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Showing 1 to 20 of 47 for “"Acute respiratory distress syndrome"”.
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Endotype Discovery in Acute Respiratory Distress Syndrome
Endotype Discovery in Acute Respiratory Distress Syndrome Dr Romit Samanta Acute respiratory distress syndrome (ARDS) affects 10% of critical care patients and is characterised by acute refractory hypoxaemia and bilateral pulmonary infiltrates on thoracic imaging. Mortality from severe ARDS is …
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Identification of novel coding single nucleotide polymorphisms associated with acute respiratory distress syndrome
… variants in complex genetic conditions such as acute respiratory distress syndrome (ARDS). To identify disease-causing variants in ARDS patients, whole-exome sequencing was performed on 96 patient DNA samples from the National Heart, Lung and Blood Institute's ARDS Network (ARDSnet). By …
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The effects of mechanical ventilation on the development of Acute Respiratory Distress Syndrome
Acute Respiratory Distress Syndrome (ARDS) is a severe lung illness characterized by inflammation and fluid accumulation in the respiratory system. Historically, ARDS and other forms of respiratory failure have been treated using mechanical ventilation to help maintain gas exchange in the lungs. …
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The role of inflammasomes in a murine model of acute respiratory distress syndrome (ARDS)
Acute respiratory distress syndrome is rapid pulmonary inflammation that can cause organ failure which is commonly caused by sepsis, severe pneumonia and trauma. ARDS has become one of the top research priorities since the SARS-CoV-2 outbreak in 2020. From injury to damaged tissue repair, cell …
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Human mesenchymal stromal cell regulation of pulmonary macrophage populations in the Acute Respiratory Distress Syndrome
The Acute Respiratory Distress Syndrome (ARDS) is a devastating clinical disorder characterised by excessive inflammation in the alveolar compartment resulting in oedema of the airspaces due to loss of integrity in the alveolar epithelial-endothelial barrier. ARDS is associated with high mortality …
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Incidence and Pathogenesis of Acute Lung Injury and the Acute Respiratory Distress Syndrome in Humans
Acute lung injury (ALI) and it’s more severe form, acute respiratory distress syndrome (ARDS), are conditions characterised by neutrophilic pulmonary inflammation, refractory hypoxaemia and diffuse alveolar damage. This work reports on the first UK based prospective study of the incidence and …
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Effects of hypercapnic acidosis on the primary cells relevant to acute respiratory distress syndrome pathophysiology and the therapeutic potential of Mesenchymal Stem Cells
Acute Respiratory Distress Syndrome (ARDS) is an inflammatory disorder in which the integrity of the alveolar epithelial-capillary endothelial barrier breaks down, facilitating the accumulation of a protein-rich oedema fluid within the alveoli. Despite years of clinical trials, no effective …
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Outcomes of patients with COVID-19 Acute Respiratory Distress Syndrome requiring Invasive Mechanical Ventilation admitted to an Intensive Care Unit in South Africa
Background Up to 30% of patients with COVID-19 pneumonia may require ICU admission or mechanical ventilation [Guan et al., 2020; Huang et al., 2020]. Data from low- and middle-income countries for COVID-19 ARDS are limited. Groote Schuur Hospital in Cape Town, South Africa expanded its ICU service …
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Der Sauerstoffverbrauch der Lunge (VO2pulm) bei Patienten mit Acute Lung Injury (ALI) und Acute Respiratory Distress Syndrome (ARDS) unter mechanischer Beatmung und PEEP-Variation, gemessen als VO2-Differenz zwischen indirekter Kalorimetrie und Berechnung über das inverse Fick´ sche Prinzip
Bei Patienten mit einem akuten Lungenversagen (ALI oder ARDS) ist der Sauerstoffverbrauch der Lunge (VO2pulm) durch pathophysiologische Prozesse insbesondere die Ausbildung von Atelektasen stark beeinträchtigt. Aufgrund der Annahme, dass eine Steigerung der Anzahl ventilierter Lungenareale zu einer …
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A Patient-Specific Multiscale Model of Mechanical Ventilation of COVID-19-afflicted Lungs
Coronavirus disease-2019 (COVID-19) is a respiratory disease that caused a worldwide pandemic and, in some cases, manifests as an acute respiratory distress syndrome. Severe cases of COVID-19 are often treated with mechanical ventilation, which has a high risk of causing ventilator-induced lung …
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Inhibition of Margination and Diapedesis of Neutrophils by Protein Synthesis Blockade
Acute Respiratory Distress Syndrome (ARDS), an age-old clinical problem facing the Emergency Department and Intensive Care Units of all health systems, is a common debilitating lung condition consequent upon severe systemic inflammation. Although several studies have gone into understanding the …
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The Development of Pulmonary Contusion Finite Element Model Metrics from Real World Simulations
… this injury can result in long term diminished respiratory function and an increased risk of complications. If 20% of the lung volume is injured, the patient has a significantly higher risk of developing Acute Respiratory Distress Syndrome (ARDS). Therefore, volumetric measurement of pulmonary …
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Integrin-independent activation of Tie2 using the de novo designed protein H8mb
… receptor internalization. In a mouse model of Acute Respiratory Distress Syndrome (ARDS), H8mb markedly improved survival. These findings show that designed receptor binding enables dissection of co-receptor control of signaling dynamics, potentially enabling the development of more selective …
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Ošetřovatelská péče o pacientku na extrakorporální membránové oxygenaci
… words: shock, septic shock, cardiogenic shock, acute respiratory distress syndrome, cardiomyopathy, extracorporeal membrane oxygenation, acute renal failure
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Targeting Endothelial Pathological Calcium Signaling Accelerates Resolution of SARS-CoV-2-Induced ARDS
Acute respiratory distress syndrome (ARDS) is a life-threatening condition characterized by diffuse alveolar damage, pulmonary edema, and severe hypoxemia, with limited therapeutic options. Increasing evidence identifies endothelial dysfunction and vascular barrier disruption as central drivers of …
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A review of the use of inhaled nitric oxide in the PICU at Red Cross Children's Hospital, 2011-2015: A retrospective cohort study
… as rescue therapy for refractory hypoxaemia in acute respiratory distress syndrome (ARDS) and pulmonary hypertension (PHT) following cardiac surgery. Objectives: To describe the response to treatment with iNO. Secondary observations were deaths, comorbidities of the patients treated, lengths of …
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PERINATAL CELLS AS A TREATMENT FOR INFLAMMATORY LUNG DISEASES
… obstructive pulmonary disease (COPD), asthma and acute respiratory distress syndrome (ARDS). Often, patients with inflammatory lung disease exhibit increased immune cell counts in their lungs such as neutrophils, macrophages and T cells accompanied by elevated levels of pro-inflammatory cytokines …
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Ketogenic Diet is Protective During Endotoxin-Induced Lung Injury
<p>Acute respiratory distress syndrome (ARDS) is a lung condition caused by uncontrolled lung inflammation with excessive immune cell infiltration, which eventually leads to severe pulmonary edema and poor oxygenation. ARDS affects hundreds of thousands of people a year, particularly those …
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Development of a superabsorber based haemofiltration technology for use in paediatric cardiac surgery
… severe cases, result in systemic immune responsesyndrome, acute respiratory distress syndrome, and organ failure.Modified Ultrafiltration (MUF) involves pumping blood through a haemofilter post-bypass toremove excess plasma, and has been shown to successfully moderate haemodilution and …
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