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Showing 1 to 20 of 73 for “"Acute kidney injury"”.
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Vascular Mechanisms of Rhabdomyolysis-induced Acute Kidney Injury
… into circulation is the primary cause of kidney injury. Myoglobin causes direct kidney injury as well as severe renal vasoconstriction. An increase in renal vascular resistance (RVR) results in renal blood flow (RBF) and glomerular filtration rate (GFR) reduction, tubular injury, and acute …
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Role of the macrophage in acute kidney injury
Ischaemia/Reperfusion Injury (IRI) is the most common cause of acute kidney injury- a devastating clinical problem lacking any specific treatments to promote renal recovery. Macrophages (Mφ) are pleiotropic cells of the innate immune system, with roles spanning host defence, cytotoxicity, clearance …
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Rhabdomyolysis-induced Acute Kidney Injury in Sickle Cell Disease
… from the destruction of skeletal muscle fibers. Acute kidney injury (AKI), a major complication of rhabdomyolysis, contributes to long-term morbidity through the development of chronic kidney disease and cardiovascular disease. Both of these are leading causes of mortality in individuals with …
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Acute Kidney Injury in In-patient undergoing Enhanced CT
배경: 최근 의학기술의 발달에 따라 조영제에의 노출은 증가 추세이나 부작용을 줄이기 위한 저삼투질 비이온성 조영제의 보급으로 조영제에 의한 신손상의 증감에 대해 많은 보고가 있다. 본 연구에서는 조영제 사용 전산화 단층촬영을 시행한 입원환자에서 급성 신손상의 발생빈도와 시점에 대해 점검해보고자 하였다. 대상 및 방법: 2010년 3월 1일부터 7월 30일까지 5개월동안 아주대학교 병원에 입원하여 전산화 단층촬영을 시행받은 환자 128명을 대상으로 하였다. 의무기록과 조영제 투여 전후의 검사실 소견을 조사하였고 조영제에 의한 급성 …
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Paediatric acute kidney injury management in an African setting
Kidney disease is a growing public health concern, affecting adults but also children who face challenges of access in low-resource settings including Africa. We studied our own paediatric dialysis results, our fellows training in the field of acute kidney injury (AKI) and reviewed innovative …
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Biomarkers and Factors related to Risk of Acute Kidney Injury
<p><strong>Background: </strong>Acute kidney injury (AKI) is associated with increased mortality, morbidity, length of hospital stay, and in-hospital cost. Timely intervention is needed to prevent disease progression, but the delay in diagnostic process often results in delayed treatment. Recent …
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Ischemic Preconditioning and Hydrodynamic Delivery for the Prevention of Acute Kidney Injury
Acute Kidney Injury (AKI) is a prevalent and significant problem whose primary treatment is supportive care. Ischemic preconditioning is a strategy used to protect organs from ischemic injury via a prior injury. Ischemic preconditioning in the kidneys has been shown to confer protection onto …
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An analysis of the mechanisms of acute kidney injury and novel biomarkers
Acute Kidney Injury (AKI) is a prevalent systemic disorder that has an extremely high rate of mortality even after detection. Historically, the diagnosis and treatment of AKI was marred by the lack of universally accepted criteria defining AKI. Therefore, reports of incidence and mortality varied …
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Effect of renal replacement therapy on acute kidney injury in sepsis patients
… of sepsis is organ failure, notably in the kidneys, lungs, liver, and brain. In the case where the kidneys fail, renal replacement therapy (RRT) may be performed in order to sustain the functionality of the kidneys and overall ameliorate patients' outcomes. The goal of this work is to …
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Gravity assisted continuous flow peritoneal dialysis (CFPD) in children with acute kidney injury
… dialysis (PD) has long been a mainstay of acute kidney injury (AKI) management in children of all ages, and it remains the most commonly used modality in low-income regions, where continuous kidney replacement therapy (CKRT) is not widely available. Compared to extracorporeal therapies, PD …
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An audit of acute kidney injury : a prospective study of the epidemiology, management and outcome of patients with acute kidney injury, over a 12 month period at Groote Schuur Hospital, Cape Town, South Africa
Introduction: Acute kidney injury results from a rapid decline in kidney function. There are many potential causes, some of which are preventable. It carries the risks of mortality, progression to chronic kidney disease and worsening of pre-existing chronic kidney disease. There is a scarcity of …
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Identification of Early Diagnostic and Predictive Biomarkers of Cisplatin-Induced Acute Kidney Injury Using Metabolomics
… toxicity in cisplatin therapy, manifesting as acute kidney injury (AKI) in approximately one-third of patients receiving cisplatin. AKI is defined as an abrupt decline in kidney function and is associated with several short- and long-term adverse outcomes, including chronic kidney disease, …
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Role of Acute Kidney Injury Heterogeneity in Continuous Renal Replacement Therapy Initiation Timing and Outcomes
Pages i-88 are misnumbered as pages ii-89.
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Incidence, Characteristics, and Outcomes of Acute Kidney Injury Treated with Dialysis during Pregnancy and the Postpartum Period
Pregnancy-related acute kidney injury (AKI) may be associated with significant morbidity and mortality in young and often otherwise healthy women. We conducted a retrospective cohort study of all consecutive pregnancies between 1997 and 2011 in Ontario and describe the incidence, characteristics, …
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Patterns of acute kidney injury and functional outcome scores in pediatric patients hospitalized with acute respiratory failure
BackgroundAcute kidney injury (AKI) is diagnosed in up to 30% of children admitted to pediatric intensive care units (PICU) and is strongly associated with morbidity and mortality. In recent years, there has been an increased focus on patient-centered outcomes and quality of life among survivors of …
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Localized customized mortality prediction modeling for patients with acute kidney injury admitted to the intensive care unit
… hypothesis on patients admitted to the ICU with acute kidney injury (AKI), and evaluated variables from the first 72 hours of admission. Methods. The Multi-parameter Intelligent Monitoring for Intensive Care II (MIMIC II) is a database of patients admitted to the Beth Israel Deaconess Medical …
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Establishing a Murine Model of Malaria-Associated Acute Kidney Injury and Demonstrating the Contribution of Extrinsic Apoptosis to Tubular Necrosis
<p>Malaria-associated acute kidney injury (MAKI) is a form of severe malaria (SM), which is usually caused by Plasmodium falciparum infection. Until recently, the impact of this particular complication of SM was severely underestimated and research in this area has been neglected. There is in fact …
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