NDLTD logo NDLTD Union Catalog and Global ETD Search

Global ETD Search

Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.

Results

Showing 1 to 20 of 117 for “"Acute Myeloid Leukemia"”.

  1. Deciphering the Pathogenesis of Acute Myeloid Leukemia

    Reckzeh, KristianDivision of Molecular Medicine and Gene Therapy, Dept of Laboratory Medicine2012

    Acute myeloid leukemia (AML) is a malignant disorder of the blood system. Hematopoietic stem cells (HSCs) supply and maintain this system by differentiating via intermediates into lineage-restricted progenitors that strongly proliferate to keep up with the high turn-over of mature blood cells. In …

    lund Repository record

  2. Treatment Response Prediction in Acute Myeloid Leukemia Patients

    Lambion, Danielle2022

    Predicting acute myeloid leukemia (AML) patient treatment response has the potential to impact clinical decisions. A prediction given at the time of diagnosis for treatment response can assist physicians in making effective treatment decisions and improving patient prognosis. This project aimed to …

    washington Repository record

  3. NON-GENETIC MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA

    MILOVANOVIC, SARAUniversità degli Studi di Milano2022

    Acute Myeloid Leukemia (AML) is the most common type of acute hematological malignancy in adults. 40–60% of patients relapse due to the emergence of cellular resistance to anti- leukemic drugs. Drug resistance in leukemic cells has been associated with intratumoral heterogeneity, among which …

    milano Repository record

  4. Immunogenicity of leukemia stem cells in acute myeloid leukemia

    Zhang, LuUniversität Ulm

    ulm-diss Repository record

  5. The Cell-Essentiality of KAT7 in Acute Myeloid Leukemia

    Au, Yan ZiUniversity of Cambridge2020

    Acute myeloid leukemia (AML) is an aggressive hematopoietic malignancy, characterized by the uncontrolled proliferation and differentiation arrest of myeloid progenitors. Chemotherapy has been the front-line treatment for decades and cure remains elusive for the majority of AML patients. …

    cambridge Repository record

  6. CELLULAR AND MOLECULAR MECHANISMS OF CHEMORESISTANCE IN ACUTE MYELOID LEUKEMIA

    FRASCOLLA, SIMONEUniversità degli Studi di Milano2025

    Acute Myeloid Leukemia (AML) remains an incurable disease, with a 5-year survival rate below 30%. While the introduction of new therapeutic approaches, such as targeted therapies and immunotherapy, has had a modest impact on AML prognosis, the standard treatment of AML is still based on …

    milano Repository record

  7. Targeting Apoptotic Pathways to Overcome Drug Resistance In Acute Myeloid Leukemia

    Pan, Rongqing2018

    … find that BCL-2 protein is highly expressed in acute myeloid leukemia (AML) cells. BCL-2–specific inhibitor ABT-199 potently induces mitochondrial apoptosis in AML cells and effectively kills AML stem/progenitor cells. Our biomarker studies demonstrate that both BH3 profiling and the expression …

    uthsc Repository record

  8. Aberrant epigenetics in the molecular pathogenesis of human acute myeloid leukemia

    Scott, Stuart AlexanderUniversity of Saskatchewan2005

    … silenced by promoter hypermethylation in human acute myeloid leukemia (AML) and to study the mechanism of promoter hypermethylation mediated gene silencing. Interestingly, the cyclin dependent kinase inhibitor p15 was found to be methylated at a high frequency in AML patients and cell lines in …

    sask Repository record

  9. Inhibition of Mitochondrial Translation as a Therapeutic Strategy for Acute Myeloid Leukemia

    Skrtic, Marko2013

    … translation as a therapeutic strategy for acute myeloid leukemia Marko Škrtić Doctor of Philosophy Institute of Medical Science University of Toronto 2012 Abstract Intro: Acute myeloid leukemia (AML) therapies have remained unchanged for 20 years, and thus new therapies are needed. …

    toronto-retro Repository record

  10. Preclinical Studies of A Novel Idh1 Inhibitor In Acute Myeloid Leukemia (Aml)

    Salama, Vivian, <p>https://orcid.org/0000-0002-4870-4635</p>2021

    … Isocitrate Dehydrogenase 1 (IDH1) inhibitor in Acute Myeloid Leukemia, it</strong> <strong>is more effective than Ivosidenib (AG120) and has a potent anti-leukemic effect against IDH1 mutant acute myeloid leukemia in combination with Venetoclax (ABT-199).</strong></p> <p>Acute myeloid Leukemia …

