Global ETD Search
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Showing 1 to 20 of 38 for “"Acute pancreatitis"”.
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Signaling and Adhesive Mechanisms in Acute Pancreatitis
Acute pancreatitis (AP) is an inflammatory disease with variable severity ranging from mild interstitial edematous to severe necrotizing disease. The overall mortality rate of AP is 8-9%. Specific treatment of AP is lacking which is partly related to an incomplete understanding of the basic …
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Acute pancreatitis - severity classification, complications and outcome
Acute pancreatitis, with an annual incidence of approximately 35 per 100 000 inhabitants in Sweden, is in most cases mild and self-limiting. Severe acute pancreatitis, affecting 10-15% of the cases is, however, associated with severe complications and even death. The optimal management of acute …
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Protease Activation and Inflammation in Acute Pancreatitis
Approximately 10—20 % of patients with acute pancreatitis (AP) develop a severe disease with high mortality and morbidity. Activation of pancreatic proteases, the inflammatory response and impaired pancreatic circulation are pathophysiological events that are important in order for the disease to …
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Isoprenylation and NET formation in acute pancreatitis
Acute Pancreatitis (AP) is an inflammation disease that characterized by activation of protease and the innate immune system, leading to infiltration of neutrophils and tissue damage in the pancreas. The aim of this thesis was to determine the role of isoprenylation (farnesyltransferase and …
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Prevention of Acute Pancreatitis by Broccoli Components
Acute pancreatitis is a common and refractory inflammatory disease affecting pancreatic acinar cells. Annually 300,000 patients are hospitalized. Attempts to halt the progression of the disease with anti-inflammatory drugs once pancreatitis has developed have been inconsistent. One promising area …
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Acute Pancreatitis. Studies on smoking and protease activation.
… to be a crucial event in the early phase of acute pancreatitis but the cause of this activation is not known. Most cases of acute pancreatitis can be attributed to either gallstone disease or alcohol abuse. However, little is known about other risk factors. The aim of this thesis is to …
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Emerging concepts in the pathophysiology of acute pancreatitis
There is no specific treatment for acute pancreatitis (AP) reflecting an incomplete understanding of the critical pathophysiological factors that determine severity, drive multiple organ dysfunction (MODS) and cause the high mortality. New treatment paradigms are needed, and this thesis explores …
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Acute pancreatitis, from local defense to remote organ injury
Acute pancreatitis (AP) is an inflammatory disease of the pancreas. Acute abdominal pain is the most common symptom. Pancreatic injury is mild in 80% of patients, who recover without complications. The remaining patients have a severe disease with local and systemic complications such as acute lung …
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Altered Morphology And Composition Of Zymogen Granules In Acute Pancreatitis
… Granules (ZG), and activated extracellularly. In acute pancreatitis however, the digestive enzymes are prematurely activated within the cell, resulting in autodigestion of the tissue. Pancreatitis is a gastrointestinal disorder in which there are over 200,000 hospitalizations per year with a 5% …
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Characterisation Of Cytokine Gene Polymorphisms In Patients With Acute Pancreatitis
Background and Aims Acute Pancreatitis is an inflammatory disorder of varied aetiology and outcome. Tumour necrosis factor (TNF) and interleukin-10 are important mediators of disease pathogenesis. To investigate if the TNF and IL-10 gene loci influence susceptibility to and severity of acute …
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INITIATION OF EXPERIMENTAL ACUTE PANCREATITIS AND MODULATION OF INFLAMMATORY RESPONSE
… response, which if excessive can cause acute pancreatitis (AP). Infusion of HS in the pancreatic duct in rats results in an inflammatory response without cellular damage, in similarity with lipopolysaccharide (LPS) infusion. The response differs though between the HS- and LPS-infusion …
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Optimising the management of new-onset prediabetes/diabetes after acute pancreatitis
Background: New-onset prediabetes/diabetes after acute pancreatitis (NOPAP/NODAP) is recognised as a clinically distinct entity, yet individuals with NOPAP/NODAP are often misclassified as type 2 diabetes mellitus. Further, given its until recent nosologic dereliction, there is not only a lack of …
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A Study Of The Role Of Cytokines In Acute Pancreatitis In Man
Introduction: Acute pancreatitis is an inflammatory disease with a diverse aetiology and variableclinical course. The IL-l gene cluster has been implicated in this disease.Aims: The aims of the study were to investigate polymorphisms of the genes encoded within the IL-lgene cluster in patients with …
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Crosstalk between Inflammation and Coagulation in Acute Pancreatitis - Experimental and Clinical Studies.
… between inflammation and coagulation in acute pancreatitis (AP) has been investigated. The results from the first paper, where active site inactivated FVII (FVIIai) is given as pre-treatment in a rat model of severe AP, show a decreased inflammatory response in the FVIIai pre-treated …
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Preclinical Development of a Pharmacologic Agent for the Treatment of Recurrent Acute Pancreatitis
Chronic pancreatitis (CP) is an irreversible disease process defined by acinar cell necrosis, inflammation and fibrosis. With disease progression, patients develop pancreatic insufficiency secondary to the destruction of functional pancreatic tissue and its replacement with scarring. Patients with …
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Role of neurogenic inflammation in the pathogenesis of acute pancreatitis and associated lung injury
… in the neurogenic inflammation (NI) during acute pancreatitis (AP). The effects of neurokinin receptor antagonists on caerulein-induced AP in mouse were investigated. NK1R antagonist, CP96,345, significantly reduced the severity of AP and associated lung injury. Present study demonstrated …
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The value of inflammation markers in early acute pancreatitis course prediction: the results of prospective multicenter cohort study /
The mortality rate of patients with severe acute pancreatitis (SAP) can reach up to 30%. Early and appropriate treatment will progress in reducing rates of SAP complications. The main problem remains, that neither prognostic scores nor single predictors can’t accurately predict the disease course …
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Chemokines as therapeutic targets in systematic inflammatory response syndrome
… mediators in the development of both acute pancreatitis and sepsis. The present study has shown that blockage of CCR1 by a small molecule CCR1 antagonist has protective effect against acute lung injury in animal models of acute pancreatitis and sepsis. Depletion of mast cells by …
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ΠΕΙΡΑΜΑΤΙΚΗ ΟΞΕΙΑ ΠΑΓΚΡΕΑΤΙΤΙΔΑ ΜΕ ΤΗ ΜΕΘΟΔΟ ΤΗΣ ΚΛΕΙΣΤΗΣ ΔΩΔΕΚΑΔΑΚΤΥΛΙΚΗΣ ΕΛΙΚΑΣ
… OF BILE AND GASTRIC JUICE IN THE PATHOGENESIS OF ACUTE PANCREATITIS INDUCED BY THE CLOSED DUODENAL LOOP TECHNIQUE. THE EXPERIMENTS WERE PERFORMED IN TWO STEPS IN ORDER TO AVOID OBSTRUCTIVE JAUDICE, AND MINIMIZE ISCHAEMIA AND TRAUMA. AFTER LIGATION ABOVE (WHEN IT NEEDED) AND BELOW THE MAJOR AND …
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CHARACTERIZATION OF IMMUNE RESPONSE IN EXPERIMENTAL MOUSE MODELS
… of inflammation in a murine caerulein-induced acute pancreatitis model. Study III – Comparison between two methods of digital image analysis (hot-spot fields vs whole-slide) for the assessment of immune cell infiltrations in a murine caerulein-induced acute pancreatitis model. Study IV – Tumor …
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