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Showing 1 to 20 of 36 for “"Acrolein"”.
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The pathological role of acrolein in experimental autoimmune encephalomyelitis and multiple sclerosis
… beneficial. Recently, our lab has implicated acrolein, a highly reactive aldehyde that is both a byproduct and catalyst of lipid peroxidation, as a potential therapeutic target and biomarker for MS diagnosis and symptom monitoring. We have shown that acrolein is elevated in clinical MS cases …
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The partial oxidation of propene to acrolein over single-crystal Cu₂O
The partial oxidation of propene (CH₂=CHCH3) to acrolein (CH₂=CHCHO) has been studied over Cu₂0(100) and (111) single crystal surfaces. Propene adsorption under ultrahigh vacuum conditions yields no significant oxidation products, but the propene desorption temperatures are sensitive to the …
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Myeloid-Specific ARNT Signaling Drives Sex-Based Differences in Acrolein-Induced Pulmonary Toxicity
… in modulating the pulmonary immune response to acrolein, a highly reactive environmental toxicant. Using a murine model with myeloid-specific overexpression of Arnt-a (homolog of human ARNT isoform 1), this study characterizes both the both the initiation (24-hours) and resolution (5-day) phases …
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Acrolein as a novel therapeutic target for spinal cord injury induced neuropathic pain
… clear. We have recently demonstrated that acrolein, a product and catalyst of lipid peroxidation, induces a vicious cycle of oxidative stress, amplifying its effects and perpetuating oxidative stress and inflammation. In the current study, we have confirmed that acrolein is elevated …
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Wirkung des Ballastwasser-Biozids Acrolein auf verschiedene pathogene Bakterienstämme in Meer-, Brack- und Süßwasser
… sich mit der Frage, welche Wirkung das Biozid Acrolein auf verschiedene pathogene Bakterien hat. Vor dem Hintergrund der IMORichtlinie 125 [53] wurde im Ballastwasser-Übereinkommen von 2004 fest gelegt, dass Schiffe ihr Ballastwasser vorbehandeln müssen, bevor es ausgepumpt werden darf. Diese …
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THE IMPACT OF ACROLEIN ON LUNG FUNCTION: EXPLORATION OF NITROSATIVE STRESS-INDUCED LUNG INJURY AND THERAPEUTIC APPROACHES
Acrolein is an environmental and occupational toxicant known to cause adverse health effects to humans in areas such as the respiratory system, ocular system, and the skin. The NIH’s Chemical Counter-Measures Research Program has taken an interest in acrolein as a toxicant because of the lack of …
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Silica nanoparticles as vehicles for therapy delivery in neurological injury
<p>Acrolein, a very reactive aldehyde, is a culprit in the biochemical cascade after primary, mechanical spinal cord injury (SCI), which leads to the destruction of tissue initially unharmed, referred to as "secondary injury". Additionally, in models of multiple sclerosis (MS) and some clinical …
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Validation of Passive Air Sampling Monitors Onboard United States Navy Submarines
… active air sampling methods when sampling for acrolein, formaldehyde and ozone in the enclosed submarine atmosphere. Acrolein monitors containing 2-hydroxymethylpiperidine (HMP) impregnated glass fibers and 2-HMP silica gel as sorbent media, formaldehyde monitors containing adsorbing media of …
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Partial oxidation of α-olefins over iron antimony oxide catalysts
… catalyst for the partial oxidation of propene to acrolein and the oxidative dehydrogenation of 1-butene to 1,3- butadiene. It has become the preferred catalyst for the industrial acrolein formation from propene. The main purpose of this work was to investigate the influence of catalyst parameters …
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Diels-Alder Reactions of 5-[Methoxypoly(Oxyethylene)]-(3E)-1,3-Pentadiene
… (Ib). Diels-Alder reactions of Ia and Ib with acrolein, maleic anhydride, and diethyl acetylenedicarboxylate have been performed. The products of these reactions have been analyzed by spectroscopic techniques. The Diels-Alder adducts of Ia with maleic anhydride and acrolein are converted …
