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Showing 1 to 20 of 87 for “"Active pharmaceutical ingredients"”.
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NOVEL SYNTHETIC PROCESSES FOR THE INDUSTRIAL PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS
… for the industrial preparation of two emerging active pharmaceutical ingredients (API). Specifically, the process for the preparation of a new paclitaxel prodrug, namely octadecanedioc acid-paclitaxel, was defined. This paclitaxel derivate has shown better results in vivo trials, against a wide …
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Microfluidic platforms for screening of crystallization conditions of active pharmaceutical ingredients
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2012-05-19T10:00:13Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Dissertations and Theses - Chemical and Biomolecular Engineering (ID: 591) No. of bitstreams: 4 Thorson_Michael.pdf: 901648 bytes, …
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Crystallization of active pharmaceutical ingredients using microfluidic platforms and meniscus-guided coating
… times and large development cost has led the pharmaceutical industry to evaluate and improve pharmaceutical development and manufacturing procedures. Emphasis has been placed on the connection between drug development and discovery, especially on characterization of candidate drugs earlier in …
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Optimal handling of Highly Active Pharmaceutical Ingredients during milling and blending operations
… thesis investigates best practices for Highly Active Pharmaceutical Ingredient (HAPI) milling and blending. We utilize a qualitative analysis centering on a benchmarking study and quantitative analyses using a probabilistic capacity simulation and tradeoff methodology. The analyses indicate …
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Engineering of Amorphous Active Pharmaceutical Ingredients by Sonoprecipitation and Spray Drying Pre-and Post-Processing Pharmaceutical Characterisation. Pre- and Post-Processing Physicochemical and Micromeritic Characterisation of Active Pharmaceutical Ingredients
Amorphous active pharmaceutical ingredients remain in the research focus as an avenue to achieve a better solubility of drugs. Several processing techniques are applied to produce amorphous materials. Main two approaches applied to production of amorphous phases are comminution of crystalline …
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CONTINUOUS-FLOW STRATEGIES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS AND RELEVANT INTERMEDIATES
… continuous-flow strategies for the synthesis of active pharmaceutical ingredients (APIs) and key intermediates, with the aim of improving reaction efficiency, safety, and scalability. The work focuses on the integration of modern synthetic methodologies with enabling technologies such as flow …
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Heterogeneous nucleation of active pharmaceutical ingredients on polymers : applications in continuous pharmaceutical manufacturing
… nucleation and crystal growth in the absence of active mass transfer would have too small a throughput and too large a footprint to be useful. The main reasons were long average nucleation induction times and slow crystal growth in the absence of convection. A set of batch desupersaturation …
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Study of controlled release of active pharmaceutical ingredients from functionalized nanoclays and polymer matrices
… structure-property-processing relationships of pharmaceutical polymer-based products. They are: a) modification of a pharmaceutical anionic nanoclay with two different Active Pharmaceutical Ingredients (APIs) to produce nanohybrid API carriers intended to be used alone or in acrylic polymer …
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Physicochemical and computational approaches for the prediction of the manufacturability of active pharmaceutical ingredients
Tablets have aided the delivery of active pharmaceutical ingredients (APIs) to patients since the 1800s, however tablet failure, such as punch sticking and tablet hardness issues, during manufacturing is still common. The techniques currently available for the prediction of manufacturability of …
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Preformulation solid-state supramolecular beneficiation of selected active pharmaceutical ingredients and a novel drug candidate
… selected compounds for use in the formulation of pharmaceutical products. The compounds selected were: Clevudine, an established drug that is currently in use for the treatment of chronic hepatitis B infections, 6-(3- (Methylsulfonyl)phenyl)-3-(4-(methylsulfonyl)phenyl)-imidazo[1,2-b]pyridazine …
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Developing strategies and equipment for continuous isolation of active pharmaceutical ingredients (APIs) by filtration, washing and drying
In pharmaceutical sector, compounds forming the drug and especially the activep harmaceutical ingredients (API's) are required to be pure, in accordance with the regulatory authorities' rules. The isolation stage is used to remove the impure liquid phase and to remove surface impurities from the …
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Modeling, optimization, and sensitivity analysis of a continuous multi-segment crystallizer for production of active pharmaceutical ingredients
… a new type of crystallizer for the production of pharmaceuticals. The multi-segment, multi-addition plug-flow crystallizer (MSMA-PFC) offers better control over supersaturation in one dimension compared to a batch or stirred-tank crystallizer. Through use of a population balance framework, we have …
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Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression
… to increase surface area of poorly soluble Active Pharmaceutical Ingredient’s (API). This size reduction improves the dissolution rate and permeability thereby increasing the bioavailability for hydrophobic API’s.</p> <p>Tablets and capsules are the most marketed and easy to manufacture …
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The sorption fate of active pharmaceutical ingredients in soils receiving high wastewater inputs and implications for risk assessments
… access to medicines have led to an increase in active pharmaceutical ingredients (APIs) entering sewerage networks. Wastewater in lower and lower middle-income countries use that use wastewater for irrigation may use untreated or poorly treated wastewater resulting in the potential for greater …
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Design of a rapid, continuous, small-scale device for creating dry powders from concentrated suspensions containing active pharmaceutical ingredients
Current methods of producing pharmaceutical compounds are large batch processes. The minimum time-to-patient for drug manufacturing is approximately 100 days. Using a continuous manufacturing process, the time-to-patient could be reduced to less than ten days. The scope of this paper encompasses …
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NOVEL SUSTAINABLE STRATEGIES FOR THE SYNTHESIS OF ACTIVE PHARMACEUTICAL INGREDIENTS (APIS) AND BIOACTIVE MOLECULES THROUGH THE EXPLOITATION OF ISOLATED ENZYMES AS BIOCATALYSTS
… on the development of sustainable entries to bioactive compounds, small molecules, and chiral synthons of pharmaceutical and industrial interest, by combining the ability of various biocatalysts alongside traditional organic synthetic protocols. Both commercially available and in-house expressed, …
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Co-crystal screening of poorly water-soluble active pharmaceutical ingredients. Application of hot stage microscopy on curcumin-nicotinamide system and construction of ternary phase diagram of fenbufen-nicotinamide-water co-crystal system.
… motivated by the fact that a number of active pharmaceutical ingredient (API) co-crystals with improved dissolution have recently been synthesized. Hence, co-crystallization technique highlights an alternative means to improve the performance of curcumin. Within our work evidences for a …
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The Physical Chemistry of pMDI Formulations Derived from Hydrofluoroalkane Propellants. A Study of the Physical Behaviour of Poorly Soluble Active Pharmaceutical Ingredients; Bespoke Analytical Method Development Leading to Novel Formulation Approaches for Product Development.
Active Pharmaceutical Ingredients (APIs) are frequently prepared for delivery to the lung for local topical treatment of diseases such as Chronic Obstructive Pulmonary Disease (COPD) and asthma, or for systemic delivery. One of the most commonly used devices for this purpose is the pressurised …
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Assessment of a marine polysaccharide for use as excipient in pharmaceutical hot-melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is currently investigated by both industry and academia as a method for manufacturing solid oral dosages with improved bioavailability of poorly-water soluble active pharmaceutical ingredients (APIs) and control drug release of water-soluble APIs. Although …
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