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Showing 1 to 5 of 5 for “"Actinoplanes sp."”.
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Sigma factor engineering for natural product synthesis in Actinoplanes sp. SE50/110
… by its natural producer, the soil bacterium *Actinoplanes* sp. SE50/110. While the acarbose biosynthesis (*acb*) gene cluster and the respective pathway have been extensively studied over decades, key regulatory elements for the understanding of acarbose biosynthesis and global transcriptional …
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Genomics and transcriptomics of the industrial acarbose producer Actinoplanes sp. SE50/110
Actinoplanes sp. SE50/110 is known as the wild type producer of the alpha-glucosidase inhibitor acarbose, a potent drug used worldwide in the treatment of type-2 diabetes mellitus. As the global incidence of diabetes is rapidly rising, an ever increasing demand for diabetes drugs, such as acarbose, …
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Detektion und Überexpression von Genen FADH2- abhängiger Halogenasen aus Actinoplanes sp. ATCC 33002
Actinoplanes sp. ATCC 33002 produziert ein fünffach chloriertes Phenylpyrrolderivat, das Pentachlorpseudilin[1], für dessen Biosynthese die Beteiligung FADH2-abhängiger Halogenasen vermutet wurde. Ziel dieser Arbeit war es deshalb, in Actinoplanes sp. nach Genen FADH2-abhängiger Halogenasen zu …