Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 71 for “"Active pharmaceutical ingredient"”.
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Inventory modeling for active pharmaceutical ingredient supply chains
Pharmaceutical companies traditionally manufactured drugs in-house, and have only recently been increasingly outsourcing production to contract manufacturing organizations (CMOs). In this work, we use inventory modeling to explore the trade-off between the attractive purchase price and the hidden …
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Hot-melt mixing of partially miscible active pharmaceutical ingredient-polymer mixtures
Solid dispersion/solution processes for producing pharmaceutical oral dosages such as hot-met extrusion (HME) have received increasing attention by industry and academe because they can enhance drugs' solubility and even bioavailability to a great extent by converting drugs from crystalline to …
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Improvement of cleaning effectiveness through Statistical Process Control in active pharmaceutical ingredient (API) manufacturing
… the effectiveness of cleaning processes at an active pharmaceutical ingredient (API) manufacturing site that was in the phase of engineering trials and cleaning cycle development. Cleaning cycles executed on the site prior to the project were found to be inconsistent in cleaning the equipment …
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Tactical planning optimization for campaign scheduling of active pharmaceutical ingredient production based on monoclonal antibodies
… are the fastest growing segment in the biopharmaceutical industry. They are used today as therapeutics and diagnostics for several medical applications, including various types of cancer, rheumatoid arthritis, psoriasis, severe asthma macular degeneration, multiple sclerosis and more. In …
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Impact of Polymers on the Solution Crystal Growth Rate of a Poorly Water-Soluble Active Pharmaceutical Ingredient
… impediment to the oral delivery of over 75% of pharmaceutical compounds currently under development. The bioavailability of these compounds can be enhanced with the use of supersaturating dosage forms, due to their high flux rates across the gastrointestinal tract membrane. However, the success …
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Crystal engineering, Bio Pharmaceutics and Cell biology of active pharmaceutical ingredient (drug) nanoparticles. Formation and cell interaction of hydrocortisone and prednisolone nanoparticles.
… that it can be used as an enabling technology by pharmaceutical researchers and industry to overcome issues associated with the low bioavailability of hydrophobic drugs. In the first part of the current study, nanosuspensions of two of hydrophobic steroid drugs: hydrocortisone and prednisolone …
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Experimental Modeling of Twin-Screw Extrusion Processes to Predict Properties of Extruded Composites
… properties of the composite. In addition, the pharmaceutical properties resulting from the compounding of an active pharmaceutical ingredient are modeled as a function of the operating conditions, indicating the physical behavior inducing the property responses.
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Methods for Increasing Sensitivity and Throughput of Solid-State NMR Spectroscopy of Pharmaceutical Solids
… structure, and dynamics of a pure or formulated active pharmaceutical ingredient (API). To overcome the major shortcomings of SSNMR, acquisition time and sensitivity, a two-sample probe was designed, developed, and tested. The probe allowed for two samples to be acquired simultaneously while …
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Dispersion and dissolution kinetics of API particles in pharmaceutical hot melt extrusion
Pharmaceutical Hot Melt Extrusion (HME) is essentially a special case of polymer compounding. The elementary steps involved in traditional plastics melt processing are handling of particulates, melting, dispersive and distributive mixing, devolatilization and stripping, and finally pressurization …
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Enantioselective synthesis of pretomanid & investigations of Raman spectroscopy for through-tube monitoring of reactions
… Pretomanid is a potential cornerstone active pharmaceutical ingredient for the treatment of tuberculosis (TB). It is found in several advanced clinical trials and can possibly treat all forms of TB. In this report, we discuss the development of a novel synthesis of pretomanid through a …
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The development and application of online modelling methods
… technology, the NIR spectral analysis of pharmaceutical tablets. The NIR spectra of over 250 tablets were collected over three production campaigns from 1997 to 1999. Accompanying the NIR spectral data were the chemical and physical tablet parameters, active pharmaceutical ingredient, …
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Effects of API particle size on the dissolution rate in molten polymer excipient matrices during hot melt extrusion, conducted in a co-rotating twin-screw extruder
The effect of the Active Pharmaceutical Ingredient (API) particle size on the dissolution rate in the polymer excipient during hot melt extrusion is investigated using a co-rotating twin-screw extruder with three different screw configurations. Acetaminophen (APAP) and amphiphilic polyvinyl …
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Theoretical and experimental investigation of particle interactions in pharmaceutical powder blending
In pharmaceutical manufacturing practices, blending of active pharmaceutical ingredient (API) with excipients is a crucial step in that homogeneity of active ingredient after blending is a key issue for the quality assurance of final products. Inadequate knowledge of the interdependence between raw …
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Optimal handling of Highly Active Pharmaceutical Ingredients during milling and blending operations
… thesis investigates best practices for Highly Active Pharmaceutical Ingredient (HAPI) milling and blending. We utilize a qualitative analysis centering on a benchmarking study and quantitative analyses using a probabilistic capacity simulation and tradeoff methodology. The analyses indicate …
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Preparation of nanovehicles for targeted drug delivery
Application of nanotechnology in pharmaceutical research has opened new frontiers for drug development and its efficient delivery. In recent years, the focus of the research has been on the engineering of nano/micro-particulate structures for efficient and targeted delivery of drugs for selective …
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Co-crystal screening of poorly water-soluble active pharmaceutical ingredients. Application of hot stage microscopy on curcumin-nicotinamide system and construction of ternary phase diagram of fenbufen-nicotinamide-water co-crystal system.
… motivated by the fact that a number of active pharmaceutical ingredient (API) co-crystals with improved dissolution have recently been synthesized. Hence, co-crystallization technique highlights an alternative means to improve the performance of curcumin. Within our work evidences for a …
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Design of a small-scale continuous linear motion pharmaceutical filtration module
A new small-scale continuous linear motion pharmaceutical filtration prototype was designed, fabricated, and tested. The goal of this unit is to filter an Active Pharmaceutical Ingredient (API) from a mixture of API molecules, ethyl acetate, and possible contaminants. This unit is important in the …
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An investigation of the potential for and application of life cycle analysis in the pharmaceutical industry
… have been made to apply this method to the pharmaceutical industry. The Toxic Release Inventory is a powerful tool to determine areas of high potential for emissions reductions in industry. When applied to the pharmaceutical industry and coupled with a life cycle assessment, areas for …
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A Quantitative Study of Drug Recrystallization in Drug-In-Adhesive Transdermal Patches Using Vibrational Spectroscopy
… recrystallization. Recrystallization of the active pharmaceutical ingredient can adversely affect the efficacy of transdermal products. This dissertation demonstrates a systematic approach to quantify the crystalline content of the API in DIA systems. This approach uses a novel method of …
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Development of Multivariate Powder X-ray Diffraction Techniques and Total Scattering Analyses to Enable Informatic Calibration of Solid Dispersion Potential
… exists that defines the propensity of an active pharmaceutical ingredient to form a binary amorphous molecular solid dispersion with polyvinylpyrrolidone:vinyl acetate copolymer using a melt-quench procedure. Testing this hypothesis required execution of specific aims directed to address …
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