Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 121 for “"Activity dependent"”.
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Transcriptional Mechanisms Underlying Neuronal Activity-Dependent Plasticity
Pages 1-110 are misnumbered as pages 2-111.
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Activity-Dependent Regulation of Inhibition from Different Inhibitory Subtypes
Neuronal activity, in the form of action potential firing, is critical in the maturation and maintenance of neocortical circuitry. A negative feedback mechanism by which neuronal circuits adapt to changing levels of average activity on a time scale of hours to days is known as homeostatic …
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Activity-Dependent Plasticity in the Murine Olfactory Bulb Neurons
… and is heavily modulated by the duration of activity perturbation (Wen and Turrigiano, 2024). This thesis aimed to investigate how different neuron types and subtypes in mammalian pre-cortical sensory circuits are modulated by sensory deprivation in a cell-type-specific and …
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Activity Dependent Trans-synaptic Tracing Of Neural Circuits In Drosophila
… We have developed HA-Tango-trace, an activity-dependent trans-synaptic tracer to define neural circuits that convey information from the inner photoreceptors in the retina to the lobula complex in the Drosophila visual system. Elucidation of neural circuits and the mechanisms involved …
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Retrograde regulation of activity-dependent synaptic growth by Synaptotagmin 4
… and post-synaptic compartments during neuronal activity is a key mediator of neurotransmitter release and synaptic plasticity. Although the role of presynaptic Ca2+ in triggering vesicle fusion is established, molecular mechanisms that underlie responses to postsynaptic Ca2+ remain unknown. The …
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Characterization of CPG15 during cortical development and activity dependent plasticity
Regulation of gene transcription by neuronal activity is thought to be key to the translation of sensory experience into long-term changes in synaptic structure and function. Here we show that cgp15, a gene encoding an extracellular signaling molecule that promotes dendritic and axonal growth and …
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Mechanisms underlying rapid activity-dependent structural plasticity at Drosophila neuromuscular junctions
… of minutes in response to elevated neuronal activity. Using live imaging of synaptic growth, we characterized this dynamic process and demonstrate that rapid bouton budding requires retrograde BMP signaling and local alteration in the presynaptic actin cytoskeleton. BMP acts during …
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Transport activity dependent regulation of the yeast general amino acid permease
… regulation of Gap1p requires the catalytic activity of Gap1p, indicating that sorting and activity of Gap1p are controlled in cis. Gap1p therefore can serve as an amino acid sensor to control its activity in response to nutrient levels. This finding suggested that post-translational …
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Activity-dependent integration and plasticity of new neurons during postnatal neurogenesis
… can ultimately survive. However, what form of activity pattern determines the survival of new neurons remains unclear. Using NaChBac sodium channels to selectively alter the intrinsic excitability of new neurons in vivo, this manipulation reveals that neuronal survival critically depends on the …
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Analysis of activity-dependent morphological plasticity of dendritic spines on hippocampal neurons
… As recent experiments showed that synaptic activity and especially long-term potentiation (LTP) can modify spine morphology and number, I studied the effect of long-term depression (LTD) on these parameters. I used a local stimulation approach in combination with intracellular recordings and …
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Activity-dependent regulation of GIRK and Kv7 channels in homeostatic plasticity and epilepsy
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2022-11-15 without embargo terms
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Activity-dependent mitochondrial signaling drives GLR-1 dynamics and behavioral sensitization in C. elegans
… are beginning to unravel the effects of neuronal activity as well as subsequent calcium influx and its downstream signaling on synaptic AMPAR localization. However, how subcellular compartments, such as mitochondria, contribute to localized signaling, and how they affect AMPAR transport and …
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Impact of Second Messenger Modulation on Activity-Dependent and Basal Properties of Excitatory Synapses
… coded by the timing and the strength of neuronal activity, synaptic properties that translate neuronal activity into synaptic output profoundly determine the precision of information transfer. Synaptic properties are in turn shaped by changes in network activity to ensure appropriate synaptic …
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Role of BDNF secretion and signaling in the activity-dependent refinement of synaptic connections
… diverse types of plasticity, including the activity-dependent regulation of synaptic functions and refinement of synaptic connections. In addition, continuous generation of new neurons in the “adult” brain (adult neurogenesis) represents a powerful form of structural plasticity establishing …
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The study of Murine double minute-2 (Mdm2) in regulating neuronal activity-dependent protein translation
… and activation leads to the elevation of neural activity. Using a fragile X syndrome (FXS) mouse model, we demonstrated this phenomenon is modulated by FMRP-dependent Mdm2 down-regulation. This study provides a possible direction for rescuing the dysregulated Gp1 mGluR signaling observed in …
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Crimpy Sorts a BMP into the Regulated Secretory Pathway for Activity-Dependent Release in Drosophila Motorneurons
… is secreted from DCVs in response to synaptic activity. Indeed, by stimulating synaptic activity in motorneurons using two independent measures, high K+ depolarization and by activating the blue light-gated cation channel, channelrhodopsin, in motorneurons, we detect activity-dependent changes …
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When to learn and when to forget : NMDA normalization in hippocampal neurons-- activity-dependent, temporal and spatial properties.
… plasticity. We find that a complete blockade of activity succeeds in inducing only a transient enhancement of plasticity. A permanent enhancement of synaptic plasticity is achieved by selectively reducing the NMDA-R mediated Ca2+ flux associated with uncorrelated activity, via adjustment of the …
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The development of functional inputs to a neural circuit : synaptic strength before and after the activity-dependent maturation of the retinogeniculate system
Thesis (Ph.D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1999.
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