Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Acute Lymphoblastic Leukaemia (ALL)"”.
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The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)
Relapsed ALL remams one of the most common causes of death from disease in children. Broad-range drug resistance is often associated with relapse, although its underlying molecular mechanisms remained poorly understood. The aim of this thesis was to establish an in vivo model using the non-obese …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
… expected to be overweight by 2035. Children with ALL who are obese at diagnosis are less likely respond to standard cancer treatment, it is more difficult to achieve a complete remission in obese children, they are subject to higher minimal residual disease risk, poorer event free survival and …
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On the detection of seasonal variation in the onset of disease
… summary data from published studies of acute lymphoblastic leukaemia (ALL). In addition, variation using individual dates of onset of ALL (in children and adults) from Singapore, Sweden and USA are examined. No clear picture emerges with respect to the seasonality of ALL although …
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Frequency of leukemia types and flowcytometric immunophenotypic characterization of acute lymphoblastic leukemia presenting at the university teaching hospital, Lusaka
The Frequency of Leukaemia types vary in different geographical locations and between age groups and gender. The diagnosis of Leukaemia at UTH is done by Morphological examination of blood or bone marrow smears only. Immunophenotyping is a further diagnostic tool that can be performed to diagnose …
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Frequency of leukemia types and flowcytometric immunophenotypic characterization of acute lymphoblastic leukemia presenting at the university teaching hospital, Lusaka
The Frequency of Leukaemia types vary in different geographical locations and between age groups and gender. The diagnosis of Leukaemia at UTH is done by Morphological examination of blood or bone marrow smears only. Immunophenotyping is a further diagnostic tool that can be performed to diagnose …
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Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia
… was identified<br/>as a novel and prognositically important acquired chromosomal abnormality in<br/>childhood acute lymphoblastic leukaemia (ALL). It is defined by multiple copies<br/>of the RUNX1 gene, as seen by fluorescence in situ hybridisation (FISH), localised<br/>to a single abnormal …
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Analysis of drug resistance and the role of the stem cell niche in leukaemia
Glucocorticoids and etoposide are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoblasts through the glucocorticoid receptor (GR) and p53. However, glucocorticoid resistance, cell death mechanisms and the contribution of the bone marrow microenvironment to drug …
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Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most …
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Role of Actin and its regulating proteins in drug response
… in the treatment of childhood neuroblastoma and acute lymphoblastic leukaemia (ALL). Resistance to these agents can be a major clinical problem and mechanisms mediating resistance are not fully understood. Previous studies have reported an association between the actin cytoskeleton and resistance …
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Elucidating oncogenic mechanisms in human B cell malignancies
… work investigating haematological malignancies; Acute Lymphoblastic Leukaemia (ALL) and Diffuse Large B Cell Lymphoma (DLBCL). Firstly, Pre-B ALL represents the most common paediatric malignancy and despite increasingly improved outcomes for patients, ~ 20% of all patients diagnosed with ALL …
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Analysis of NEIL3 expression : a possible resistance factor to cancer chemotherapy in paediatric cancer cells
… both single- and double-stranded DNA. Additionally, NEIL3 has recently been shown to release oxidised bases from telomeric regions of DNA. While NEIL3 shows a restricted expression pattern in normal human cells, previous studies have shown that NEIL3 is highly expressed in various cancer cell …
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Responses to Tumour initiating factors and Regulation of Normal and Malignant Haematopoiesis
… in the Vegfa promoter has been deleted at both alleles, thereby inhibiting HIF-binding and subsequent activation of Vegfa expression following hypoxia. We show that hypoxic regulation of Vegfa expression within the haematopoietic system affects haematopoietic differentiation and numbers of HSCs …
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Zur epigenetischen Inaktivierung der Wnt-Antagonisten SFRP-1, -2, -4 und -5 bei der Akuten Myeloischen Leukämie
Acute myeloid leukaemia (AML) originates in the transformation of hematopoietic stem cells, leading to clonal proliferation of immature progenitor cells and severe multilineage bone marrow suppression. In addition to numerous genetic aberrations in AML, it has become evident that epigenetic …
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The effect of degradation on the efficacy and utility of the biopharmaceutical enzyme Erwinia Chrysanthemi L-Asparaginase
… or degraded protein variants comprise a small percentage of a biopharmaceutical protein sample, so it is difficult to assess their true impact on product quality and clinical efficacy. The assumption that biopharmaceutical producers adopt is that partially degraded or aggregated protein …
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Identification of Randomized Trials for Inclusion in Meta-Analyses of Treatments for Childhood Acute Lymphoblastic Leukaemia, and Investigation of Factors Leading to Publication Bias
… of randomized trials identified by the Childhood Acute Lymphoblastic Leukaemia (ALL) Collaborative Group was used. This consists of 149 trials comprising 243 randomized comparisons (randomizations), starting prior to 1 January 1988, reported in 257 articles, published prior to 1 January 2000. Each …
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Identification of glucocorticoid-regulated genes and inferring their network focused on the glucocorticoid receptor in childhood leukaemia, based on microarray data and pathway databases
Acute lymphoblastic leukaemia (ALL) has the highest mortality rate in childhood cancer. Glucocorticoids (GCs) have been used as chemotherapeutic drugs for children with ALL for more than 50 years. GCs induce apoptosis in lymphoid cells. However, little is known about the molecular mechanism of …