NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 75 for “"Acute Myeloid Leukemia (AML)"”.

  1. Preclinical Studies of A Novel Idh1 Inhibitor In Acute Myeloid Leukemia (Aml)

    Salama, Vivian, <p>https://orcid.org/0000-0002-4870-4635</p>2021

    … Isocitrate Dehydrogenase 1 (IDH1) inhibitor in Acute Myeloid Leukemia, it</strong> <strong>is more effective than Ivosidenib (AG120) and has a potent anti-leukemic effect against IDH1 mutant acute myeloid leukemia in combination with Venetoclax (ABT-199).</strong></p> <p>Acute myeloid Leukemia …

    uthsc Repository record

  2. An Investigation into the Potential of Cell Therapies for Acute Myeloid Leukemia (AML) Treatment

    Eckstrom, Amanda, <p>0009-0001-9511-3408</p>2026

    <p>Despite recent advances in acute myeloid leukemia (AML) treatment, curative rates remain poor with high rates of relapse and many patients are unable to tolerate the intensive chemotherapy standard of care regimen. Cell therapies have shown great success against hematologic malignancies but face …

    uthsc Repository record

  3. Generation of recombinant SNAP-tag based antibody fusion proteins for immunotherapy of acute myeloid leukemia (AML)

    Molope, Gomolemo AtlegangDepartment of Pathology2025

    Acute Myeloid Leukemia (AML) remains a significant challenge to cure. In Africa, Leukemia is among the ten most prevalent cancers. The lack of an updated registry, medical technologies that provide timely diagnosis, and convenient access to appropriate treatments would result in an alarming …

    cape-town Repository record

  4. RAS, KIT, FLT3 and JAK2 gene mutations in Acute Myeloid Leukemia (AML) with inv(16) and t(8;21): Incidence and relevance on clinical outcome

    Du, JuanUniversität Ulm

    ulm-diss Repository record

  5. AMP-ACTIVATED PROTEIN KINASE AND ITS ROLE IN THERAPEUTIC RESPONSE IN ACUTE MYELOID LEUKEMIA

    Ghiraldeli, Lais PereiraWake Forest University2018

    Acute myeloid leukemia (AML) is an aggressive cancer of the bone marrow characterized by poor prognosis and resistance to chemotherapy. The way in which cancerous cells are able to metabolically adapt to various physiological and metabolic stressors allows them to thrive and proliferate. A leading …

    wfu Repository record

  6. Studies of the efficacy of Ribonucleotide Reductase inhibition in preclinical models of Acute Myeloid Leukemia in combination with standard and novel therapeutics

    Cook, GuerryWake Forest University2015

    Acute Myeloid Leukemia (AML) is an aggressive disease of the marrow with approximately 18,800 new cases each year. The elderly population represents the bulk of AML patients with a median age of onset of 70. More than 70% of AML patients are over the age of 60, and for this group the 5 year overall …

    wfu Repository record

  7. Treatment Response Prediction in Acute Myeloid Leukemia Patients

    Lambion, Danielle2022

    Predicting acute myeloid leukemia (AML) patient treatment response has the potential to impact clinical decisions. A prediction given at the time of diagnosis for treatment response can assist physicians in making effective treatment decisions and improving patient prognosis. This project aimed to …

    washington Repository record

  8. Role of Abberant Proteolysis in the Pathogenesis of APL

    NG PING PING ANGELA2009

    Acute promyelocytic leukemia (APL), a subtype of acute myeloid leukemia (AML), is caused by PML-RARN1, a fusion protein resulting from chromosomal translocation involving the promyelocytic leukemia (PML) and the retinoic acid receptor N1 (RARN1) genes. PML-RARN1 promotes misfolding of nuclear …

    nus Repository record

  9. Regulation Of Acute Myeloid Leukemia Cell Proliferation By E3 Ubiquitin Ligase DCAF15 Control Of Cohesin Dynamics

    Grothusen, Grant, Peter2023

    … screening approach, we reveal DCAF15 as an acute myeloid leukemia (AML)-biased dependency. Loss of DCAF15 results in suppression of AML through compromised replication fork integrity and consequent accumulation of DNA damage. Accordingly, DCAF15 loss sensitizes AML to replication …

    penn Repository record

  10. Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia

    Ziliotto, Rachel GHThe University of Western Ontario2013

    Acute myeloid leukemia (AML) is associated with mutations or chromosomal translocations in genes encoding transcription factors. PU.1 is a transcription factor that is required for the development of nearly all white blood cell types of the immune system, including B cells, granulocytes, and …

