Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 14 of 14 for “"Acute liver failure"”.
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A retrospective review of acute liver failure in children admitted at Red Cross War Memorial Children's Hospital
Acute liver failure (ALF) describes a clinical syndrome resulting from severe liver damage and extensive loss of functional parenchymal liver mass triggered by various factors. Early recognition and initiation of specific therapy may improve outcomes and reduce the need for liver transplantation, a …
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Use of methionine sulfoximine to dissect the role of glutamine synthetase and glutamine in progression of acute liver failure
… of an immune response. </p> <p>To induce acute liver failure (ALF) in mice, animals were given intraperitoneal injections of E. coli lipopolysaccharides (LPS) and sugar D-galactosamine (D-GalN). When these animals were pretreated with MSO, 80% of the animals were completely rescued from …
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Manipulating macrophages to enhance liver regeneration
Acute liver failure confers a high risk of death, with liver transplantation offering the only effective therapy for life-threatening cases. Hepatic macrophages are crucial for innate immune integrity and effective hepatocyte proliferation. The macrophage may therefore present a novel therapeutic …
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Paracetamol intoxications: A population-based study in Iceland
… Paracetamol is the most common cause of acute liver failure (ALF) in the US and many countries in Europe. Most data on paracetamol toxicity originate from liver transplant centres and tertiary referral institutions. The proportion of patients with paracetamol overdose who develop liver …
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Cellular and molecular immunotherapeutics derived from the bone marrow stroma
… loss of potency and stored for point-of-care delivery; and (4) human trials of MSCs thus far have shown no adverse reactions to allogeneic versus autologous MSC transplants suggesting that therapy can cross histocompatibility barriers. This thesis describes the development of new modalities and …
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A systems toxicology framework for improving the identification of paracetamol overdose
… (APAP) overdose is the leading cause of acute liver failure and a concerning global health issue. However, the current clinical treatment framework is heavily criticized for its sub-optimality. Within this thesis, a systems toxicology approach is taken in an attempt to provide further …
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Bio-artificial liver support system : an evaluation of models used in demonstrating or improving metabolic and clinical efficacy
Acute liver failure (ALF) is a rare but devastating clinical syndrome with multiple causes and a variable course. The mortality rate is high. Orthotopic liver transplantation is the only therapy of proven survival benefit but the limited supply of donor organs, the rapidity of progression and the …
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N-Acetylcysteine for non-paracetamol drug-induced liver injury: A systemic review
… are limited therapeutic options for drug-induced liver injury (DILI). N-acetylcysteine (NAC ) is known to be of benefit in management of DILI due to paracetamol overdose and may also be useful in the management of non-paracetamol DILI. Our objective was to systematically review evidence for the …
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NON-INVASIVE MONITORING OF INTRACRANIAL PRESSURE USING TRANSCRANIAL DOPPLER ULTRASONOGRAPHY
… TBI and brain midline shift, patients with acute liver failure during liver transplant surgery, and patients during non-neurosurgical surgery in the beach chair position. III) The description and assessment of a novel methodology for non-invasive assessment of cerebral perfusion pressure …
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Human Liver Organoids as models for investigating drug-induced liver injury
The liver is the primary organ involved in drug detoxification, hence being highly exposed to the risk of drug induced liver injury (DILI). DILI is the main cause for acute liver failure in western countries and post-marketing withdrawal of drugs. This is highly due to the poor identification of …
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The Role of Serine Protease Inhibitors in Regulating Hepatotoxicity During Viral Infection
… and HCV, are not directly cytopathic; instead liver injury is due to a vigorous immune response. Cytotoxic T lymphocytes (CTL) and natural killer (NK) cells kill virally infected and malignant cells by two major pathways, the perforin/granzyme pathway and the Fas and/or TNF death receptor …
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ROLE OF DNA DAMAGE RESPONSE IN LIVER REGENERATION AFTER APAP OVERDOSE INDUCED ALF
… (APAP) overdose is a leading cause of acute liver failure (ALF) with limited treatment options. The mechanisms of APAP-induced liver injury include formation of a reactive metabolite N-acetyl-p-quinoneimine (NAPQI) and it’s covalent binding to protein, oxidative stress, mitochondrial …
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Hepatic stellate cell heterogeneity and function during the hepatic regenerative response
… (APAP) poisoning is the commonest cause of acute liver failure (ALF) in the Western world1 and results in centrilobular hepatic necrosis. In non-severe cases the liver regenerates to normal microarchitecture and function. However, in severe APAP-induced ALF, transplantation remains the only …
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High-throughput approaches to sourcing of human hepatocytes for cell-based therapies
Chronic liver disease affects more than 500 million people worldwide. The only therapy shown to directly prevent mortality is organ transplantation. However, there is growing discrepancy between supply and demand of transplant-grade organs and transplant recipients are subject to a lifetime of …