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Showing 1 to 20 of 161 for “"Active Pharmaceutical"”.
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Inventory modeling for active pharmaceutical ingredient supply chains
Pharmaceutical companies traditionally manufactured drugs in-house, and have only recently been increasingly outsourcing production to contract manufacturing organizations (CMOs). In this work, we use inventory modeling to explore the trade-off between the attractive purchase price and the hidden …
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NOVEL SYNTHETIC PROCESSES FOR THE INDUSTRIAL PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS
… for the industrial preparation of two emerging active pharmaceutical ingredients (API). Specifically, the process for the preparation of a new paclitaxel prodrug, namely octadecanedioc acid-paclitaxel, was defined. This paclitaxel derivate has shown better results in vivo trials, against a wide …
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Hot-melt mixing of partially miscible active pharmaceutical ingredient-polymer mixtures
Solid dispersion/solution processes for producing pharmaceutical oral dosages such as hot-met extrusion (HME) have received increasing attention by industry and academe because they can enhance drugs' solubility and even bioavailability to a great extent by converting drugs from crystalline to …
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Microfluidic platforms for screening of crystallization conditions of active pharmaceutical ingredients
Item reinstated by Sarah Shreeves (sshreeve@illinois.edu) on 2012-05-19T10:00:13Z Item was in collections: University of Illinois Dissertations and Theses (ID: 204) Dissertations and Theses - Chemical and Biomolecular Engineering (ID: 591) No. of bitstreams: 4 Thorson_Michael.pdf: 901648 bytes, …
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Crystallization of active pharmaceutical ingredients using microfluidic platforms and meniscus-guided coating
… times and large development cost has led the pharmaceutical industry to evaluate and improve pharmaceutical development and manufacturing procedures. Emphasis has been placed on the connection between drug development and discovery, especially on characterization of candidate drugs earlier in …
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Optimal handling of Highly Active Pharmaceutical Ingredients during milling and blending operations
… thesis investigates best practices for Highly Active Pharmaceutical Ingredient (HAPI) milling and blending. We utilize a qualitative analysis centering on a benchmarking study and quantitative analyses using a probabilistic capacity simulation and tradeoff methodology. The analyses indicate …
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Engineering of Amorphous Active Pharmaceutical Ingredients by Sonoprecipitation and Spray Drying Pre-and Post-Processing Pharmaceutical Characterisation. Pre- and Post-Processing Physicochemical and Micromeritic Characterisation of Active Pharmaceutical Ingredients
Amorphous active pharmaceutical ingredients remain in the research focus as an avenue to achieve a better solubility of drugs. Several processing techniques are applied to produce amorphous materials. Main two approaches applied to production of amorphous phases are comminution of crystalline …
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CONTINUOUS-FLOW STRATEGIES FOR THE PREPARATION OF ACTIVE PHARMACEUTICAL INGREDIENTS AND RELEVANT INTERMEDIATES
… continuous-flow strategies for the synthesis of active pharmaceutical ingredients (APIs) and key intermediates, with the aim of improving reaction efficiency, safety, and scalability. The work focuses on the integration of modern synthetic methodologies with enabling technologies such as flow …
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Heterogeneous nucleation of active pharmaceutical ingredients on polymers : applications in continuous pharmaceutical manufacturing
… nucleation and crystal growth in the absence of active mass transfer would have too small a throughput and too large a footprint to be useful. The main reasons were long average nucleation induction times and slow crystal growth in the absence of convection. A set of batch desupersaturation …
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Study of controlled release of active pharmaceutical ingredients from functionalized nanoclays and polymer matrices
… structure-property-processing relationships of pharmaceutical polymer-based products. They are: a) modification of a pharmaceutical anionic nanoclay with two different Active Pharmaceutical Ingredients (APIs) to produce nanohybrid API carriers intended to be used alone or in acrylic polymer …
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Physicochemical and computational approaches for the prediction of the manufacturability of active pharmaceutical ingredients
Tablets have aided the delivery of active pharmaceutical ingredients (APIs) to patients since the 1800s, however tablet failure, such as punch sticking and tablet hardness issues, during manufacturing is still common. The techniques currently available for the prediction of manufacturability of …
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Improvement of cleaning effectiveness through Statistical Process Control in active pharmaceutical ingredient (API) manufacturing
… the effectiveness of cleaning processes at an active pharmaceutical ingredient (API) manufacturing site that was in the phase of engineering trials and cleaning cycle development. Cleaning cycles executed on the site prior to the project were found to be inconsistent in cleaning the equipment …
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Preformulation solid-state supramolecular beneficiation of selected active pharmaceutical ingredients and a novel drug candidate
… selected compounds for use in the formulation of pharmaceutical products. The compounds selected were: Clevudine, an established drug that is currently in use for the treatment of chronic hepatitis B infections, 6-(3- (Methylsulfonyl)phenyl)-3-(4-(methylsulfonyl)phenyl)-imidazo[1,2-b]pyridazine …
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Tactical planning optimization for campaign scheduling of active pharmaceutical ingredient production based on monoclonal antibodies
… are the fastest growing segment in the biopharmaceutical industry. They are used today as therapeutics and diagnostics for several medical applications, including various types of cancer, rheumatoid arthritis, psoriasis, severe asthma macular degeneration, multiple sclerosis and more. In …
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Developing strategies and equipment for continuous isolation of active pharmaceutical ingredients (APIs) by filtration, washing and drying
In pharmaceutical sector, compounds forming the drug and especially the activep harmaceutical ingredients (API's) are required to be pure, in accordance with the regulatory authorities' rules. The isolation stage is used to remove the impure liquid phase and to remove surface impurities from the …
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Impact of Polymers on the Solution Crystal Growth Rate of a Poorly Water-Soluble Active Pharmaceutical Ingredient
… impediment to the oral delivery of over 75% of pharmaceutical compounds currently under development. The bioavailability of these compounds can be enhanced with the use of supersaturating dosage forms, due to their high flux rates across the gastrointestinal tract membrane. However, the success …
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Modeling, optimization, and sensitivity analysis of a continuous multi-segment crystallizer for production of active pharmaceutical ingredients
… a new type of crystallizer for the production of pharmaceuticals. The multi-segment, multi-addition plug-flow crystallizer (MSMA-PFC) offers better control over supersaturation in one dimension compared to a batch or stirred-tank crystallizer. Through use of a population balance framework, we have …
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Effect of Compression Force on Agglomeration of Micronized Active Pharmaceutical Ingredients: Techniques to Prevent API Agglomeration During Compression
… to increase surface area of poorly soluble Active Pharmaceutical Ingredient’s (API). This size reduction improves the dissolution rate and permeability thereby increasing the bioavailability for hydrophobic API’s.</p> <p>Tablets and capsules are the most marketed and easy to manufacture …
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The sorption fate of active pharmaceutical ingredients in soils receiving high wastewater inputs and implications for risk assessments
… access to medicines have led to an increase in active pharmaceutical ingredients (APIs) entering sewerage networks. Wastewater in lower and lower middle-income countries use that use wastewater for irrigation may use untreated or poorly treated wastewater resulting in the potential for greater …
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