    uwo Repository record

  11. The Role of Cleavage and Polyadenylation Spcific Factor 6 (CPSF6) in Hematopoiesis

    Ye, Fengxi, <p>0009-0009-7833-8320</p>2026

    … is frequently reported in APLL, which is Acute Promyelocytic Leukemia (APL)-like acute myeloid leukemia (AML) and other types of blood diseases associated with abnormal hematopoiesis. CPSF6 is a subunit of the Cleavage Factor I mammalian (CFIm) complex, which regulates post-transcriptional …

    uthsc Repository record

  12. Concomitant Inhibition of Flt3 and Mcl-1 In Flt3 Mutated Acute Myeloid Leukemia

    Panis, Paul, <p>0000-0002-3149-7959</p>2022

    … in preclinical human models of FLT3-ITD mutated acute myeloid leukemia (AML). Acute Myeloid leukemia (AML) is a neoplastic blood disorder defined by a characteristically rapid growth rate and altered behavior of myeloid cells in the bone marrow. The FLT3 receptor is responsible for the upstream …

    uthsc Repository record

  13. AML1/ETO Downregulates the Transcription Factor PU.1 in Acute Myeloid Leukemia

    Vangala, Rajani KanthLudwig-Maximilians-Universität

    AML1-ETO is a fusion protein encoded by the translocation t(8;21) and found in 15% of acute myeloid leukemia patients. Here, we report a negative functional impact of AML1-ETO on the transcriptional activity of PU.1, an important transcription factor for normal myeloid differentiation. We have …

    lmu-germany Repository record

  14. Alternative Mrna Splicing Redefines The Landscape Of Commonly Dysregulated Genes Across The Acute Myeloid Leukemia Patient Population.

    Rivera, Osvaldo Daniel2021

    Most genes associated with acute myeloid leukemia (AML) are mutated in less than 10% of patients, suggesting that alternative mechanisms of gene disruption contribute to this disease. Here, I investigate pre-mRNA splicing events with significant variation and striking coregulation across distinct …

    penn Repository record

  15. The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia

    Au, Yan ZiUniversity of Cambridge2020

    Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy, characterized by the uncontrolled proliferation and differentiation arrest of myeloid progenitors. Chemotherapy has been the front-line treatment for decades and cure remains elusive for the majority of AML patients. …

    cambridge Repository record

  16. Downregulation of Prdm16 Is Critical for HOXB4-mediated Benign HSC Expansion In Vivo

    Yu, Hui2016

    … HSC self- renewal as well as genes involved in myeloid and B cell differentiation. Prdm16, a transcription factor associated with human acute myeloid leukemia (AML), was markedly repressed by HOXB4 but upregulated by HOXA9 and HOXA10, suggesting that Prdm16 downregulation was involved in …

    tenn-hsc Repository record

  17. NON-GENETIC MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA

    MILOVANOVIC, SARAUniversità degli Studi di Milano2022

    Acute Myeloid Leukemia (AML) is the most common type of acute hematological malignancy in adults. 40–60% of patients relapse due to the emergence of cellular resistance to anti- leukemic drugs. Drug resistance in leukemic cells has been associated with intratumoral heterogeneity, among which …

    milano Repository record

  18. Evaluation of the role of autophagy in acute myeloid leukaemic cell differentiation

    Orfali, NinaUniversity College Cork2017

    Acute myeloid leukemia (AML) is a malignancy characterized by the accumulation of white blood cell precursors in the bone marrow and circulation. Treatment regimens for this disease are notoriously toxic and survival is poor. Pharmacological overcoming the differentiation block seen in AML is an …

    cork Repository record

  19. A CELL CYCLE CLOCK REGULATES THE EPIGENETIC LANDSCAPE OF AML CELLS AND DETERMINES SENSITIVITY TO LSD1 INHIBITION

    HAYATIGOLKHATMI, KOUROSHUniversità degli Studi di Milano2023

    Acute Myeloid Leukemia (AML) remains a complicated challenge in oncology, characterized by a complex interplay of factors that contribute to poor survival rates and resistance to chemotherapy and targeted therapies. This study presents a novel approach to unravel the layers of AML biology and …

    milano Repository record

  20. EXPLORING THE MUTATIONAL LANDSCAPE OF MITOCHONDRIAL GENOME IN HEMATOLOGIC MALIGNANCIES

    DAVINI, ALESSANDROUniversità degli Studi di Milano2025

    … with diffuse large B-cell lymphoma (DLBCL), acute myeloid leukemia (AML) and chronic lymphocytic leukemia (CLL), alongside two cohorts of healthy donors. We identified 21, 19, and 16 disease-specific heteroplasmic mtDNA missense mutations in DLBCL, AML, and CLL, respectively. These …

    milano Repository record

Page 1 of 4