Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 59 for “"Activin"”.
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Exploration of novel activin A antibodies
… driven by distinct structural properties. Activin A is a TGF-β growth factor essential to development and healthy tissue function. Activin A signalling also contributes to the progression of many diseases, generating interest in therapeutic inhibition. Toward the goal of creating more …
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Developing Chemical Tools for the Inhibition of Activin A Signalling
Activin A is a member of the TGF-β superfamily, a family of structurally related growth factors that have been implicated in embryogenesis, homeostasis, and cancer. All members consist of pro- and mature domains which are post translationally cleaved. Upon signalling the pro-domain dissociates from …
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Role of the Activin/Follistatin system during angiogenesis and tumor progression
Activin A (AC) is a member of TGF-ß superfamily of growth factors that regulates cell proliferation, differentiation and apoptosis in many tissues. Follistatin (FS) is a functional antagonist of AC. The FS/AC system regulates endothelial cell (EC) proliferation. AC inhibits EC proliferation in an …
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Activin signaling controls a wound-induced program essential for regenerative patterning
… it specifies head regeneration. We report that Activin signaling is required for regeneration polarity, and the underlying asymmetric activation of notum preferentially at anterior-facing wounds. We propose Activin signaling is involved in regeneration-specific responses broadly in the animal …
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Activin signaling promotes the competence of the prothoracic gland during Drosophila metamorphosis
… understood. Here we show that blocking Activin signaling in Drosophila prothoracic gland causes developmental arrest prior to metamorphosis. This defect is due to the absence of the ecdysone titer, a likely consequence of reduced expression of the ecdysone biosynthetic enzymes. We …
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The Roles of Activin A and B in Liver Inflammation and Fibrosis
… healing and promotes a pro-fibrogenic response. Activins are cytokines that have been identified as members of the TGFβ superfamily of growth and differentiation factors. Activin A and B, in particular, have been identified as having roles in the pathophysiology of liver disease, but have not …
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The activin a pathway in fetal testis development and dysgenesis in the mouse
… hormone release from the pituitary, activin A can also function as a paracrine factor in many tissue contexts. As a member of the transforming growth factor β (TGFβ) superfamily, activin A can elicit changes in target cell proliferation, differentiation, and function via the SMAD …
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Activin/Nodal Signalling Controls the Epigenome and Epitranscriptome of Human Pluripotent Stem Cells
… into the molecular mechanisms controlled by the Activin/Nodal-SMAD2/3 signalling pathway, whose activity dictates the balance between hPSC pluripotency and differentiation. First, I show that SMAD2/3 modulates the chromatin epigenetic landscape of hPSCs by cooperating with the pluripotency factor …
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Requirement of Baboon/dsmad2-Mediated Tgf-Beta/activin Signaling for Post-Mitotic Neuronal Development in the Drosophila Brain
… of widespread Baboon/dSmad2-mediated TGF-beta/Activin signaling in various neuronal developmental processes prior to the prepupal ecdysone peak. Interestingly, this stage-specific Babo/dSmad2 signaling appears to accelerate maturation and morphogenesis of post-mitotic neurons throughout the …
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The development of stapled peptides as chemical tools to investigate activin A signalling and as antibacterial agents targeting MsbA-mediated efflux
… peptides as chemical tools to investigate activin A signalling Activin A signalling has been implicated in a wide range of cancers as well as the orphan disease fibrodysplasia ossificans progressiva. In this section, stapled peptides were rationally designed with the intention of inhibiting …
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Role of SMAD2 and SMAD3 on Adipose Tissue Development and Function
… inflammation, and total energy homeostasis. Activin A and activin B play important roles in maintaining body composition and energy homeostasis. This dissertation highlights the role of activin/SMADs signaling in adipose tissue development, function, and maintenance.</p> <p>SMAD2/3 proteins …
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Multiple axes of inter-organ signaling regulate organ scaling
… size. In Drosophila, multiple ligands of the Activin-like subfamily (Myoglianin, Activin-β, and Dawdle) signal via the only type-I receptor Baboon (Babo). Similar to defects in insulin signaling, null mutants of babo result in small imaginal discs and small overall body size. This is in part …
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Cell Memory and Fate in Human Development
… of two key signaling pathways, namely Wnt and Activin/Nodal. From studies in model organisms both pathways are known to be required for initiating gastrulation and for the formation of mesoderm and endoderm, but it has been proposed that the level of Activin/Nodal signaling ultimately …
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Die Wirkung von Agrin auf die Genexpression isolierter Maus-Podozyten in Langzeitkultur
… c-Fos und den Wachstumsfaktor-Rezeptor Activin A Rezeptor, Typ 1 B nach Agrin-Stimulation zeigen. Ein Einfluss von Activin A und c-Fos auf die strenge Zellzykluskontrolle der Podozyten ist bisher nicht bekannt. Es wäre daher von großem Interesse die Rolle von Agrin und den …
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Functional profiles of growth-related genes during embryogenesis and postnatal development of chicken and mouse skeletal muscle
… was performed to measure myostatin, follistatin, activin-B gene expressions during chicken embryonic development. Strong myostatin expression was found in the early chicken embryos (E 0, E 1) and the developmental expression pattern of myostatin mRNA coincided with the periods of primary and …
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The Role of Snail Homolog 1 in Embryonic Stem Cell Differentiation
… cell: EpiSC) stage. Consistent with a role for Activin in EpiSC maintenance, we show that miR-200 requires Activin to efficiently maintain cells at the epiblast stage. Together, these findings demonstrate that Snail and miR-200 act in opposition to regulate EMT and exit from the EpiSC stage …
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Genetic and gene expression analysis of nasopharyngeal carcinoma (NPC)
… that the C666-1 cell line is intact in the activin and Hh signalling pathways but not in the TGF-β pathway. However, the C666-1 cells appear to resist activin-mediated cell growth inhibition
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The Role and Control of WNT Signalling in an HESC Model of Human Primitive Streak
… (PS) and is largely controlled by WNT, BMP, and ACTIVIN/NODAL signalling. Despite detailed characterization in model organisms, the human PS and the role these pathways play in its formation and patterning remains a mystery. In this work I focused on understanding the role and control of the WNT …
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Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm
… hESCs towards DE three different methods of activin A treatment were used. Single-cell gene expression analysis identified distinct gene expression signatures both between the activinA treated populations and within each population. Within the SOX17+ population, the DE markers CER1 and FOXA2 …
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