Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Activity dependent transcription"”.
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A Neuroprotective Role for Mir-1017, a Non-Canonical Mirna
<p>miRNAs are post-transcriptional regulators of gene expression, with numerous being involved in neurobiology. Within the human genome a quarter of the identified miRNA loci derive from a class of miRNAs termed tailed mirtrons. Despite the identification of this large population of miRNA, no …
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The Role of MEF2 Transcription Factors in Neocortical Circuit and Synapse Development In Vivo
… development requires postnatal experience and transcription. Neocortical neurons migrate to their proper layers and then undergo robust synapse proliferation to maximize contacts with presynaptic partners. Synapses are dynamic structures subjected to an equilibrium of formation and elimination …
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Identification and Characterization of Novel Mechanisms of Functional and Structural Synapse Remodeling: Focus on Vav Guanine Nucleotide Exchange Factors and MEF2 Transcription Factors
… pruned during adolescence in a sensory- and activity-dependent mechanism. The brain also exhibits experience-dependent synaptic modifications that may enhance or weaken functional synapse strength. Investigation of numerous neurodevelopmental and psychiatric disorders reveals dysfunctions in …
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Serum Response Factor Regulates Multiple Aspects of Central Nervous System Development
SRF is a highly evolutionary conserved activity-dependent transcription factor. Previous studies have shown that neuron-specific deletion of SRF results in deficits in tangential cell migration, guidance-dependent circuit assembly, activity-dependent gene expression, and synaptic plasticity in the …