Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 34 for “"Acute phase response"”.
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The effect of a dietary phase 2 protein inducer on inflammatory parameters in blood and liver of spontaneously hypertensive stroke prone rats
… of oxidative stress is the inflammatory acute phase protein response. Oxidative stress and its accompanied inflammation can be reduced via phase 2 enzyme induction. Broccoli sprouts, a rich source of phase 2 enzyme inducers such as isothiocyanates, can be incorporated into the diet to …
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Immunoproteome of anti-TB drug associated DRESS in HIV TB co-infection
… disease states and drug rechallenge reactions. Acute phase proteins and immunoglobulin kappa variable chains dominate the serum proteome of acute DRESS in TB/HIV co-infected patients, with CRP having the highest fold change (q = 2.5) in acute versus early recovery samples. LRG and L-Selectin (q …
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Crebh, A Novel Liver Clock Keeper For Energy Metabolism
… transcription factor known to regulate hepatic acute-phase response and energy homeostasis under stress conditions. Here, we demonstrate that CREBH is regulated by the circadian clock and functions as a diurnal regulator of hepatic lipid and glucose metabolism. CREBH is required to maintain …
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Funktion der Protein-Tyrosin-Phosphatase SHP2 und des feedback-Inhibitors SOCS3 in der IL-6-Signaltransduktion
… the nucleus where they induce the expression of acute phase genes. Tyrosine 759 of gp130 was identified as an inhibitory motif for the Jak/STAT pathway. This tyrosine residue is a recruitment site for the protein tyroinse phosphatase SHP2 and for the STAT induced feedback inhibitor SOCS3. …
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Factors affecting severity of injury in allergic renal disease
… second group of experiments, the induction of an acute phase response in rabbits by the subcutaneous injection of a local irritant was studied. It was characterised by changes in C-reactive protein (CRP), the third component of complement (C3), fibrinogen and polymorphonuclear leucocytes (PMN' s), …
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Energy Balance, Immune System Function, and Susceptibility to Mastitis in Dairy Cows
… fuel source used by phagocytes during the immune response. Serum glucose concentrations were greater than those of cows experiencing postpartal NEB, which may at least partially explain the lack of effects observed in this study. Using large-scale studies and the most recent technological advances …
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Einfluss von metabolisch wirksamen Hormonen auf die IL-6-induzierte Signaltransduktion
… properties and is a main inducer of the acute-phase response. It is involved in the pathogenesis of inflammatory diseases like for example rheumatoid arthritis or multiple sclerosis. Glucocorticoids are steroid hormones that are widely used in the therapy of inflammatory diseases because …
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Peripheral Leukocytes and Intracerebral Hemorrhage
… it is unknown whether elevated WBCs represent an acute phase response or whether there is a pathophysiologic role of peripheral WBCs in ICH. Neutrophils and monocytes are predominant WBCs and peripheral neutrophil and monocyte infiltration have been found to contribute to secondary injury in …
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The Role Of Crebh In Hepatic Energy Regulation Under Metabolic Stress
… transcription factors, and cellular enzymes in response to nutritional, hormonal, and stress signals. Hepatocyte specific, cyclic AMP responsive element-binding protein (CREBH) is a transcription factor that is preferentially expressed in the liver and localized in the endoplasmic reticulum (ER) …
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Behavioral and Physiological Responses to Lipopolysaccharide in the Chicken
… of the physiologic, metabolic, and behavioral responses that accompany infection in mammals are important for maintaining homeostasis and promoting recovery. We have extended this concept to birds by demonstrating that lipopolysaccharide (LPS) injected intraperitoneally (i.p.) increases body …
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The effect of fasting on anti-inflammatory mediators, IL-1RA and IL-1R2, and their role in resistance to sickness behaviors in mice
… of interest. This research project confirms that acute dietary restriction (24 h water-only fast) is able to attenuate IL-1β-induced anorexia, in addition to other sickness behaviors at early stages of the acute phase response. We previously reported that fasting was able to reduce gene expression …
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The Role of NLPR3 Inflammasome in Response to Thermal Injury and Sepsis
Although the induction of acute-phase inflammation after burn injury is essential, if prolonged it can induce increased risk of infection and sepsis. The NLRP3 inflammasome has established itself as an integral mediator of the acute phase response, however there is a current lack of understanding …
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Functional Significance of Glycoprotein Clearance by the Asialoglycoprotein Receptor and the Mannose/GalNAc-4-SO4 Receptor
… Gal or GalNAc are cleared by the ASGR. Many are acute phase proteins and we propose that the ASGR helps regulate their relative concentrations in vivo and enhances their increase during the acute phase response. LH bears terminal GalNAc-4-SO4 and the half life of LH is increased in MR-/- mice …
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Role Of Crebh In Endotoxin Mediated Modulation Of Hepatic Metabolism
… that CREBH acts a key player in mounting an acute phase response against endotoxemia by modulating apolipoproteins. Endotoxin LPS shock in the body induces activation of the TLR4 signaling pathway in mouse liver. Upon triggering TLR4 signaling pathway, LPS stimulates cleavage and activation …
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Evaluation of serum protein-based arrival formula and serum protein (Gammulin) on performance, morbidity, and mortality of stressed (transport and cold) male dairy calves
… fed the serum protein product, indicators of acute-phase response were not affected; however, protein status of calves may have been improved by early serum protein supplementation.
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Role of the IKK complex during liver regeneration
… induced earlier in IKK2dhepa mice and the Acute Phase Response marker SAA showed an early and strong mRNA activation in KO compared to WT mice. In addition, PolyMorphoNuclear cells were recruited massively in IKK2dhepa liver 12h after hepatectomy. As a result of all these early events, …
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Comparative Plasma Proteomics in Muscle Atrophy Induced by Cancer Cachexia and Hindlimb Unloading
… were implicated in this analysis including the acute phase response signaling system and liver X receptor/retinoid X receptor (LXR/RXR) and farnesoid X receptor/retinoid X receptor (FXR/RXR) activation. Conclusion: Plasma proteomic profiles are altered in cancer cachexia and disuse-induced …
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A matched case control study of the nutritional status of newly diagnosed tuberculosis patients and tuberculosis free contacts in Delft, Western Cape
Background: Malnutrition is a risk factor for the development of pulmonary tuberculosis (TB) and may be responsible for the premature deaths of patients with active disease. An adequate nutritional status may therefore be protective in delaying the onset from latent infection to active disease. In …
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Effects of close-up dietary energy strategy and prepartal dietary monensin on hepatic mRNA expression of enzymes involved in glucose and lipid metabolism in transition cows
… (APOA1, APOB, FADS2, SCD, HMGCR), inflammation, acute phase response, and detoxification/oxidative stress genes (TNF, IL6, HP, GSTM1), growth hormone/IGF-1 axis genes (GHR, IGF1) and transcription factors (FOXA2, HNF4A, NR4A1, SREBPF2). In cows fed the CON diet, serum NEFA concentrations were …
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Analytical validation and evaluation of the effects of intramuscular injections on acute phase proteins in horses
Acute phase protein (APP) measurement can be used to characterize and detect inflammation, as well as monitor response to therapy. Intramuscular (IM) injections often result in local swelling and inflammation, which may lead to increased plasma concentrations of APP. The first objective of this …
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