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Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 1012 for “"Actin"”.
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Identification of Actin Binding Proteins Associated with Cross-Linked Actin Networks
Mills, Christy E., Identification of Actin Binding Proteins Associated with Cross-Lined Actin Networks. Master of Science (Pharmacology and Neuroscience), December 2006, 95 pp., 9 tables, 16 figures, references, 122 titles. Glucocorticoid therapy can leady to ocular hypertension and glaucoma. The …
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The Role of Actin Depolymerizing Factor in Regulating Actin Dynamics in Toxoplasma gondii
… Gliding and invasion are dependent on parasite actin filaments, yet parasite actin is mostly non-filamentous. Filaments have been detected only transiently during gliding, suggesting that parasite actin filaments are rapidly assembled and disassembled during gliding motility. Little is known …
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Bitesize bundles F-actin and influences actin remodeling in syncytial Drosophila embryo development
Actin networks undergo rearrangements that influence cell and tissue shape. Actin assembly and organization is regulated in space and time by a host of actin binding proteins. Despite the importance of these processes, their regulation is not well understood. The Drosophila Synaptotagmin-like …
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Actin dynamics in the cell cytoplasm and the role of actin associated proteins
Thesis (Ph.D.)--Harvard--Massachusetts Institute of Technology Division of Health Sciences and Technology, 1998.
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Measuring actin dynamics in endothelium
Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Mechanical Engineering, 1994.
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Actin remodeling in motile cells
… on the dynamics and distributions of cytoplasmic actin. In cells, actin cycles between monomeric and polymeric phases tightly regulated by actin binding proteins that control cellular architecture and movement. Here, we characterize actin remodeling in shear stress stimulated endothelial cells and …
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Mapping the actin and actin binding proteins interactions : from micromechanics to single molecule force spectroscopy
… models describing cell behavior. Filamentous actin (F-actin), as one of the major constituents of the cytoskeleton, has been the target of extensive in vitro studies to determine its mechanical properties in bulk. However, there is still a lack in the understanding of how the molecular …
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Multi-Modal Regualtion of Actin Networks
<p>Eukaryotic cells employ the actin cytoskeleton to maintain cell shape, support motility, and sense and respond to external mechanical stimuli. An intricate network of actin filaments constitutes the foundation of tissue architecture by forming key cellular structures including the muscle fiber, …
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On the depolymerization of actin filaments
Actin is one of the most abundant and highly conserved proteins in eukaryotic cells. The globular protein assembles into long filaments, which form a variety of different networks within the cytoskeleton. The dynamic reorganization of these networks - which is pivotal for cell motility, cell …
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Material properties of actin filament bundles
Actin is an ubiquitous structural protein fundamental to such biological processes as cell motility and muscle contraction. Our model system is the acrosomal process of the Limulus sperm which extends a 60 ýtm long actin bundle during reproduction. It is an example of a biological spring where the …
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Mechanical properties of F-actin network
… surroundings through cytoskeletal dynamics. Actin, the most abundant protein found in eukaryotic cells, is organized into various cytoskeletal structures that provide physical support for the cell and play important roles in numerous cellular processes. Assembly of F-actin into higher-order …
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Dynamics and statics of actin assemblies
… where a 60 [mu]m-long crystalline bundle of actin filaments, tightly cross-linked by actin bundling protein scruin, straightens from a coiled conformation and extends from the cell in five seconds. This spring-like mechanism represents a third type of actin-based motility that is distinctly …
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Giant vesicles compressed by actin polymerization
Actin polymerization plays a critical role in generating propulsive force to drive many types of cell motility. The discovery of actin based motility of the bacterial pathogen Listeria monocytogenes has lead to clearer understandings of the essential ingredients required for cell motility. The …
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Morphology and Mechanics of the Actin Cytoskeleton
… is made of filamentous proteins, such as F-actin, and provides for structural support for the cell. Lamellipodia are extensions of the cellular cytoskeleton at the leading edge of a crawling cell generated so that the cell can extend, and thereby move in a particular direction. In the first …
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Effect of oncomodulin on cytoskeletal actin dynamics.
… to sound. Regulation of filamentous and globular actin may contribute to the reversible shape changes critical to OHC function. Previous studies have suggested that the Rho family of GTPases play an important role in regulating intracellular actin dynamics in OHCs using RhoA/ROCK and LIMK/cofilin …
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A biochemical investigation of actin disassembly mechanisms
The dynamic nature of the actin cytoskeleton enables the rapid shape changes that are necessary for processes such as wound healing, motility and division of cells. Disassembly of actin filaments is extremely critical for the reorganization of cell shape. The cell possesses several factors that …
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Toca-1 driven actin polymerisation at membranes
Regulation of the actin cytoskeleton is key to cellular function and underlies processes including cell migration, mitosis and endocytosis. Motile cells send out dynamic actin protrusions that enable them to sense and interact with their environment, as well as generating physical forces. Linking …
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Effector-driven actin reorganisation restricts Salmonella invasion.
… into the cytosol of the cell and manipulate the actin cytoskeleton, driving pathogen entry. Two of the delivered effectors, namely SopE and SopE2, activate host Rho GTPases and subsequently the Arp2/3 complex, which results in actin reorganisation. Whereas the role of SopE in promoting bacterial …
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Simulation of actin cytoskeleton structure and rheology
Structures consisting of G-actin or other filament-forming monomers show a variety of morphologies with widely different properties in regard to pore size, degree of isotropy, and extent of cross-linking. These characteristics are primarily determined by the concentration and feature of proteins …
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