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Showing 1 to 20 of 24 for “"Acute leukemia"”.

  1. Investigating the Role of ZNF384 Rearrangements in Acute Leukemia

    Dickerson, Kirsten2022

    … lesion in 5% of pediatric and adult B-cell acute lymphoblastic leukemia and tumors are characterized by aberrant myeloid marker expression. Additionally, ZNF384 rearrangements are the defining lesion in nearly half of pediatric B/myeloid mixed phenotype acute leukemia. These fusions …

    tenn-hsc Repository record

  2. CT Evaluation of Acut Abdominal Painin Patientswit Acute Leukemia

    한, 태선2014

    … abdominal symptoms can occur in patients with leukemia such as neutropenic enterocolitis, leukemic infiltration of GI tract, and infectious enterocolitis. However, many imaging finding of such diseases can have overlapping findings. The purpose of this study was to evaluate clinical data and CT …

    ajou Repository record

  3. Targeting Protein Degradation to Uncover Novel Oncoprotein Drivers of Acute Leukemia

    Keramatnia, Fatemeh2024

    <p>Acute Lymphoblastic Leukemia (ALL), the most common childhood cancer and the second most common acute leukemia in adults, arises from clonal expansion of undifferentiated lymphoid precursor cells in bone marrow. Despite the extensive knowledge on its cytogenetic and molecular biology, ALL …

    tenn-hsc Repository record

  4. The Heme-Regulated Inhibitor Pathway Modulates Susceptibility of Poor Prognosis B-Lineage Acute Leukemia to BH3-Mimetics

    Smith, Kaitlyn Hill2021

    … of DHA and BH3-mimetics compared to wild-type leukemia. Furthermore, BTdCPU, a small-molecule activator of HRI, similarly triggers MCL-1 repression and synergizes with BH3-mimetics in mouse and human leukemia including both Ph+ and Ph-like B-ALL. Lastly, combinatorial treatment of leukemia …

    tenn-hsc Repository record

  5. CHILDHOOD ACUTE LEUKEMIAS IN SINGAPORE

    SUN LI1998

    Acute leukemia is the major form of malignancy in children. Acute leukemia includes a heterogeneous group of malignant diseases derived from transformed haematopoietic progenitors at various stages of differentiation. Research in acute leukemia involves a very broad spectrum of topics, which can be …

    nus Repository record

  6. The significance of aberrant phenotypes and multidrug resistance for evaluation of the dynamics of minimal residual disease in acute leukemia patients /

    Janeliūnienė, Miglė,Institutional Repository of Vilnius University2012

    With application of modern treatment most acute leukemia patients achieve complete clinical and morphological remission, however due to the persistence of submicroscopic level of leukemic cells some patients eventually relapse. The purpose of this study was to verify the hypothesis that the …

    vilnius Repository record

  7. Sergančiųjų ūmine leukemija aberantinių fenotipų ir dauginio atsparumo vaistams nustatymas ir svarba vertinant minimalios liekamosios ligos dinamiką /

    Janeliūnienė, Miglė,Institutional Repository of Vilnius University2012

    With application of modern treatment, most acute leukemia patients achieve complete clinical and morphological remission, however some of them eventually relapse due to the persistence of leukemic cells. We tried to verify the hypothesis that the detection of aberrant phenotypes by flow cytometry …

    vilnius Repository record

  8. Application of Multiplex Reverse-Transcriptase Polymerase Chain Reaction for Identification of Leukemia Associated Gene Abnormalities

    정, 연무2011

    PUOPOSE: The best prognostic predictor for acute leukemia is known to be the finding of genetic abnormalities of leukemic cells. Methods for detecting the genetic abnormalities include chromosomal studies for karyotyping, FISH(Fluorescence in situ hybridization) and RT-PCR. However, each methods …

    ajou Repository record

  9. Interactions of Anticancer Drugs With DNA Studied by High-Resolution NMR Spectroscopy

    Lian, ChenyangUniversity of Illinois at Urbana-Champaign2015

    … daunorubicin has been widely used to treat acute leukemia clinically. The newly designed bisanthracycline bisintercalator WP631 has shown promising results against the anthracycline resistance that is due to the transport proteins, e.g., P-glycoprotein. The 3D structures of 1:1 …

    uiuc Repository record

  10. Flow cytometry in the diagnosis and prognosis of canine lymphoma and leukemia

    Wiseman, Michael, author, Avery, Paul R., advisor, Morley, Paul S., committee member, Olver, Christine S., committee memberColorado State University. Libraries2010

    … and clinical features of canine CD34+ acute leukemias. Flow cytometry data, CBC and blood film evaluation from 11 dogs with CD34+ acute leukemia were compared to 11 dogs with CD34- acute leukemia in order to identify qualitative differences in terms of cellular morphology, degree of …

    colostate Repository record

  11. Developing novel SNAP tag-based antibody fusion proteins directionally conjugated to fluorophores for immunophenotyping of acute myeloid leukemia

