Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Acidic Cluster"”.
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Functional Characterization of the HIV-1 NEF Acidic Cluster
… of CD4 downregulation, rely in part upon Nef's acidic cluster which has been reported to affect Nef's redirection of cell surface MHC-I to the trans-Golgi network by binding to the cytosolic adapter phosphofurin acidic cluster sorting-1 (PACS-1) (19, 147). Because Nef is potentially significant …
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Identifikation des Transportproteins PACS-1 als Nephrocystin-interagierendes Protein
… SH3-Domäne, einer Coiled Coil-Domäne und zweier Cluster an sauren Aminosäuren (Acidic Cluster). <br>Wir konnten zeigen, dass die Interaktion von PACS-1 mit Nephrocystin die sog. Furin-Bindungsregion von PACS-1 und das erste Acidic Cluster von Nephrocystin benötigt und sowohl in transfizierten …
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Autosomal dominante polyzystische Nierenerkrankung : der Transport von Polyzystin 2 wird phosphorylierungsabhängig von PACS-1 reguliert
… die eine Ansammlung saurer Aminosäuren (Acidic Cluster) im Carboxylterminus von Polyzystin 2 erkennen und an dieses Motiv binden. Die Interaktion zwischen den Adapterproteinen und Polyzystin 2 ist abhängig von einer Phosphorylierung der Bindungsdomäne durch die Protein Kinase CK2. Ein …
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Platelet Dense Granules Mature Within Late Stages Of Megakaryocyte Differentiation By Cargo Delivery
… vital fluorescent dyes to distinguish mildly acidic DGs from highly acidic compartments in platelets and MKs. In mouse platelets, compartments labeled by mepacrine — a fluorescent weak base that accumulates in DGs — are readily distinguishable from highly acidic compartments, likely lysosomes …
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Genetics and functions of the SARS coronavirus spike protein
… by incorporating single point mutations, cluster-to-lysine and cluster-to-alanine mutations, as well as carboxyl terminal truncations into the protein and investigating these mutants in transient expression experiments. Mutagenesis of either the coiled-coil domain of the S glycoprotein …
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Regulation of lipid signaling at the Golgi by the lipid phosphatases hSAC1 and OCRL1
… splice variant containing an extra 8 amino acid acidic cluster is found only in a subset of late endosomal/ lysosomal membranes. This distinct localization of OCRL1 splice variants indicates that each isoform might regulate different trafficking routes by regulating PI(4,5)P2 levels at these …
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Novel Roles of PACS-1 Within the Nucleus and the Regulated Secretory Pathway
PACS-1 functions are explored in three linked sections: the investigation of PACS-1 nuclear trafficking, the impact of PACS-1 on calcium homeostasis, and PACS-1 regulation of membrane protein trafficking within the regulated secretory pathway. First, our results establish PACS-1 motifs that …