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Showing 1 to 6 of 6 for “"Activin B"”.
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Functional profiles of growth-related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle
… was performed to measure myostatin, follistatin, activin-B gene expressions during chicken embryonic development. Strong myostatin expression was found in the early chicken embryos (E 0, E 1) and the developmental expression pattern of myostatin mRNA coincided with the periods of primary and …
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The Roles of Activin A and B in Liver Inflammation and Fibrosis
… healing and promotes a pro-fibrogenic response. Activins are cytokines that have been identified as members of the TGFβ superfamily of growth and differentiation factors. Activin A and B, in particular, have been identified as having roles in the pathophysiology of liver disease, but have not …
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Exploration of novel activin A antibodies
… driven by distinct structural properties. Activin A is a TGF-β growth factor essential to development and healthy tissue function. Activin A signalling also contributes to the progression of many diseases, generating interest in therapeutic inhibition. Toward the goal of creating more …
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Developing Chemical Tools for the Inhibition of Activin A Signalling
Activin A is a member of the TGF-β superfamily, a family of structurally related growth factors that have been implicated in embryogenesis, homeostasis, and cancer. All members consist of pro- and mature domains which are post translationally cleaved. Upon signalling the pro-domain dissociates from …
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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… inflammation, and total energy homeostasis. Activin A and activin B play important roles in maintaining body composition and energy homeostasis. This dissertation highlights the role of activin/SMADs signaling in adipose tissue development, function, and maintenance.</p> <p>SMAD2/3 proteins …
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The role of beta-catenin in the development of fetal ovary and female germ cells
Ovarian development in mammals is considered as a default process, arising only in the absence of Sry, a testis-determining gene. However, current evidence has suggested the presence of an active pathway in fetal ovary. In particular, gene screening experiments have shown that many genes are …