    Bvudzijena, Tatenda LovemoreInstitute of Infectious Disease and Molecular Medicine2024

    Acute Leukemia comprising of acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL), represents a clonal malignant transformation of hematopoietic cells originating in the bone marrow or lymphoid organs. This is often associated with fundamental genetic abnormalities, and these …

    cape-town Repository record

  12. A Novel NGS Assay to Detect Any KMT2A Fusion Transcript at Low Levels

    Issa, Ghayas, <p>0000-0002-4339-8683</p>2024

    … detection is associated with cancer relapse. Leukemias with rearrangement of the lysine methyltransferase 2 A gene (<em>KMT2Ar</em>) have an adverse prognosis with more than 80 possible fusion partner genes (FPG) identified. With the advent of effective targeted therapies for <em>KMT2Ar</em> …

    uthsc Repository record

  13. Modeling Renal Anomalies Associated with Li-Fraumeni Patients: A Novel Role for p53 in Kidney Development

    Davilavaladez, Alejandra, <p>https://orcid.org/0000-0002-8299-1383</p>2026

    … including osteosarcoma, soft tissue sarcoma, acute leukemia, and adrenal cortical tumors, as well as breast and brain cancer. Additionally, these patients have an increased risk of developing kidney, stomach, colon, pancreas, esophagus, lung, and gonadal germ cell cancers. Prior studies …

    uthsc Repository record

  14. Transcriptional and Translational Products of Avian Erythroblastosis and Avian Myeloblastosis Viruses

    Anderson, Steven Mathias

    … and translation products of two avian acute leukemia viruses, avian erythroblastosisvirus (AEV) and avian myeloblastosisvirus (AMV), were examined. AEV is defective in virus replication and requires the presence of a helper virus to produce infectious progeny. AEV-transformed …

    rockefeller Repository record

  15. The Wilms' tumor gene 1 (WT1) and leukemia -new insights and further complexity

    Svensson, EmelieDivision of Hematology and Transfusion Medicine, Department of Laboratory Medicine, Lund University2006

    … of WT1 and the presence of somatic mutations in acute leukemia indicate a role for WT1 in the pathogenesis of leukemia. The ojective of this thesis was to investigate the role of WT1 during human hematopoiesis and leukemia. To gain further insights in how wild type WT1 and mutant WT1 affect …

    lund Repository record

  16. Role of S6K1 in regulating self-renewal of hematopoietic stem cells and propagatoin of leukemia

    Ghosh, Joydeep2015

    … assessed the role of S6K1 in the propagation of acute myeloid leukemia (AML). The mixed-lineage leukemia (MLL) gene is required for the maintenance of adult HSCs. Translocations in MLL are detected in approximately 5-10% of adult acute leukemia patients and in approximately 70% of acute …

    iupui Repository record

  17. Benzene Related Hematological Disorders: Evidence for a Threshold in Animals and Humans

    McCluskey, JamesDigital Commons @ University of South Florida2008

    … that there were an unusually large number of acute leukemia cases in this cohort of workers. Since that time, multiple follow-up evaluations of the same cohort have attempted to refine the benzene exposure of these workers. Benzene has subsequently been classified as a human carcinogen by …

    usf Repository record

  18. Critical Functions Specified by the MLL CXXC Domain Determine Leukemogenic Capacity

    Birch, Noah Warren1970

    <p>TheMixed Lineage Leukemia(MLL) gene can participate in chromosomal translocations which generate a fusion protein leading to acute leukemia. A better understanding of how MLL fusion proteins contribute to leukemia is necessary in order to develop more effective treatments. In my dissertation …

    loyola-thes Repository record

  19. An integrative bioinformatics approach to characterize molecular landscapes and clinical outcomes in acute leukemias

    Wolgast, NadineChristian-Albrechts-Universität zu Kiel

    Acute leukemias are biologically and clinically heterogeneous hematologic malignancies. This dissertation examines this heterogeneity at three levels: population-based disease patterns, RNA-seq-based molecular classification, and developmental interpretation. First, nationwide German cancer …

    cau-kiel Repository record

  20. INSIGHTS ON THE CROSSTALK BETWEEN THE IMMUNE SYSTEMAND CANCER: IMMUNE CHECKPOINT MOLECULES AND LYMPHOIDPOPULATIONS ASSESSMENT IN CANINE ROUND CELL TUMORS

    UBIALI, ALESSANDRAUniversità degli Studi di Milano2026

    … expression and prognostic role of CD47 in canine leukemias, and (3) the characterization of lymphocyte populations in peripheral blood and sentinel lymph nodes (SLNs) of dogs with mast cell tumors (MCTs). Regarding PD-L1, the project evaluated the expression of the surface membrane protein …

    milano Repository record

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