Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"Active Zones"”.
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Regulation of Presynaptic Ca²⁺ Channel Abundance at Active Zones Through a Balance of Delivery and Turnover
… release at specialized presynaptic sites termed active zones (AZs). The abundance of VGCCs at AZs regulates neurotransmitter release probability (Pᵣ), a key presynaptic determinant of synaptic strength. Although biosynthesis, delivery and recycling cooperate to establish AZ VGCC abundance, …
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The Role of Presynaptic Par-1 Kinase in Regulating the Localization of Active Zone Protein BRP
… diseases. Since proteins that reside at the active zones are used most frequently during synaptic transmission, they must be continuously replenished to maintain active zones. Therefore, the trafficking of these proteins plays an essential role in replenishing these vital components necessary …
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The Functional Organization of Synaptic Vesicle Pools In A Retinal Bipolar Neuron
… entry and vesicle fusion, forming ribbon-style active zones. The ability of ribbon synapses to maintain rapid and sustained neurotransmission is critical for vision, hearing and balance. At retinal ribbon synapses, three vesicle pools have been proposed. A rapid pool of vesicles that are docked …
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"Bruchpilot" -molecular and functional characterization of a novel active zone protein at the Drosophila synapse
… membrane structures at the synapse known as the active zones. These are highly ordered electron dense grids and are composed of several proteins which assist the synaptic vesicles in relocating in the vicinity of Ca2+ channels thereby increasing their fusion probability and then bringing about …
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Transfer Properties of the Hair Cell-Afferent Fiber Synapse
… the operation of the hair cell's presynaptic active zone is key to understanding auditory transduction. However, the lack of suitable experimental systems in which to investigate both the presynaptic and postsynaptic aspects of this synapse with high resolution has limited our understanding of …
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Regulation of synaptic structure and function at the Drosophila neuromuscular junction
… disrupts synaptic morphology and presynaptic active zone organization. Actin 57B is one of six actin genes in Drosophila and is expressed in body wall muscle during larval development. The isolated allele harbors a point mutation disrupting a highly conserved amino acid present throughout the …
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Geophysical Investigation of the Yellowstone Hydrothermal System
… yet little is known about the hydrothermally active zones hundreds of meters beneath the features. Transient electromagnetic (TEM) soundings and 2D direct current (DC) resistivity profiles show that hydrothermal alteration at active sites have a higher electrical conductivity than the …
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TOD in the context of Cape Town: a case study of Bellville
… Central Area which includes: development zones (Intensification zones, active zones and transition zones), pro-active planning and streamlined development applications, transport management tools such as a parking management system and pricing strategy, as well as informal street trading, …
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Investigating neuronal mitochondrial DNA loss in Drosophila melanogaster
… of mitochondria and the number of pre-synaptic active zones (the sites of neurotransmitter release) in motor neurons with reduced mtDNA content. Taken together these data show that neuronal mtDNA loss results in defects in synaptic development and reduced motor neuron function. We further show …
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Dissecting Roles for the Macromolecular Machinery Involved in Neurotransmitter Release
… involves synaptic vesicle docking at presynaptic active zones, priming of the vesicles to a release-ready state, and calcium evoked fusion of the vesicle and plasma membranes. The probability of release is modulated by plastic changes that depend on synaptic activity; these changes shape the …
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Partitioning Uncertainty for Non-Ergodic Probabilistic Seismic Hazard Analyses
… instrumental networks operating in seismically active zones so that a sufficient number of recordings are made. Only recently, with the advent of networks such as the Japanese KiK-net network has this become possible. This study contributes to the state of the art in earthquake engineering and …
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Mechanisms Of Presynaptic CaV2 Calcium Channel Localization In Caenorhabditis Elegans
… GFP-tagged UNC-2 is localized to presynaptic active zones of sensory and motor neurons. Using this system, I conducted a direct visual genetic screen for mutants that are defective in UNC-2 localization, identifying three genes, calf-1, unc-36 and pqn-53/calf-2. CALF-1 is a neuronal-specific …
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Drosophila melanogaster Genetic Model of Parkinson’s Disease: phytotherapy approach for a new and more sustainable pre-clinical investigation
… protein expression, mitochondria and synaptic active zone morphology; both in treated and untreated flies. The overall results indicate that Mpe shows a significant effect on PINK1B9 mutants while Wse acts mostly on LRRK2WD40 ones. The two phytochemical extracts tested were able to counteract …
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Advanced analysis of complex seismic waveforms to characterize the subsurface Earth structure
… necessary for urban areas located in seismic active zones. SPAC analysis of microtremors provides an efficient way to estimate Vs structure. Compared with other Vs estimating methods, SPAC is noninvasive and does not require any active sources, and therefore, it is especially useful in big …
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The glutamate hypothesis of depression: the effect of stress and glucocorticoids on glutamate synapse and the action of antidepressants
… and in vesicles docking, fusion and recycling at active zones. We found that both FS-stress and CORT induce an increase of synapsin I phosphorylation in synaptic membranes selectively at site 1. The preincubation with both RU486 and spironolactone, prevented the CORT-induced synapsin I …
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A role for the SHANK1 scaffold protein in experience-induced synaptic plasticity and memory consolidation
… in the binding of glutamate receptors to their active zones. Previous developmental studies have demonstrated that SHANK1 is initially localized in the cytoplasm of neurons followed by an increased dendritic spine expression during periods of postnatal dendritic spine proliferation. Likewise, …
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Dreidimensionale Rekonstruktion einer exzitatorischen zentralen Synapse : die Held`sche Calyx - Prinzipalneuron Synapse im medialen Nucleus des Trapezkörpers
Ziel der vorliegenden Arbeit war die computergestützte 3-D-Rekonstruktion einer Held´schen Calyx - Prinzipalneuron Synapse im medialen Nucleus des Trapezkörpers (MNTB) aus seriellen Ultradünnschnitten einer postnatal Tag 9 alten Ratte. <br>Der Calyx ist eine sehr große (ca. 20-25 µm im Durchmesser) …
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Stress tensor estimates derived from focal mechanism solutions of sparse data sets: applications to seismic zones in Virginia and eastern Tennessee
… principal stress orientations for seismically active zones in the Southeastern United States, using focal mechanism solution sets derived by the program FOCMEC. Eight events were studied for the Giles County Seismic Zone, 13 for the Central Virginia Seismic Zone, and 11 for the Eastern …
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The dynamic soil structure interaction of shallow foundations on dry sand beds
… of shallow foundations located in seismically active zones typically takes a near zero tolerance approach to allowing relative movements between the foundation and underlying soil. This results in a rigid coupling of the foundation with the soil and hence the full transmission of the seismic …