profile, corneal opacities, anemia and renal disease which progresses to renal failure. There is currently no approved treatment for patients with this disease. FLD is …
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Probing the Structure and Function of Lecithin Cholesterol Acyltransferase by Site-Directed and Deletion Mutagenesis
These results have established further relationships between LCAT and other interfacially activated lipases and have contributed to the understanding of the functional regions of LCAT.
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