Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Activity-based probe"”.
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Design and Synthesis of an E3 ligase Activity-Based Probe and its Application for the Discovery of a New Class of E3 Ligase
… currently no effective tools for profiling their activity. Herein, a new class of E3 activity-based probe (ABP) is presented which is built by re-engineering ubiquitin (Ub)-charged E2 conjugating enzymes. The utility of these probes has been demonstrated by the rapid dissection of the activation …
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Organotellurium Reagents for Multiparametric Interrogation of Dynamic Biology
… a single cell. Unlike traditional fluorescence-based flow cytometry, which suffers from spectral overlap of fluorophore reporters, MC allows for simultaneous measurement of a massive number of parameters—limited only by the number of unique heavy isotopes on the periodic table. Since its …
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Chemical biology of matrix metalloproteases
… it is imperative to synthesise small molecule/probes which can selectively target a particular MMP instead of those which exhibit broad spectrum inhibition against the whole family. In this project, we aim at profiling MMPs substrate specificities in a high-throughput manner using small …