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Showing 1 to 20 of 31 for “"Acid labile"”.
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Endogenous and exogenous control of polymers for spatiotemporally defined drug delivery
… control of drug delivery. First, a novel acid-labile liquid polymer responsive to endogenous pH conditions was synthesized and characterized for releasing poorly soluble drugs as an injectable depot, a photo-crosslinked implantable matrix, temporarily stable nanodroplets and stable …
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Biocompatible polymeric nanoparticles for drug/DNA delivery using biologically friendly polymerisation processes
… model networks (CSPMNs) equipped with both acid-labile and non-degradable cores to study potential drug release in acidic conditions. The synthesis of the neutral star polymer precursors to the CSPMNs are also documented. This chapter includes the encapsulation and release of rhodamine B dye …
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Synthesis of sila-analogs and silicon-containing derivatives of drugs and development and application of the Si-2,4,6-trimethoxyphenyl moiety as a novel protecting group in organosilicon chemistry
… (Si-2,4,6-TMOP) moiety is described as a novel, acid-labile protecting group in organosilicon chemistry. The synthesis of chlorotris(chloromethyl)silane and tris(chloromethyl)methoxysilane is described.
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Stereoselective synthesis of piperidines
… ii alkylidenated resin-bound esters i to give acid-labile resin-bound enol ethers iii. These were cleaved to give amino ketones iv. The switch in the nature of the resin from acid-stable to acid-labile is key to the purity of the amino ketones iv, as during cleavage only the acid-sensitive enol …
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An Investigation of Acetobacter aceti N5-Carboxyaminoimidazole Ribonucleotide Mutase and Its purE-purK Operon
… aceti</italic> oxidizes ethanol to acetic acid. While the membrane-permeable acetic acid is toxic to many bacteria, A. aceti survives exposure to acetic acid by tolerating cytoplasmic acidification. The ability to tolerate an acidic cytoplasm suggests that proteins from A. aceti are …
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Study of the reaction of nitriles with dialkyl phosphites for synthesis of a-Amino-bis-phosphonates
… these compounds involved the use of protic acids, which don’t provide ideal conditions for the starting materials containing acid labile functional groups in pharmaceutical compounds. The present study adopts a new synthetic route in which diethyl phosphite addition to the nitrile would be …
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ORGANOCATALYTIC HALOFUNCTIONALIZATION OF OLEFINS
… range of substrates including those which are acid labile. Lastly, preliminary results for the development of a novel proline-based amino-selenocarbamate catalysts were discussed. A derivative of the catalyst, the amino-selenoether, produced encouraging enantioselectivty for halolactonization …
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Synthesis and characterization of pH/temperature dual sensitive multiblock copolymer for drug delivery
… gelation at body temperature and degradation at acidic pH for controlled drug delivery applications. The MBCP with molecular weight of 42000 Da was synthesized by polycondensation between an acid-labile ketal linker, 2,2-bis(aminoethoxy)propane (BAP) and Pluronic® P104 using L-lysine diisocyanate …
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Design and synthesis of handles for solid-phase peptide synthesis and convergent peptide synthesis
… releases C-terminal peptide amides upon acidolysis. Since the FAL handle is acid labile it is compatible with Fmoc and N<sup>α</sup>-dithiasuccinoyl (Dts) based chemistries, but not N<sup>α</sup>-tert-butyloxycarbonyl (Boc) based chemistries. The solid-phase linkage was investigated based …
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Active Center Studies on Bacterial Luciferase: Modification of the Enzyme With 2,4-Dinitrofluorobenzene
… aldehyde and FMNH(,2) to yield the carboxylic acid, FMN and blue-green light. The enzyme is inactivated by 2,4-dinitrofluorobenzene (FDNB) with an observed second-order rate constant (k(,2(obs))) of 157 M('-1) min('-1) at pH 7.0, 25(DEGREES); activity is not recovered upon treatment with …
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Mössbauer studies of putidaredoxin
… weight of 12,000, two atoms each of iron and acid labile sulfur. We have used the Mossbauer effect to study the symmetry of the ligands and the electronic configuration of the iron. These studies were facilitated by the removal of the iron and subsequent replacement with iron-57. Our main …
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Methodologies For Attaching Polypyridyl Ligands Into Amino Acids And Synthesis And Biological Evaluation Of Novel Light Activated Peptidomimetic Cysteine Protease Inhibitors Caged By Ruii(bpy)2
… polypyridyl ligands into unnatural amino acids. The first chapter describes the different possibilities for attaching metal ligands to peptides and their applications as potential imaging and therapeutic agents covered so far in the literature. It is followed in the second chapter by the …
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The structure of trifolitoxin : A bacteriocin from Rhizobium leguminosarum biovar trifolii strain T24 / by Benjamin James Lethbridge.
