Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 40 for “"Active zone"”.
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Regulation of Kinesin-3 activity by active zone protein SYD-2
Diese Arbeit fokussiert sich auf die Charakterisierung des Effekts der SYD-2/Kinesin Interaktion auf die Motilität und mechanochemische Eigenschaften des UNC-104 Motors.In vitro können die Motilitätseigenschaften von molekularen Motoren am besten mittels rekombinant exprimierten Motoren, welche an …
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"Bruchpilot" -molecular and functional characterization of a novel active zone protein at the Drosophila synapse
… membrane structures at the synapse known as the active zones. These are highly ordered electron dense grids and are composed of several proteins which assist the synaptic vesicles in relocating in the vicinity of Ca2+ channels thereby increasing their fusion probability and then bringing about …
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The interaction of ELKS with Ca2+ channel β subunits may contribute to active zone organization
The cytoskeletal matrix of the active zone (CAZ) and synaptic voltage-dependent calcium channels (VDCCs) are both required for the organization and regulation of synaptic vesicle release. Here we report a novel interaction between the CAZ protein family ELKS and VDCC β subunits. We found that two …
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The Role of Presynaptic Par-1 Kinase in Regulating the Localization of Active Zone Protein BRP
… diseases. Since proteins that reside at the active zones are used most frequently during synaptic transmission, they must be continuously replenished to maintain active zones. Therefore, the trafficking of these proteins plays an essential role in replenishing these vital components necessary …
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Deciphering molecular interactions in presynaptic dense projection formation in C. elegans
… distinct set of proteins at a site known as the active zone, which dictates the location and timing of neurotransmitter release. These active zone functions are thought to revolve around a central protein scaffold, which is visible under electron microscopy as a structure known as the dense …
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Magnetohydrodynamics in the Inner Regions of Protoplanetary Discs
… discs, which encompass the putative habitable zone, comprise a highly ionised, turbulent active region and a poorly ionised outer dead zone. The complex magnetohydrodynamic processes at this dead–active zone interface significantly impact the disc's evolution – influencing global magnetic flux …
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Precision and reliability of cochlear nerve response in mice lacking functional synaptic ribbons
… in which ribbons are no longer anchored to the active zone. Since each mammalian AN fiber usually receives input from a single inner hair cell active zone to which a single ribbon is typically anchored, single-fiber recordings from bassoon mutants and control mice offer a sensitive functional …
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Modeling and design of semi-solid flow batteries
… intermittent flow operation. The importance of active material selection, and its impact on efficient stoichiometric flow operation is discussed. Electrochemically active zone considerations relevant to intermittent flow operation of semi-solid flow batteries (or other potential electronically …
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Investigating the molecular environments and interactions of pathological TDP-43 filaments
Filamentous transactive response DNA-binding protein 43 (TDP-43) pathology characterises many neurodegenerative diseases, including amyotrophic lateral sclerosis (ALS) and frontotemporal dementias (FTD). Pathogenic mutations in TARDBP, the gene encoding TDP-43, can cause ALS and FTLD by increasing …
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MOLECULAR MECHANISMS OF APPETITE AND ENERGY BALANCE
… We sought to address this by deleting active zone protein, ELKS1 and ELKS2, through Nkx2.1-cre-loxP recombination. Nkx2.1 is a developmental progenitor of hypothalamic nuclei; while the loss of ELKS proteins has been shown to reduce neurotransmitter release at both inhibitory and …
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Analysis of Cancer Margins in Mass Spectrometry Images
… that the tumor stroma was a biologically active zone that extended past the pathologically annotated boundary in every sample.
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Investigation of microbial metal-sulfide interfacial environments under mineral bioleach simulated conditions
… the microbial-mineral-EPS interface the dominant active zone in terms of microbial oxidation and mineral dissolution. There is a limited understanding of microbial biofilm formation within a bioleach heap. The implication of various microorganisms having a set of defined or optimal conditions …
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Laxity of the Hip Capsule in Natural and Posteriorly Implanted Specimens
… resistive torque rotation space exhibits an 'active zone' whereby the resistive torque attempts to restore it back to the 'neutral zone' where the resistive torque is minimized. Large differences in capsular laxity between natural and implanted specimens were observed, particularly with an …
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NOVEL SENSOR PLATFORMS BASED ON FABRY-PEROT RESONATORS FOR APPLICATIONS IN ENVIRONMENTAL GEOPHYSICS
… in soil by changing the functional films in the active zone of the sensor"--Abstract, p. iv</p>
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Regulation of synaptic function and plasticity by cyclin-dependent kinase 5
… of the N-type calcium channel with the active zone protein RIM1, which impacted vesicle docking and neurotransmission. Finally, we identified the postsynaptic density protein Shank3 as a Cdk5 substrate and observed that Cdk5-mediated phosphorylation of Shank3 plays a critical role in …
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Functional changes in connectivity induced by differential manipulations of activity in Drosophila tonic versus phasic motoneurons
… Decreased Ib activity resulted in reduced active zone (AZ) number and decreased postsynaptic subsynaptic reticulum (SSR) volume, with the emergence of filopodial-like protrusions from synaptic boutons of the Ib input. Decreased Is activity did not induce structural changes at its own …
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… interact with components of the presynaptic active zone and which may contribute to presynaptic assembly downstream of synaptic cell surface receptors.
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Transfer Properties of the Hair Cell-Afferent Fiber Synapse
… the operation of the hair cell's presynaptic active zone is key to understanding auditory transduction. However, the lack of suitable experimental systems in which to investigate both the presynaptic and postsynaptic aspects of this synapse with high resolution has limited our understanding of …
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Coalbed gas origin and distribution in the southeastern Illinois Basin
… volatile bituminous A) coals in a tectonically active zone in the western Kentucky part of the basin contain gases of distinctly thermogenic origin. Enrichment experiments and phylogeny of the microbial community responsible for generation of coalbed methane in the Indiana part of the Illinois …
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Axon Development and Synapse Formation in Olfactory Sensory Neurons
… The olfactory epithelium is therefore an attractive model for the study of axonal growth and synapse formation. The present set of studies attempts to provide insights into synapse formation and axonal development of olfactory sensory neurons. First, I sought to understand the regulation of …
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