Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 20 for “"Activin A"”.
-
Exploration of novel activin A antibodies
… driven by distinct structural properties. Activin A is a TGF-β growth factor essential to development and healthy tissue function. Activin A signalling also contributes to the progression of many diseases, generating interest in therapeutic inhibition. Toward the goal of creating more …
-
Developing Chemical Tools for the Inhibition of Activin A Signalling
Activin A is a member of the TGF-β superfamily, a family of structurally related growth factors that have been implicated in embryogenesis, homeostasis, and cancer. All members consist of pro- and mature domains which are post translationally cleaved. Upon signalling the pro-domain dissociates from …
-
The Roles of Activin A and B in Liver Inflammation and Fibrosis
… healing and promotes a pro-fibrogenic response. Activins are cytokines that have been identified as members of the TGFβ superfamily of growth and differentiation factors. Activin A and B, in particular, have been identified as having roles in the pathophysiology of liver disease, but have not …
-
The activin a pathway in fetal testis development and dysgenesis in the mouse
… hormone release from the pituitary, activin A can also function as a paracrine factor in many tissue contexts. As a member of the transforming growth factor β (TGFβ) superfamily, activin A can elicit changes in target cell proliferation, differentiation, and function via the SMAD …
-
The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
… peptides as chemical tools to investigate activin A signalling Activin A signalling has been implicated in a wide range of cancers as well as the orphan disease fibrodysplasia ossificans progressiva. In this section, stapled peptides were rationally designed with the intention of inhibiting …
-
Die Wirkung von Agrin auf die Genexpression isolierter Maus-Podozyten in Langzeitkultur
… c-Fos und den Wachstumsfaktor-Rezeptor Activin A Rezeptor, Typ 1 B nach Agrin-Stimulation zeigen. Ein Einfluss von Activin A und c-Fos auf die strenge Zellzykluskontrolle der Podozyten ist bisher nicht bekannt. Es wäre daher von großem Interesse die Rolle von Agrin und den …
-
Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm
… hESCs towards DE three different methods of activin A treatment were used. Single-cell gene expression analysis identified distinct gene expression signatures both between the activinA treated populations and within each population. Within the SOX17+ population, the DE markers CER1 and FOXA2 …
-
Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… inflammation, and total energy homeostasis. Activin A and activin B play important roles in maintaining body composition and energy homeostasis. This dissertation highlights the role of activin/SMADs signaling in adipose tissue development, function, and maintenance.</p> <p>SMAD2/3 proteins …
-
Roles of Heparan sulfate in mesendoderm differentiation of human embryonic stem cells
… revealed that HS ablation diminished FGF, Activin A and BMP signaling in differentiated cells. RNA-Seq revealed other biological processes affected by HS deficiency including neurogenesis, bone development and immune responses. Understanding the roles of HS in specific molecular mechanisms …
-
Untersuchungen zur Regulation der humanen Xylosyltransferase-I bei Fibrosen
… XT-I inhibitory molecules. This study revealed activin A, a cytokine of the transforming growth factor β (TGF-β) family, as a potent regulator of XYLT1 mRNA expression and XT activity in normal human dermal fibroblasts (NHDF). Using small molecule inhibitors and small interfering RNAs, the …
-
Altered cord blood biomarkers in neonatal brain injury
… those with abnormal outcomes at 2-years of age. Activin A and mACVR2B: Serum activin A analyses included 101 infants. No differences were observed across the groups (P = 0.693). The HIE group included 23 infants; a combination of mild and moderate HIE, without infants with a severe grade. No …
-
The Role of TGF-β in CTB-Insulin Regulated Human Dendritic Cell Tolerance
… of the immunoregulatory molecules TGF-β1, activin-A and integrin αvβ8 a molecule known to activate TGF-β1. In addition, CTB-INS stimulates increased levels of Smad2/3 phosphorylation in the vaccinated DCs. Further, we confirmed that CTB-INS upregulation of the TGF-β superfamily is unrelated …
-
Precision Medicine in Immunotherapy and Lung Cancer
… the role of immunohistochemistry markers for Activin-A, GDF-11 and TGF-B as potential predictive biomarkers for platinum-based chemotherapy within two populations – a retrospective cohort from Westmead Hospital and a prospectively-collected biobank (EnRICH) across New South Wales. The second …
-
Synthesis of Partially Saturated Bicyclic Heteroaromatics: sp3-Enriched Scaffolds for Drug Discovery
… has identified a weakly binding hit for Activin A.
-
Whole body metabolic alterations as an early event in Kras-Driven cancers
… of known cachexia factors, identifying IL-6 and Activin A as potential candidates that are elevated early in pancreatic cancer. We also conducted preliminary investigations into the mechanism governing tissue turnover in muscle in early disease and our results suggest autophagy may be the primary …
-
An in vitro model of human yolk sac and epiblast crosstalk
… of NODAL, WNT and JAK/STAT signalling via ACTIVIN-A, CHIRON, and leukaemia inhibitory factor (LIF) (ACL) induced an endodermal fate in human pluripotent stem cells (hPSCs). Functional and transcriptional analysis of ACL-treated cell populations revealed that the pluripotent state harboured …
-
Using human induced pluripotent stem cells to model cystinosis
… cells. In the first, iPS cells were treated with Activin A, the Wnt agonist CHIR99021 (CHIR) and BMPs and then purified by FACS, based on binding to the PT cell specific lectin FITC-conjugated lotus tetragonolobus lectin. The resulting PT-like cells expressed numerous PT markers, displayed an …
-
Role of the Activin/Follistatin system during angiogenesis and tumor progression
Activin A (AC) is a member of TGF-ß superfamily of growth factors that regulates cell proliferation, differentiation and apoptosis in many tissues. Follistatin (FS) is a functional antagonist of AC. The FS/AC system regulates endothelial cell (EC) proliferation. AC inhibits EC proliferation in an …
-
A quantitative proteomics study of the additive effect of inflammatory cytokines and injurious compression on cartilage damage
… as shown by increased levels of TGF-[beta] and activin A, and reduced levels of LTBP1. Also, biglycan and lumican, SLRPs known to be involved in early development are significantly increased, possibly indicating repair attempts. Other SLRPs such as PRELP and chondroadherin are also highly …
-
Synthesis of Structurally Diverse N-Substituted Quaternary Carbon Containing Small Molecules and Their Application as Novel Starting Points for Drug Discovery
… against three novel biological targets (CFI25, Activin A and Penicillin-binding protein 3). Utilising the modular nature of the synthetic route developed, derivatives of each hit were readily generated interrogating several synthetic exit vectors, including the N-substituted quaternary centre. …