… (HVPE), enzymatic, Edman sequencing, amino acid analysis and hydrolyses techniques, trifolitoxin has been shown to consist of a linear peptide (MW=1037 (FAB MS)) (asp-ile-gly-gly-ser-(arg-X-gly)-cys-val-ala (Edman/partial hydrolysis)). It contains two UV absorbing chromophores. One is an …
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Essais de purification de l'insulin-like growth factor binding protein-3 (IGFBP-3) bovine
… complex with one IGF peptide and a single acid-labile subunit. The IGFBP-3 purification would allow the measure of the changes in plasma IGFBP-3 throughout the day and the development and in various physiological situations. We try to purify the bovine IGFBP-3. Firstly, we load 0,5 ml of …
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Photoelectromechanical synthesis of low-cost DNA microarrays
… in a site-selective manner, thereby cleaving acid-labile dimethoxytrityl protecting groups with the spatial selectivity that is required for in-situ DNA synthesis. This platform has the potential to be particularly low-cost since it employs standard phosphoramidite reagents, visible wavelength …
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The role of respiration-dependent proton translocation in the acid tolerance of Gluconobacter oxydans
Gluconobacter oxydans is characterized by extreme acid tolerance and the ability to carry out rapid, single-step polyol oxidation catalyzed by membrane bound ehydrogenases. Experiments were designed to determine whether acid tolerance is associated with rapid polyol oxidation in this organism. …
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Liposome drug delivery systems for anticancer agents
… PEG-lipid, PEG<sub>2ooo</sub>-Hz-DHG, with an acid-labile hydrazone linker between the PEG<sub>2ooo</sub> head group and the lipidic DHG moiety was synthesized. PEG<sub>2000</sub>-Hz-DHG was relatively stable at normal physiological pH 7.4, but hydrolyzed more quickly at tumor interstitium pH …
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Cell Wall/Surface Proteome of Candida albicans: its Application in Rapid Identification of Yeast Species by Mass Signature and Characterization by in vitro and in vivo Chemical Labelings
… SILAC (Stable Isotope Labeling by Amino acids in Cell Culture) based CWP quantification analyses were performed to monitor CWP accumulation level change in response to hyphae induction. Information on surface exposed peptide segments and regulation of cell wall/surface protein during …
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Development of novel polymeric architectures for applications in drug delivery and studies towards the synthesis of perfect polymers by iterative exponential growth "Plus" (IEG+)
… drug delivery. Specifically, a series of novel acid-cleavable bisnorbornene crosslinkers were synthesized and evaluated as building blocks for the formation of acid-degradable brush-arm star polymers (BASPs) via the brush-first ring-opening metathesis polymerization (ROMP) method. A …
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Studies on the carbon monoxide dehydrogenase enzyme complex present in acetate-grown Methanosarcina thermophila strain TM-1
… contained 2.8 ± 0.56 Fe atoms and 1.98 ± 0.12 acid-labile sulfide. UV-visible absorption maxima were 395 and 295 nm with a A₃₉₅/A₂₉₅ ratio range of 0.80 to 0.88. The N-terminal amino acid sequence revealed a 4-cysteine cluster, similar to other Fe:S centers that coordinate a Fe:S center. A …
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