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Showing 1 to 8 of 8 for “"AcrAB-TolC"”.
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Computational Study on MFP MexA in MexAB-OprM and RND transporter AcrB in AcrAB-TolC Efflux Pumps
… and E.coli / Salmonella, MexAB-OprM and AcrAB-TolC respectively. In particular, we studied the possible multimerization of the MFP component MexA and the effects of mutations in the AcrB distal binding pocket. The starting point for the first part of our study was the uncertainty about …
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The role of AcrA in the antibiotic resistance and virulence of Salmonella enterica serovar Typhimurium
… component of the major efflux system AcrB-TolC of \(Salmonella\) Typhimurium. AcrA of S. \(Typhimurium\) SL1344 was inactivated and the mutant phenotype characterised. RT-PCR and western blotting were used to confirm expression of \(acrB/AcrB\) was retained in the acrA mutant. The AcrA …
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The effects of nutrient limitation and growth rate on the regulation of the multi-drug pump genes acrAB in escherichia coli
… by the gàne products of the multi-drug ef flux acrAB-tolC operon. The primary regulation of acrAB has been investigated in these studies and it has been established by chemostat culture that the expression of acrAB was inversely related to growth rate, and this was irrespective of the limiting …
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Molecular recognition, in- and out- of equilibrium, in the actions of bacterial multidrug efflux nanomachines
… efflux pumps present in bacterial lineages, the AcrAB-TolC assembly in Escherichia coli is one of the best studied efflux machines for conferring intrinsic multidrug resistance. This assembly is a representative of a wide family of homologous and analogous nanomachines, including those found in …
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From gut microbiome to pathogen genomics: Understanding antimicrobial resistance in Southeast Asia and Salmonella Paratyphi A
… linked to mutations in the acrB gene of the AcrAB-TolC efflux system. The impact of these mutations on resistance mechanisms was explored, highlighting their contribution to the growing threat of resistance in typhoidal Salmonella. Among the 132 AMR genes identified in the human gut of a …
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Structural and Mechanistic Studies of Multidrug Resistance Efflux Pumps in Multiple Families
… of the most well-studied drug efflux complexes: AcrAB-TolC. Though numerous structures exist for this multi-protein assembly, none have been obtained without use of detergents that displace natural lipids which may be needed to support key allosteric states. To better characterize lipid …
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Assay Setup for High Throughput Screening to Identify Novel Efflux Pump Inhibitors against Escherichia coli
… efluksipumppu on kolmiosainen AcrAB-TolC-proteiinikompleksi, joka ulottuu koko soluseinärakenteen läpi, pumpaten solun sisältä solunulkoiseen tilaan laajan kirjon rakenteellisesti toisistaan poikkeavia yhdisteitä, aiheuttaen lopulta ristilääkeaineresistenssiä useammalle eri …
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On the Structure and Function of Multidrug Efflux Pumps
… protein called AcrZ with the tripartite complex AcrAB/TolC, in connection with the lipid environment, and the resulting changes in the latter’s functionality (Chapter 2). A regulatory role of the native membrane lipid environment as well as of small proteins for efflux pump activity have …