Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 43 for “"Acute infection"”.
-
Transcriptomic predictors of outcomes in acute infection
Suspected acute infection is a major cause of hospital attendance in the UK. Acute infectious diseases that progress to sepsis, defined as life-threatening organ dysfunction due to a dysregulated host response to infection, lead to high patient morbidity and mortality. Conditions that mimic acute …
-
Studies on babesiosis, with particular reference to chronic parasitaemias
The thesis describes observations carried out on infections caused by various Babesia spp. in mice, rats and cattle with particular reference to a study of parasitaemias after acute infection.
-
Bio-Behavioral Models for HIV Prevention
… given the critical interaction between acute infection and rate of movement. In the population of MSM in Southern California, I model post-diagnosis behavior change (PDBC). The objective in Chapter 3 is to quantify the population-level effects of individual-level PDBC. A second objective …
-
Characterizing 3D epigenomes in pathological conditions
… contexts: Trisomy 21 neural stem cells and cells acutely infected with SARS-CoV-2. For Trisomy 21 cells, I applied a cutting-edge, combinatorial indexing-based single-cell RNA sequencing approach to chart the developmental progression of trisomic brain organoids. This single-cell transcriptomic …
-
Sex-influenced histopathological changes and the immunity during Toxoplasma gondii infection
… female mice are more susceptible to T. gondii infection in comparison to male mice. The following studies were undertaken to enhance our understanding about the influence of sex in the immune response during T. gondii infection and the disease outcome in BALB/c mice. Early parasite replication …
-
Cardiac cycle timing intervals in acute COVID-19 and recovered COVID-19 with sustained symptoms
… to show that COVID-19 can result in both acute and sustained cardiac damage. Acute cardiac damage may be due to elevated inflammatory responses and can result in ischemia, which can lead to impairments in the cardiac cycle timing events. The purpose of this project was threefold: 1) to …
-
The impact of a single nucleotide polymorphism in fusA1 on biofilm formation and virulence in Pseudomonas aeruginosa
… fibrosis (CF) commonly encounter P. aeruginosa infections. P. aeruginosa infection can present itself as an acute infection, which is characterised by highly virulent, “free-swimming” bacteria, or as a chronic infection associated with the formation of surface-adhered bacterial communities known …
-
The role of erythropoietin in the pathophysiology of anemia associated with trypanosomiasis
… anemia associated with Trypanosoma congolense infection in cattle at the molecular and cellular levels. Bovine Epo cDNA from N’Dama cattle (Bos taurus) and Boran cattle (Bos indicus) was isolated by polymerase chain reaction (PCR) amplification and by screening of a bovine kidney cDNA library. …
-
The Development and Function of Memory Regulatory T Cells
… roles for TReg cells during pathogen infection, which will be the focus of this thesis.</p><p>Studies examining TReg cells during infection have largely focused on chronic infection models. These studies have shown that TReg cells can affect responses to pathogens in various ways that …
-
Mathematical Models of Underlying Dynamics in Acute and Chronic Immunology
… in these later immune responses. When comparing acute infections to chronic infections, there are also differences in the dynamics of the immune system. In this dissertation, we develop three mathematical models to explore these differences in the immune response to acute and chronic infections …
-
Pathological study of the pathways of infection to the intracranial structures from foci of inflammation on the face and in the nasal and nasal accessory cavities
… some twenty years ago to study the literature of acute infection of the leptomeninges from inflammatory foci in the nose, nasal accessory sinuses, and pharynx, the writer was much impressed by the fact that in almost every case published in which the author had mentioned the pathway by which the …
-
Biofilm and Virulence Regulation of the Cystic Fibrosis Associated Pathogens, Stenotrophomonas maltophilia and Pseudomonas aeruginosa
… CF patients often suffer from chronic bacterial infections within the lungs, wherein the bacteria persist as a biofilm, leading to poor prognosis. Two of these pathogens, Stenotrophomonas maltophilia and Pseudomonas aeruginosa, are often found in the lungs of patients with CF and are an …
-
A prospective investigation of cognitive-behavioural models of irritable bowel and chronic fatigue syndromes: implications for theory, classification and treatment
… from this model were assessed in two acutely ill samples. The significance and relative importance of these variables with regard to the development of post-infectious IBS and CFS were then examined. At the same time, information was gathered to assess the appropriateness of an overall …
-
Stenotrophomonas maltophilia induzierte Endophthalmitis
… examined before and during, 1 and 6 months after acute PE. Results: Before cataract surgery visual acuity was <0,3 in 12/26 patients (46%), during acute infection in 20/26 (77%), after 1 month in 6/26 patients (23%) and after 6 months in 3/24 patients (11,5%) (p<0,001). Within 6 months after PE, …
-
HIV-1 strain-specific neutralizing antibody responses and the dynamics of viral evolution
… who developed bnAb responses from one year post infection. We used single genome amplification (SGA) to characterize viral evolution at four time points: at acute infection; after the development of strain-specific neutralizing responses; at the first detection of the broadly neutralizing …
-
Development and Utilization of Novel Immunologic Reagents for Infectious Disease Studies in the Guinea Pig
Genital herpes disease caused by HSV-2 infections is a worldwide public health epidemic with a global prevalence estimated at 500 million. These individuals serve as a reservoir for transmission of the virus to naïve individuals resulting in a global increase of 26 million new infections per year. …
-
Guanabenz Reduces Hyperactivity and Neuroinflammation Caused by Latent Toxoplasmosis in Mice
… parasite that causes persistent, lifelong infection in one-third of humans worldwide. The parasite converts from a lytic, actively replicating form (tachyzoite) into a latent tissue cyst form (bradyzoite) that evades host immunity and is impervious to current drugs. While acute infection …
-
Paneth Cell-Dependent Intestinal Homeostasis During T. Gondii Infection
… such as inflammatory bowel disease (IBD) and infection. The protozoan parasite Toxoplasma gondii triggers severe small intestinal immunopathology that recapitulates many characteristics of IBD such as elevated IFN-g and microbiota-mediated inflammation, along with disappearance of Paneth …
-
ANIMAL MODELS FOR BEHAVIORAL CHANGES OR HEARING LOSS UPON ACUTE VIRUS INFECTIONS
… disease, typically a chronic complication of an acute illness. Neurological sequelae are those complications involving the brain and central nervous system and can include intellectual disability, seizures, emotional instability, vision loss, and hearing loss. Although many viral infections may …
-
Molecular Mechanisms Behind Sars-Cov-2 Induced Host Genome Restructuring
<p>Severe Acute Respiratory Syndrome Coronavirus -2 (SARS-CoV-2) has caused unprecedented morbidity and mortality worldwide.<strong> </strong>There are two pathophysiological hallmarks associated with severe patient outcomes after SARS-CoV-2 acute infection, namely delayed/weakened interferon …
Page 1 of 3