Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Acute Viral Infection"”.
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Redox Regulation of T cell Activation and Function During Viral Infection
… was decreased in effector cells at day 8 post acute viral infection. Deletion of PrdxII increased ROI, proliferation, and death during in vitro division. Activated CD8+ T cells from PrdxII deficient mice were resistant to Fas-Ligand induced apoptosis, but susceptible to death-induced by TCR …
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Multigenic Regulation of the Shutdown of Immune Responses
… of antigen-specific memory CD8+ T cells. During acute viral infection, large numbers of effector CD8+ T cells are generated. Following viral clearance, the majority of these cells undergo apoptosis during the contraction phase, while the surviving cells differentiate into memory CD8+ T cells that …
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USING UNSUPERVISED LEARNING TECHNIQUES TO UNDERSTAND CD8+ T CELL DIFFERENTIATION DURING VIRAL INFECTION AND TUMOR DEVELOPMENT
… during latency differ from those primed in acute or chronic viral infection, we adoptively transferred naive P14 CD8+ T cells into uninfected recipients, and compared their phenotype and function following infection with the Armstrong (acute) or Clone 13 (chronic) strains of LCMV, or MHV68 …
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The essential, nonredundant roles of RIG-I and MDA5 in detecting and controlling West Nile virus infection
… are critical components of host defense against infection. Activation of cell-intrinsic immunity and optimal priming of adaptive immunity against West Nile virus (WNV), an emerging vector-borne virus, depends on recognition by RIG-I and MDA5, cytosolic pattern recognition receptors (PRRs) of the …
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The Development and Function of Memory Regulatory T Cells
… roles for TReg cells during pathogen infection, which will be the focus of this thesis.</p><p>Studies examining TReg cells during infection have largely focused on chronic infection models. These studies have shown that TReg cells can affect responses to pathogens in various ways that …