Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 6 of 6 for “"Acid Sensing ion channels"”.
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ACID-SENSING ION CHANNELS: TARGETS FOR NEUROPEPTIDE MODULATION AND NEURONAL DAMAGE
Acid-sensing ion channels (ASICs) are proton-gated channels expressed in neurons in the central and peripheral nervous systems. These ion channels are sensors for extracellular pH and contribute to a variety of normal functions including learning and memory, seizure termination, fear, anxiety, and …
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Investigating neural responses in models of neurocysticercosis
… of the world due to high levels of brain infections by larvae of the pig cestode Taenia solium, a condition termed neurocysticercosis. Despite the large nature of the problem, little is known about how neurocysticercosis modulates neuronal responses to result in the development of seizures. In …
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Characterisation of human enteroendocrine cells in organoid models
… response to a meal by regulating digestion, absorption, circulating nutrient availability and satiety. EECs are specialised endocrine cells scattered throughout the gastrointestinal epithelium that release hormones in response to a wide range of luminal and systemic signals. This thesis …
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Functional and behavioural characterisation of C. elegans acid-sensing DEG/ENaCs
… that can form proton-sensitive homomeric channels when expressed in vitro in Xenopus oocytes. These could be further clustered into two groups based on their response to neutral and low pH in vitro: One group that is inhibited by increasing concentrations of protons (ACD-5 and DEL-4, as …
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CHEMICAL APPROACHES TOWARD NEW PERSPECTIVES IN DRUG DISCOVERY: NATURAL PRODUCTS AND BIOACTIVE HITS AS AN INSPIRATION
… innovative molecule design and targeted modifications, this Ph.D. thesis aims to provide different approaches to the conceptualization and development of hypothetical therapeutic agents. Part I of this work delves into the invaluable role of natural products as intrinsically interesting compounds …
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Swarna Ramaswamy_Thesis
<p>STRUCTURAL INVESTIGATIONS OF LIGAND GATED ION CHANNELS</p> <p>Swarna Ramaswamy, B.S</p> <p>Advisor: Vasanthi Jayaraman, Ph.D.</p> <p>Ion channels form an integral part of membrane proteins. In the nervous system including the central and the peripheral nervous system, ligand gated ion channels …