    uthsc Repository record

  11. Oncogenic roles of RAS in acute myeloid leukemia cooperated with Mll-AF9.

    Kim, Won-il2008

    … hematopoietic progenitor cells (HPC) as well as myeloid and lymphoid lineages by live mouse imaging and relative light unit measurement before or after treating Vav-tTA ; TRE -luciferase co-transgenic mice with doxycycline (Dox). We found that B cells in the bone marrow and T cells in the thymus …

    umn Repository record

  12. Characterizing the functional role of argonaute protein PIWIL4 in acute myeloid leukemia

    Bamezai, ShivaUniversität Ulm

    ulm-diss Repository record

  13. Cytogenetic abnormalities in Acute Myeloid Leukemia in Sweden. A population based study.

    Lazarevic, VladimirStam Cells Centrum (SCC)2015

    The impact of cytogenetic findings in AML was analyzed in the large population-based Swedish AML registry. Karyotypic patterns differed by age: t(8;21), inv(16) and t(11q23) were more common in younger patients, whereas loss of 5q, 7q and 17p, monosomal karyotype (MK) and complex karyotype (CK) …

    lund Repository record

  14. AML1/ETO Downregulates the Transcription Factor PU.1 in Acute Myeloid Leukemia

    Vangala, Rajani KanthLudwig-Maximilians-Universität

    … by the translocation t(8;21) and found in 15% of acute myeloid leukemia patients. Here, we report a negative functional impact of AML1-ETO on the transcriptional activity of PU.1, an important transcription factor for normal myeloid differentiation. We have demonstrated that AML1-ETO interacts …

    lmu-germany Repository record

  15. Gene Repression and Cell Cycle Regulation by PU.1 in Acute Myeloid Leukemia

    Ziliotto, Rachel GHThe University of Western Ontario2013

    Acute myeloid leukemia (AML) is associated with mutations or chromosomal translocations in genes encoding transcription factors. PU.1 is a transcription factor that is required for the development of nearly all white blood cell types of the immune system, including B cells, granulocytes, and …

    uwo Repository record

  16. Identifying Mechanisms Of Resistance And Potential Therapeutic Targets For Pediatric Acute Myeloid Leukemia

    Caldwell, John Timothy2014

    <p>Acute myeloid leukemia (AML) is a potentially devastating disease that can affect people of all ages. While there are certain patient groups that typically have favorable outcomes, in the pediatric population, overall survival (OS) is approximately 70%, leaving much progress to be made. Children …

    wayne-thes Repository record

  17. Concomitant Inhibition of Flt3 and Mcl-1 In Flt3 Mutated Acute Myeloid Leukemia

    Panis, Paul, <p>0000-0002-3149-7959</p>2022

    … in preclinical human models of FLT3-ITD mutated acute myeloid leukemia (AML). Acute Myeloid leukemia (AML) is a neoplastic blood disorder defined by a characteristically rapid growth rate and altered behavior of myeloid cells in the bone marrow. The FLT3 receptor is responsible for the upstream …

    uthsc Repository record

  18. AMP-ACTIVATED PROTEIN KINASE AND ITS ROLE IN THERAPEUTIC RESPONSE IN ACUTE MYELOID LEUKEMIA

    Ghiraldeli, Lais PereiraWake Forest University2018

    Acute myeloid leukemia (AML) is an aggressive cancer of the bone marrow characterized by poor prognosis and resistance to chemotherapy. The way in which cancerous cells are able to metabolically adapt to various physiological and metabolic stressors allows them to thrive and proliferate. A leading …

    wfu Repository record

  19. THE METHIONINE CYCLE AS A NOVEL THERAPEUTIC TARGET IN NPM1C DRIVEN ACUTE MYELOID LEUKEMIA

    POLAZZI, ANDREAUniversità degli Studi di Milano2023

    Acute myeloid leukemia (AML) is the most common leukemia in adults and its prognosis is usually poor. Patients are still treated with conventional chemotherapy, which induces disease cure in <40% of patients. The main culprit of therapy failure is the genomic and biological heterogeneity of the …

    milano Repository record

  20. In-vivo investigation of resveratrol as a preventive for radiation-induced acute myeloid leukemia

    Carsten, Ronald E., author, Ullrich, Robert L., advisorColorado State University. Libraries2008

    … mutation of the remaining allele leads to acute myeloid leukemia in CBA mice.

    colostate Repository record

Page 1 of 6