Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"Acute Lymphoblastic Leukaemia"”.
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Acquired abnormalities of chromosome 21 in acute lymphoblastic leukaemia
… chromosomal abnormality in<br/>childhood acute lymphoblastic leukaemia (ALL). It is defined by multiple copies<br/>of the RUNX1 gene, as seen by fluorescence in situ hybridisation (FISH), localised<br/>to a single abnormal duplicated chromosome 21 [dup(21)]. The morphological<br/>form of …
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Late effects of treatment in survivors of childhood acute lymphoblastic leukaemia
… survival and probable cure have become norms in acute lymphoblastic leukaemia of childhood. The adverse effects of treatment for leukaemia are diverse and complex. In many cases, treatment effects come to light 1 ong after the end of therapy. These so-ca 11 ed 1 ate effects (which are yet obscure …
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Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia
Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it was the first cancer to be cured by drugs. It is therefore an important model upon which concepts of chemotherapy in other malignancies have been developed. Methotrexate is a major component of most …
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Role of Rap and Rho GTPases in T-acute lymphoblastic leukaemia cell adhesion and migration
T-acute lymphoblastic leukaemia (T-ALL) is a common childhood cancer. Multiple genetic mutations have been identified in T-ALL patients. The most common is the mutation of the NOTCH 1 oncogene occurring in more than 50% of patients. Poor prognosis has often been shown to correlate with the …
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Chracterisation of Chromosomal Aberrations in Acute Lymphoblastic Leukaemia Patients Attending the University Teaching Hospital in Lusaka
Acute lymphoblastic leukaemia is a malignant disease that evolves as a result of mutation of lymphoid precursor cells. The World Health Organization recognizes that the genetic analysis of leukaemia has prognostic and therapeutic implications. Cytogenetic and molecular studies provide important …
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The development of an in vivo model to study the biology and treatment of childhood acute lymphoblastic leukaemia (ALL)
… diagnosis or relapse. Mice were inoculated with leukaemia cells from patients' biopsies and engraftment was monitored by the proportion of human CD45+ cells in the blood. Successful leukaemia engraftment was achieved for 20/20 patient biopsies. Continuous passaging of ten xenografts has also been …
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Genomics, Diagnosis, Novel Targeted Therapies and Characterisation of the Drivers of Relapse in Philadelphia Chromosome-Like Acute Lymphoblastic Leukaemia
… on Philadelphia chromosome-like (BCR::ABL1-like) acute lymphoblastic leukaemia (Ph-like ALL), a subtype of B-cell ALL recently recognised as a distinct entity. The genomic drivers of Ph-like ALL are diverse. This thesis emphasises investigation of the JAK/STAT class of lesions. Ph-like ALL …
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Improving outcomes for obese children with Acute Lymphoblastic Leukaemia (ALL): a clinical collaboration to understand the influence of obesity on treatment success.
Cancer Research UK has reported that obesity is the second highest risk factor for developing cancer after smoking. Studies suggest that almost three quarters of people are expected to be overweight by 2035. Children with ALL who are obese at diagnosis are less likely respond to standard cancer …
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Modelling the effect of loss of function CREBBP mutations in the evolution and treatment of B cell acute lymphoblastic leukaemia (B-ALL)
… exceptional advances in comprehending B cell acute lymphoblastic leukaemia (B-ALL) pathogenesis and the use of novel treatments, there are still some subtypes classified as high-risk patients and many other who relapse. In this thesis I seek to understand the role of CREBBP mutations in the …
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Identification of Randomized Trials for Inclusion in Meta-Analyses of Treatments for Childhood Acute Lymphoblastic Leukaemia, and Investigation of Factors Leading to Publication Bias
… of randomized trials identified by the Childhood Acute Lymphoblastic Leukaemia (ALL) Collaborative Group was used. This consists of 149 trials comprising 243 randomized comparisons (randomizations), starting prior to 1 January 1988, reported in 257 articles, published prior to 1 January 2000. Each …
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Frequency of leukemia types and flowcytometric immunophenotypic characterization of acute lymphoblastic leukemia presenting at the university teaching hospital, Lusaka
The Frequency of Leukaemia types vary in different geographical locations and between age groups and gender. The diagnosis of Leukaemia at UTH is done by Morphological examination of blood or bone marrow smears only. Immunophenotyping is a further diagnostic tool that can be performed to diagnose …
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Frequency of leukemia types and flowcytometric immunophenotypic characterization of acute lymphoblastic leukemia presenting at the university teaching hospital, Lusaka
The Frequency of Leukaemia types vary in different geographical locations and between age groups and gender. The diagnosis of Leukaemia at UTH is done by Morphological examination of blood or bone marrow smears only. Immunophenotyping is a further diagnostic tool that can be performed to diagnose …
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An investigation of the role of TRIB2 in steady state and stressed haematopoiesis
… thymocytes. In an experimental murine T-cell acute lymphoblastic leukaemia (T-ALL) model, Trib2-/- mice had reduced latency in vivo which associated with aggressive T-ALL phenotypes and impaired activation of mitogen-activated protein kinase. Gene set enrichment analysis showed that TRIB2 …
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On the detection of seasonal variation in the onset of disease
… summary data from published studies of acute lymphoblastic leukaemia (ALL). In addition, variation using individual dates of onset of ALL (in children and adults) from Singapore, Sweden and USA are examined. No clear picture emerges with respect to the seasonality of ALL although …
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Investigating Tumour-Immune Cell Interactions in Paediatric Malignancies
… rate reaching nearly 80%. However, certain leukaemias and solid tumours, as well as metastatic and relapsed cancers, remain resistant to current therapeutic approaches. These patients endure aggressive therapies and severe treatment-related toxicities, often with little chance of a cure. …
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Isolation and characterisation of novel glycosaminoglycan-like polysaccharides derived from marine molluscs with antiproliferative activity
… cancer cell lines, which are chronic myelogenous leukaemia, relapsed acute lymphoblastic leukaemia and mesothelioma of the pleural cavity with asbestos exposure. Structural analysis has confirmed the presence of glycosaminoglycan-like polysaccharides in cockle extracts with potent …
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Analysis of drug resistance and the role of the stem cell niche in leukaemia
Glucocorticoids and etoposide are used to treat acute lymphoblastic leukaemia (ALL) as they induce death in lymphoblasts through the glucocorticoid receptor (GR) and p53. However, glucocorticoid resistance, cell death mechanisms and the contribution of the bone marrow microenvironment to drug …
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Tetrahydrobiopterin Metabolism in Mental Retardation
… urine THB level with low blood DHPR activity. Acute oral phenylalanine loading in man produces a transient rise in total biopterin and in the rat a decrease in brain per cent THB, Reduced THB synthesis with low biopterin level and high neopterin-biopterin ratio was noted in senile dementia …
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