Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Acute Coronary Syndromes"”.
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Risk stratification by analysis of electrocardiographic morphology following acute coronary syndromes
Patients who have suffered an acute coronary syndrome (ACS) are at elevated risk of future adverse events, including fatal arrhythmias or myocardial infarction. Risk stratification--he identification of high-risk patients--s an important step in determining who is most likely to benefit from …
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Clinical, Invasive and Non-Invasive Factors Affecting Outcomes in Patients with Acute Coronary Syndromes
… factors affecting outcomes after percutaneous coronary intervention (PCI), the most common interventional procedure performed, were examined. To constrain procedural costs, selective criteria for drug-eluting stents (DES), which reduce restenosis, were developed in 2003 at Liverpool Hospital, …
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Targeting Inflammation in Atherosclerosis: The Role of Low-dose Interleukin 2 in Acute Coronary Syndromes
The primary aetiology of acute coronary syndromes (ACS) is atherosclerosis. Historically, atherosclerosis was thought to be driven by traditional risk factors, such as hyperlipidaemia. However, we now know that inflammation plays a central role in its pathophysiology. In ACS there is an acute flare …
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Association of adverse cardiovascular outcomes with weighted morphologic variability following non-ST-elevation acute coronary syndromes
Patients who have had an acute coronary syndrome (ACS) are at a relatively high risk of having subsequent adverse cardiac events. Several electrocardiographic (ECG) measures such as heart rate variability, heart rate turbulence, deceleration capacity, T-wave altemans, and morphologic variability …
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Evaluating the performance of the GRACE and TIMI risk scores in acute coronary syndromes: a South African cohort
… adverse cardiac events (MACE) in patients with Acute Coronary Syndromes (ACS). The performance of GRACE and TIMI scores in a setting where most ST-elevation myocardial infarction (STEMI) patients receive thrombolytic reperfusion therapy after 6 hours and a considerable proportion of non-ST …
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The prevalence of dysglycaemia in acute coronary syndromes : can the emergency department contribute in identifying those at high risk of coronary artery disease?
Includes bibliographical references (leaves 48-56).
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Molecular and Cellular Signaling Mechanisms Elucidating Aldose Reductase Mediated Ischemia-Reperfusion Injury in the Myocardium
… overview of the pathophysiology associated with acute coronary syndromes, the mechanisms of normal myocardial substrate metabolism, and how metabolism is altered under ischemic conditions. Specific chapters in this dissertation aim to elucidate whether AR pathway mediated I/R injury is linked to …
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Mode of transport to hospital among patients with ST Elevation Acute Myocardial Infarction (STEMI) in the Emirate of Abu Dhabi: correlates, physician and patient attitudes, and associated clinical outcomes
Introduction: Acute coronary syndromes, including ST-elevation myocardial infarction (STEMI), are a leading cause of morbidity and mortality worldwide. Existing research shows that prehospital care provided by emergency medical services (EMS) can significantly improve outcomes. However, EMS remains …
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Achievement of secondary prevention goals 6 to 9 months after Acute Coronary Syndrome : a retrospective, cross-sectional analysis
… [ARBs]) and smoking cessation in patients after acute coronary syndromes. At present, little is known about adherence to medication and smoking behaviour after discharge in South Africa. This information is essential to optimising both in-patient care and post-discharge planning of these …
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The development and application of an in vitro model of coronary lesion thrombosis
… luminal occlusion may rapidly occur. The coronary vascular bed is a life-sustaining environment in which pathological thrombosis can lead to devastating outcomes such as acute coronary syndromes or post-interventional thrombosis. In order to study these coronary thrombotic reactions, it is …
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Psychosocial and psychophysiological characteristics of atrial fibrillation patients and their influence on the prothrombotic state and prognosis
… (AF), and (2) determine the effects of acute mental and postural stress, and hydration status on indices haemorhelogy, endothelial function, and platelet reactivity. Symptoms of depression (BDI scores > 10) persisted in 38% of patients with AF, with elevated state and trait anxiety (STAI …
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Genotype- versus phenotype-directed personalization of antiplatelet treatment in Koreans with coronary artery disease undergoing coronary stenting
… Sixty-five patients undergoing percutaneous coronary intervention for non-ST elevation acute coronary syndromes were randomly assigned to genotype- or phenotype-directed treatment. All patients were screened for the CYP2C19 *2, *3, or *17 alleles by using Verigene CLO assay (Nanosphere, …
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Clinical profiles and outcomes of patients receiving acute renal replacement therapy in the cardiac intensive care unit at a South African tertiary centre
… Cardiac Intensive Care Unit (CICU) will develop Acute Kidney Injury (AKI) and some of these patients receive Renal Replacement Therapy (RRT). The clinical profiles and outcomes of CICU patients receiving RRT in resource constraint settings like South Africa is unknown. Objectives The objectives …
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Cardioprotective mechanisms targeting thiol redox homeostasis and mitochondrial bioenergetics
Coronary heart disease is a leading cause of death in the United States, totaled mostly by deaths associated with myocardial infarction and fatal ventricular arrhythmias. The inability to predict the occurrence of these pathologies due to their sudden and transient etiologies has hindered …
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Improving outcomes in patients with coronary heart disease using national registers and platelet function testing
… to evaluate different contemporary approaches in coronary care with regard to mortality and myocardial infarction. Methods: The thesis consists of 6 papers with 4 papers evaluating different exposures and their outcomes (clopidogrel pre-treatment, 5 different anti-platelet protocols, ticagrelor …
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The Epidemiology and Management of Ischaemic Heart Disease in New Zealand: A Series of National Routine Health Data-Linkage Studies
… three studies investigated long-term statin use, acute revascularisation and case fatality in people hospitalised with acute coronary syndromes (ACS). The latter five studies were focused on all hospitalised and fatal IHD, examining pre-hospital IHD case fatality and contemporary trends in IHD …
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STEMI Management and Outcomes at a Regional Hospital in Guatemala
… In Guatemala, in-hospital mortality from acute coronary syndromes markedly exceeds global averages due to delayed presentation, limited reperfusion access, and systemic resource constraints. Hospital Nacional de San Benito (HNSB), the main public referral hospital for rural Petén, operates …
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Atrial fibrillation – on its trigger mechanisms, risks and consequences
… Of 2335 consecutive patients admitted with acute coronary syndromes (ACS), 442 had known AF (n=204), new AF at admission (n=54) or developed new AF during hospitalization (n=184). The short- and long-term mortality and morbidity were followed in patients with and without AF, and were related …
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A Fluid Structure Interaction Model Of Intracoronary Atherosclerotic Plaque Rupture
… superimposed thrombosis is the primary cause of acute coronary syndromes of unstable angina, myocardial infarction and sudden death. Although intensive studies in the past decade have shed light on the mechanism that causes unstable atheroma, none has directly addressed the clinical observation …
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Takotsubo Syndrome: Precipitants, Clinical Course and Emerging Treatments
… Syndrome(TTS) presents similarly to that of acute coronary syndromes(ACS). Recent evidence has demonstrated that not only is TTS a common condition, like ACS, it is also associated with significant morbidity and mortality in the short- and long-term. It is now also recognised that there are …
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