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Showing 1 to 20 of 105 for “"Acute lymphoblastic leukemia"”.
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Chromatin Architecture Aberrations Contribute and Acute Lymphoblastic Leukemia Relapse
… and epigenetic changes that underlie B-cell acute lymphoblastic leukemia relapse. I found recurrent loss of DNA methylation in patient-matched relapse samples that indicate a more stem-like chromatin state. Together, my work investigates the relationship between multiple components of the …
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Developing Targeted Therapies for T-cell Acute Lymphoblastic Leukemia
<strong>Introduction</strong> Acute lymphoblastic leukemia (ALL) is the most common cancer in children, and risk-adapted chemotherapies have dramatically improved the outcomes of this disease. Compared to B-cell ALL, T-cell ALL (T-ALL) is more aggressive and has worse outcomes from chemotherapy. …
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Genetic Characterization of Pediatric T-cell Acute Lymphoblastic Leukemia
… to characterize genetically pediatric T-cell acute lymphoblastic leukemia (T-ALL). Articles I and II focus on molecular characterization of translocations involving T-cell receptor (TCR) loci. These types of aberration are characteristic for T-ALL and have previously proved pivotal in the …
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Genomic characterization of ETV6/RUNX1-positive acute lymphoblastic leukemia
… fusion gene, present in 25% of childhood acute lymphoblastic leukemia. This fusion gene is important for leukemia development but is not sufficient for leukemia to arise. Hence, the additional genetic changes present in leukemic ETV6/RUNX1-positive cells give important clues regarding the …
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Motor functioning in childhood survivors of acute lymphoblastic leukemia
<p>Acute lymphoblastic leukemia (ALL) can cause a multitude of neuropsychological sequelae, or late effects, in children following intensive medical treatment. Late effect research has focused primarily on non-motor related sequelae; however, recent studies have begun to highlight evident …
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Dietary Intake among Children with Acute Lymphoblastic Leukemia (ALL)
Children with acute lymphoblastic leukemia (ALL) are at elevated risk for nutrition-related morbidities both during and after therapy. The degree to which dietary intake fluctuates during cancer therapy and possibly contributes to the development of nutrition-related morbidities is unknown. This …
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Role of ETV5 Mutations in B Cell Acute Lymphoblastic Leukemia
B cell acute lymphoblastic leukemia (B-ALL) develops through the acquisition of driver mutations that impair cell differentiation and promote proliferation. In human B-ALL, mutations in E26 transformation-specific (ETS) transcription factors are commonly reported. Our laboratory studies a mouse …
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Characterization of Transcription Factor-Coactivator Complexes in Acute Lymphoblastic Leukemia
Acute lymphoblastic leukemia (ALL) is a cancerous hematological disorder originating in B-lymphoid progenitor cells. In 5% of ALL cases, the oncogenic transcription factor E2A-PBX1 is expressed as a result of the chromosomal translocation 1;19. E2A-PBX1 contains the activation domains of E2A and …
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Hierarchical neuropsychological functioning in pediatric survivors of acute lymphoblastic leukemia.
Acute lymphocytic leukemia (ALL) is one of the most common types of pediatric cancers. Improvements in treatment within the last 20 years have resulted in reduced mortality and a greater focus upon quality of life. Several researchers have documented neuropsychological impairments in children …
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Genetic Mechanisms of Transcriptional Regulation in Childhood Acute Lymphoblastic Leukemia
… understanding of the genetic basis of childhood acute lymphoblastic leukemia (ALL). Recent genome-wide association studies (GWAS) have identified germline genetic variations of ARID5B and, more recently, IGF2BP1 that are associated with susceptibility to ALL. Genome-wide sequencing studies also …
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Adverse Effects of Asparaginase in Pediatric Patients with Acute Lymphoblastic Leukemia
<p>Acute lymphoblastic leukemia (ALL) is the most common type of childhood cancer. Asparaginase is a critical treatment component for ALL. However, its use is complicated by adverse effects, such as hypersensitivity, osteonecrosis and pancreatitis.</p> <p>Hypersensitivity to asparaginase typically …
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Hand-Wrist Bone Age in Children Treated for Acute Lymphoblastic Leukemia
<p>Acute Lymphoblastic Leukemia (ALL) is the most common malignancy of childhood, constituting 31 percent of all childhood malignancies. Treatment strategies to target ALL include chemotherapeutic agents, irradiation of the neck and/or spine, and bone marrow transplantation. The aggressive nature …
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Pax5 Haploinsufficiency Cooperates with BCR-ABL1 to Induce Acute Lymphoblastic Leukemia
<p>Acute lymphoblastic leukemia (ALL) is the commonest pediatric malignancy and comprises several distinct subtypes each with its own unique pathogenesis, clinical behavior, and response to therapy. Chromosomal aberrations are a hallmark of ALL but alone fail to induce leukemia. Pediatric ALLs can …
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Characterizing the Role of TLX1 in T-cell Acute Lymphoblastic Leukemia
T-cell Acute Lymphoblastic Leukemias (T-ALLs) are aggressive hematological tumors caused by the aberrant expression of a subset of transcription factors (TFs) in T-cell progenitors1–3 . The identification of diverse sets of secondary mutations in T-ALL tumors suggests a complex process of clonal …
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Genetic and epigenetic characterization of pediatric high hyperdiploid acute lymphoblastic leukemia
… characteristics of pediatric high hyperdiploid acute lymphoblastic leukemia (HeH ALL), the most common type of childhood malignancy. The three original articles presented in this thesis have addressed three major questions regarding HeH ALL: what are the genetic characteristics of the most …
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Molecular Genetic Characterization of Acute Lymphoblastic Leukemia with a Poor Prognosis
Acute lymphoblastic leukemia (ALL) affects individuals at all ages, with peak incidences in children <4 years and adults >50 years. ALL is broadly categorized into B-cell precursor (BCP) and T-cell ALL with specific clinical features associated with outcome. In contrast to pediatric ALL, which has …
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Notch Signaling Inhibited By Ikaros1 In Human T-Cell Acute Lymphoblastic Leukemia
… The majority of patients with T-cell acute lymphoblastic leukemia (TALL) have activating Notch mutations. Similarly, Notch activation is present in more than 75% of murine T-ALL models. In murine T-ALL, loss of Ikaros, a zinc finger transcriptional regulator, leads to disrupted …
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Neurocognitive outcomes in children experiencing seizures during treatment for acute lymphoblastic leukemia
… who experience seizures while treated for acute lymphoblastic leukemia. This study examined prevalence of on-protocol seizures, seizure risk factors, and neurocognitive change in children with therapy-related seizures in comparison to the normative sample and a matched cohort of children …
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BiTEs and CAR-Ts : immunotherapy in childhood B-cell acute lymphoblastic leukemia
B-cell acute lymphoblastic leukemia is the most common pediatric cancer, responsible for the most cancer-related deaths in children. Advances in chemotherapy over the past half-century have steadily increased the remission and survival of children with B-cell acute lymphoblastic leukemia to nearly …
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