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Showing 1 to 20 of 152 for “"Acylation"”.
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Enzymatic acylation of starch
… of other reaction systems for enzymatic starch acylation, revealed nonenzymatic transesterification of vinyl decanoate with starch in DMSO. On the other hand, the ionic liquid 1-ethyl-3-methylimidazolium dicyanamide ([EMIM][DCA]), was a suitable medium for lipase catalysed synthesis of starch …
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Enzymology of DHHC-mediated Protein S-Acylation
Protein <italic>S</italic>-acylation is the post-translational modification of proteins with long-chain fatty acids at cysteine residues via a thioester linkage. The most commonly attached lipid is 16-carbon palmitate, thus the process is often called palmitoylation. Unlike other lipid …
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Alpha-Oxygenation by Acylation-Rearrangement of Nitrones
The acylation-rearrangement of N-alkylnitrones with acid chlorides and triethylamine affords a new method for the (alpha)-oxygenation of aldehydes and cyclic ketones via (alpha)-acyloxy imines. The reaction apparently proceeds by initial acylation of the nitrone oxygen, proton removal, and …
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DNAzymes for sequence-dependent peptide lysine acylation
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2025-10-20 without embargo terms
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DNAzymes for amine and peptide lysine acylation
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2023-12-01
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Investigating The In Vivo Role Of Wnt Acylation
… Wnt proteins which undergo post-translational acylation at a highly-conserved serine residue. All Wnts bind to the Frizzled (Fz) family of seven-pass transmembrane receptor at an extracellular cysteine-rich domain (CRD). Recent crystallographic evidence suggests that interaction between Wnt and …
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Acylation de composés aromatiques catalysée par des catalyseurs hétérogènes
… substitutions électrophiles : l’alkylation et l’acylation d’un composé aromatique. Dans notre cas, la réaction concernée est l’acylation des composés aromatiques non activés et désactivés. Notre but est de trouver des catalyseurs hétérogènes capables de catalyser cette réaction.
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Acylation of 1-(p-Acetoxyphenyl)-2,6-Dicarbethoxy-Cyclohexanedione-3,5
Since the substances synthesized and discussed in the present thesis are intermediates in the synthesis of the steroid group, it seems that a brief review of the steroids should furnish the necessary background. According to William H. Strain. |"Several classes of substances found in nature are …
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Enzymology and inhibition of ghrelin acylation by ghrelin O-acyltransferase
… and enable real-time monitoring of ghrelin acylation. A library screen of small molecules has revealed a novel class of small molecule inhibitors of human GOAT (hGOAT), which act by covalently modifying a functionally essential cysteine residue within the enzyme. Finally, mutagenesis studies …
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Investigating the mechanisms and outcomes of Sprouty-2 S-acylation
S-acylation is a reversible post-translational modification (PTM) that regulates proteins in several ways, including by modulating trafficking, stability and protein interactions. This PTM is mediated by twenty-three zinc finger DHHC (zDHHC) enzymes that display distinct activity and substrate …
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I The tandem chain extension-acylation reaction II Synthesis of papyracillic acid A: Application of the tandem homologation-acylation reaction III Synthesis of tetrahydrofuran-based peptidomimetics
<p>A zinc-mediated tandem chain extension-acylation reaction was successfully developed. This reaction was optimized with the use of beta-keto esters, amides, and imides as well as a variety of acylating agents. The tandem homologation-acylation reaction was successfully applied towards the total …
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Diastereoselective acylation of trans-2-substituted-cyclohexanols and glycosidase inhibition studies
… or diisopropylethylamine accelerates the acylation, and unexpectedly for some substituents (RX) may completely invert its diastereoselectivity. These observations have been rationalized in terms of a stereoselective intramolecular assistance by the RX group to the acylation of the …
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Structural and Functional Insights into Ghrelin Acylation by Ghrelin O-Acyltransferase
… and mechanism for GOAT catalyzed ghrelin acylation are presently undetermined. Purification of an active form of GOAT has been challenging, impeding structural studies of this integral membrane protein. To improve on these challenges, we have synergistically combined computational modeling …
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A kinetic study of the mechanism of o-acylation in pyridine
Dissertation (Ph.D.)--University of Kansas, Chemistry, 1953.
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Friedel-crafts acylation reactions using heterogeneous catalysts stimulated by microwave radiation
… sites. When the catalytic activities for the acylation of toluene and anisole were studied there was found to be a correlation between the Brønsted acidity and the catalytic activity. The reactivity of the catalysts is dependant upon both the concentration and the chain length of the …
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Lysophosphatidylcholine acyltransferase-2 (LPCAT-2) & protein S-acylation in macrophage innate immunity
… has been reported that LPCAT1 can catalyse the acylation of histone proteins. The addition of lipid groups to a protein can impact membrane-protein association, protein structure and protein stability ultimately affecting a proteins function. This gave rise to the main research question explored …
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Develoment and Application of Chemical Strategies to Study Protein Fatty-Acylation in Eukaryotes
… incorporated into proteins by endogenous fattyacylation machinery via native linkages at specific amino acid residues. In addition, shorter and longer chain fatty acids label myristoylated and palmitoylated proteins respectively. Since myristoylation is co-translational and constitutive, I …
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Potential prebiotic roles of (amino-)acylation in the synthesis and function of RNA
… for their non-enzymatic replication. Aminoacylation of RNA is an important process in modern biology but the intermediacy of aminoacyl-adenylates is considered to be prebiotically implausible. A potentially prebiotic aminoacylation of nucleoside-3'-phosphates, selective for the 2'-hydroxyl, …
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Biochemical characterization of the first step in ether lipid biosynthesis: acylation of dihydroxyacetone phosphate
… step in glycerolipid biosynthesis which involves acylation of glycerol-3-phosphate to lysophosphatidic acid. GPATs 1 and 2 localize to the mitochondria while GPATs 3 and 4 localize to the ER. This redundancy is poorly understood. A fifth acyltransferase, DHAPAT, known to metabolize …
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