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The identification, purification and characterization of the fetal rat liver glutathione S-transferase isoenzyme YcYfetus
… effect of the GSH S-T substrate and teratogen, acrolein, on this fetal isoenzyme was investigated and compared with acrolein's effect on some of the adult rat liver GSH S-T isoenzymes in the standard 1-chloro-2,4-dinitrobenzene assay. Surprisingly, acrolein was identified as a non-competitive …
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The Synthesis of Lauraceae Lactones: Obtusilactones, Litsenolides, and Mahubanolides
… with phenylselenenyl chloride. Addition to acrolein, followed by oxidation and selenoxide elimination gave the corresponding (alpha),(beta)-unsaturated esters bearing a 1-hydroxy-2-propenyl group at the (alpha)-carbon. Similarly, addition to propargylaldehyde followed by oxidative work-up …
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Airway Inflammatory States in Response to Environmental Pollutants and the Influence of Oxidative Balance
… inflammatory enhancement. Sulfite and acrolein were utilized in vitro to test the ability of pollutants generate reactive oxygen species and initiate allergic inflammation in mast cells. Sulfur dioxide was then employed to translate the in vitro findings into a whole animal model. …
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Identification and Quantification of Protein Carbonylation by Mass Spectrometry
… by the LPO-relevant a, b-unsaturated aldehydes, acrolein (ACR) and 4-hydroxy-2-nonenal (HNE). The investigation is focused on the characterization and quantification ACR and HNE addition to the model proteins. A correlation between HNE modification and ACO activity is also determined. These …
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Photoelectrons and Recombining Electrons in Atomic and Molecular Systems
… the photoionization of low symmetry molecules, acrolein and the singly halogenated thiophenes, due to resonant and non-resonant electron rescattering dynamics. In Chapters 5-6, the disentanglement of the valence electronic structure, as well as evidence for low-energy shape resonances, of the …
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Reaktivität ungesättigter organischer Substrate gegenüber dem TripodCobalt(I)-Templat (Tripod = CH3C(CH2PAr2)3)
… vom Substitutionsmuster des Aldehydes. Während Acrolein und seine alpha-substituierten Derivate in THF stabile [TripodCobalt(hapto4-Heterodien)]+-Verbindungen bilden, sind analoge Komplexe von beta-substituierten Derivaten weniger stabil und reagieren unter Decarbonylierung des Aldehydes und …
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Neue Allyl- und Oxo-Verbindungen des Molybdäns: Synthese, Struktur und Eigenschaften
… durchgeführten Oxidation von Propen zu Acrolein (SOHIO-Verfahren) postuliert als Intermediat pi-Allyl-Mo(+V/+VI)-Komplexe in einer sauerstoffreichen Umgebung. Thema der vorliegenden Arbeit ist die Synthese von Verbindungen, die ein solches Intermediat strukturell modellieren können. Die …
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Cycloaddition-fragmentation mediated pathways to ring D modified 19-norsteroids
… of the dienyl acetate and selected dienophiles (acrolein and methyl vinyl ketone) gave after hydrolysis of the bridgehead ester, substrates which underwent [3,3]sigmatropic rearrangement to generate a series of 14β-perhydrobenzo[14,15]-17-ketones.
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A valence bond for several perturbations
… First order perturbation theory is applied to acrolein, gyloxal, acrylonitrile and methyl butadienes to study inductive effects. These molecules are iso-pi-electronic with butadiene. First and second order perturbation theory is applied to chloroprene, bromoprene, iodoprene and …
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From molybdenum based model catalysts to technically applied systems
… So wird die Partialoxidation von Acrolein zu Acrylsäure an einem solchen System durchgeführt. Zum besseren Verständnis der Genese des Systems wurden Untersuchungen anhand von Modellverbindungen durchgeführt, die nur Molybdän und Sauerstoff enthalten. In Abhängigkeit von den …
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