Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 869 for “"Activator"”.
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AFAP-110 is a cSrc activator
The cSrc oncogene directs the reorganization of the actin cytoskeleton in both normal and transformed cells. Mutation of protein binding domains (SH2 and SH3) from cSrc results in the deregulation of the kinase and the transformation of cells, while deletion of these domains blocks transformation …
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Soluble urokinase plasminogen activator receptor in venous ulcers
… to better treatments.<br/>Urokinsae plasminogen activator receptor (uPAR), a GPI anchored 3‐domain<br/>protein exists either attached to cell wall or in soluble forms (suPARI‐III, suPARI<br/>& suPARII‐III fragments). Cleavage of uPAR results in a number of nonproteolytic<br/>functions that may be …
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Post-transcriptional regulation of vibrio cholerae virulence activator toxt
… is the primary virulence gene transcription activator. Once ToxT is produced, it amplifies its own expression through an auto-regulatory loop and directly binds and activates expression of various virulence factors including the toxin-coregulated pilus (TCP) and cholera toxin (CT). During the …
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Structure and Function Analysis of a Plant Transcription Activator
… can function as an as-1-specific transcription activator in a HeLa cell in vitro system as well as a wheat germ in vitro system. In both systems, TGA1a stimulates transcription by increasing the number of preinitiation complexes. When microinjected into cotyledon cells of transgenic tobacco …
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Mechanistic studies of nitrile hydratases and their activator proteins
… and Co-type NHase require a metallochaperone or ‘activator’ protein for maturation to the fully functional state. Through spectroscopy, crystallography, and computational methods, this research elucidates key mechanistic features and provides novel insights into the NHase post-translation …
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Coordinated of Post-Translational Modifications of Yeast Transcriptional Activator Gcn4
Gcn4 is a transcriptional activator that regulates amino acid biosynthetic genes in yeast. Gcn4 is expressed under amino acid starvation conditions, and its degradation depends on phosphorylation, by either Pho85 or Cdk8, which triggers its ubiquitination and subsequent proteolysis by 26S …
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Nla28 Activator Modulates σ54-dependent Gene Regulation in Myxococcus xanthus
… σ54, targeted σ54 promoter DNA and corresponding activator proteins in mechanistic and genomic scales. Also, multicellular lifestyle of M. xanthus and natural products derived from myxobacteria are broadly reviewed.My first project has better defined the gene regulatory networks of M. xanthus in …
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Single molecule investigation of transcription activator-like effector search dynamics
… accessibility of gene engineering. Transcription activator-like effectors (TALEs) are one such class that form a powerful gene-editing platform when fused to nuclease domains, thereby yielding TALEN systems. Despite pervasive use of TALENs for editing crops, small animals, eukaryotic stem cells, …
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The distribution of plasminogen activator in the male genital tract
… (Lombardo, 1957), is due to the release of this activator into the blood stream (Fearnley, 1965). Human semen contains a substance which can activate the blood fibrinolytic system (von Kaulla and Shettles, 1953). Indeed, when human seminal fluid is ejaculated, it undergoes a process resembling …
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Design and control of a closed-loop brushless torque activator
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1990.
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Localization and Stability of the Transcriptional Activator Gcn4p of Saccharomyces cerevisiae
Die `Allgemeine Kontrolle der Aminosäurebiosynthese` der Hefe Saccharomyces cerevisiae ist ein gut charakterisiertes regulatorisches Netzwerk, welches die ausreichende Aminosäureversorgung des Organismus gewährleistet. Dieses System wird durch Stimuli wie beispielsweise Aminosäuremangel, …
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Mechanistic Studies of the Roles of the Transcriptional Activator ExsA and Anti-activator Protein ExsD in the Regulation of the Type Three Secretion System in Pseudomonas aeruginosa
… factor family, is the main transcriptional activator of all the genes necessary for expression of the T3SS. Members of the AraC family are characterized by the presence of two helix-turn-helix (HTH) motifs, which bind to the promoter DNA and activate transcription. ExsA uses its HTH …
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Interaction of Bacteriophage Mu Middle Transcription Activator Protein Mor with Promoter DNA
… Pm requires the 129-amino acid transcriptional activator Mor, a product of early transcription, and the Escherichia coli RNA polymerase. The Pm promoter has a recognizable -10 hexamer but lacks a -35 hexamer. Mor binds as a dimer to an imperfect dyad-symmetrical element containing two 6-bp …
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Regulation of SPARC Gene Expression by the Activator Protein 1 Transcription Factor
<p>Overexpression of the c-Jun proto-oncogene in MCF7 breast cancer cells results in a variety of phenotypic changes related to malignant progression including a shift to estrogen independent growth, increased cell motility and invasion. Concurrent with these phenotypic changes are alterations to …
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Biochemische und funktionelle Untersuchungen der Transposase des Activator-Elements aus Zea mays
Das Ac-Element aus Zea mays, das zur Familie der hAT-Elemente gehört, codiert für ein einzelnes Protein, die Transposase (TPase). Dieses Protein ist in vivo als einziges essentiell für die Transposition von Ac notwendig. Die Expression der TPase in E. coli war bisher nur in unlöslicher Form …
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Generation of novel small molecules as inhibitors of plasminogen activator inhibitor-1
<p>Plasminogen activator inhibitor (PAI-1) is a member of the serine protease inhibitor (serpin) family of proteins, which inhibits certain serine proteases, such as tissue-type plasminogen activator (tPA) and urokinase-type plasminogen activator (uPA), and thus is a primary regulator of …
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Engineering of transcription activator-like effector nucleases (TALENs) for targeted genome editing
… my efforts on engineering transcription activator-like effector (TALE) nucleases (TALENs) as an efficient tool for targeted genome editing. Targeted genome engineering relies on the introduction of a site-specific double-strand break (DSB) in a pre-determined genomic locus by a …
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Characterization of a plasminogen activator from human melanoma cells cultured in vitro
… isolation and characterization of a plasminogen activator, Mel-PA, that is released by human melanoma cells cultured in vitro. This enzyme was compared to the urinary plasminogen activator, urokinase. The human melanoma cell line, RPMI-7272, (also referred to as the "Bowes" melanoma cell line) …
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In vivo and in vitro regulation of plasminogen activator inhibitor type-1
… producing a mixture of active tissue plasminogen activator (t-PA) and urokinase (u-PA) to producing active u-PA alone. I performed a series of experiments designed to examine the mechanism of down regulation of t-PA activity that occurred with differentiation. The results of these experiments …
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