Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Activation- induced Deaminase"”.
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In vitro diversification of chimeric human/chicken antibodies
… cycle-regulated, nuclear restricted version of Activation Induced Deaminase AID that yields high rates of mutations in chimeric human/chicken antibodies. To conclude, a new and promising approach for antibody evolution in DT40 was developed. The new system posed new challenges that were …
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The Loss Of Genomic Uracil Homeostasis And Aid-Dependent Accumulation Of Dna Damage In B Cell Lymphomas
<p>Activation-induced deaminase (AID) is a sequence-selective DNA cytosine deaminase that introduces uracils in immunoglobulin genes. This DNA mutator is required for somatic hypermutation and class switch recombination- processes involved in the affinity maturation and diversification of …
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Genetic and biochemical studies of human apobec family of proteins
… that while all three enzymes are strong cytosine deaminases, only APOBEC3A (A3A) is an efficient deaminator of 5mC. The partially purified A3A converted 5mC to T in vitro as well. This is the first report of efficient deamination of 5mC by any enzyme from any organism. Although AID did not …