Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 16 of 16 for “"Activator Protein-1"”.
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
… becomes highly upregulated is SPARC (secreted protein acidic and rich in cysteine). Increased SPARC expression is associated with malignant progression in a variety of different cancers, although little is known regarding the mechanisms of SPARC gene regulation. Therefore, the objectives of …
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Adenylyl Cyclase 2 Selectively Regulates IL-6 Expression in Human Bronchial Smooth Muscle Cells
… cellular localization, regulation, and protein interactions, and most cells express multiple isoforms. We hypothesized that cAMP produced by different AC isoforms regulates unique cellular responses. Overexpression of individual isoforms had distinct effects on forskolin (Fsk)-induced …
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Systematic Interrogation of the Stiffness-sensitive Transcriptome in Mesenchymal Stromal Cells Reveals an Immunomodulatory LncRNA CYTOR
… expression of nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1) regulons, suggesting that these transcription factors serve as mechanotransducers. In addition, an investigation of long non-coding RNAs reveals that CYTOR contributes to these stiffness-driven changes in gene abundance. …
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Adaptation to environmental stress in the human placenta
… expression of genes associated with the activator protein 1 (AP-1) transcription factor pathway and increased expression of genes involved in cytotrophoblast fusion including the gene dysferlin (DYSF). Upon closer examination we noticed that DYSF had a variant (rs10166384;G/A) at a …
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Ruolo della fosfolipasi C-β1 nel differenziamento miogenico: identificazione di nuovi target nucleari
… pathway elicited by PLC-β1 that modulates Activator Protein-1 (AP-1) activity. Indeed, gel mobility shift assays indicate that there is a c-jun binding site located in cyclin D3 promoter region specifically regulated by PLC-β1 and that c-jun binding activity is significantly increased by …
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A single molecule approach to investigate how AP1 transcriptional regulators find their target sites on DNA
Transcriptional regulator protein family members Activator Protein-1 (AP1) bind to their target site TGAC/GTCA during the normal cell cycle. Their over-expression is linked to the initiation of cancer. Regulating cFos and cJun interactions with AP1 binding sites is a potential cancer therapy …
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Anthraquinone-peptide conjugates as inhibitors of DNA transcription factor binding.
Inhibitors of Activator Protein-1 (AP-1)~ a collective term referring to dimeric transcription factors involved in mediating long term responses to signals that regulate growth control and development~ were designed and synthesised in this study. Truncated peptide sequences of 5-7 residues …
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Batf regulates previously unknown AP-1 target genes to control TH17 differentiation
Activator protein 1: AP-1) transcription factors are dimers of Jun, Fos, musculoaponeurotic fibrosarcoma: MAF) and activating transcription factor: ATF) family proteins that are characterized by a basic region and a leucine zipper domain. While many AP-1 proteins also contain defined …
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Molecular Mechanisms Governing Persistent Induction of Pro-Inflammatory Genes by Lipopolysaccharide
… the persistent induction of LCN2 requires both activator protein-1 (AP-1) and CCAAT/enhancer binding protein delta (C/ebpδ). Interleukin-1 receptor-associated kinase 1 (IRAK-1) is critical for LCN2 expression. In the second study, the molecular mechanisms governing the persistent induction of …
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Sevofluran hemmt die DNA-Bindung des Transkriptionsfaktors Aktivator Protein-1 und induziert Apoptose in T-Lymphozyten
Inhalationsanästhetika verursachen in vitro eine veränderte Sekretion von IL-1beta;, TNF-alpha;, IL-8 und IFN-gamma; (32). Der molekulare Mechanismus ist unbekannt. <br>Hypothese dieser Arbeit war, dass Desfluran, Isofluran und Sevofluran über <br>eine Beeinflussung der DNA-Bindungsaktivität von …
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Investigation of the host-mediated proteolytic response to pulmonary Mycobacterium Avium Complex infection
… disease is driven by host-derived matrix metalloproteinases (MMPs). Unlike Mycobacterium tuberculosis (MTb) infection, the mechanisms of tissue destruction during MAC infection are not well-characterised. Here, I aim to elucidate if MMPs are upregulated during MAC infection, and how MMP …
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Molecular mechanisms of radiation-induced brain injury
… of pro-inflammatory transcription factors (e.g., activator protein-1 (AP-1),nuclear factor-κB (NF-κB), and cAMP response element-binding protein (CREB)) and overexpression of pro-inflammatory mediators (e.g., tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and monocyte chemoattractant …
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Effect of Cigarette Smoke Exposure on Bronchial Hyperresponsiveness in Mice and Response to a Corticosteroid and/or a β2-Adrenergic Agonist and Effect of Cigarette Smoke Extract on Cytokines Release from U937 Cells.
… of glucocorticoid receptors β, increase in activator protein-1 (AP-1), and increase in Th-2 cytokines (IL-4 and IL-13), and diminished histone deacetylase-2 activity are attributed to corticosteroid resistance. Since smoking is the primary risk factor of COPD and most of the patients with …
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In vivo and in vitro regulation of plasminogen activator inhibitor type-1
… producing a mixture of active tissue plasminogen activator (t-PA) and urokinase (u-PA) to producing active u-PA alone. I performed a series of experiments designed to examine the mechanism of down regulation of t-PA activity that occurred with differentiation. The results of these experiments …
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The role of sphingosine kinases and dihydroceramide desaturase in cell survival/apoptosis and inflammation pathways
… a mechanism involving p38 mitogen-activated protein kinase (MAPK), oxidative stress, and Mdm2 (E3 ligase) in HEK293T cells.;The polyubiquitinated forms of Degs1 acquire a 'gain of function' and activate pro-survival pathways, p38 MAPK/c-Jun N-terminal kinase (JNK), and X-box protein 1s …