Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 7 of 7 for “"Acetyllysine"”.
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N⁶-formylation of lysine : a pathological secondary modification of proteins
… similarity to the biologically important N⁶- acetyllysine has raised questions about its mechanisms of formation and biological consequences. Using novel ultrasensitive and specific liquid chromatography-coupled tandem mass spectrometry methods (LC-MS/MS) to quantify N⁶-formyllysine lesions in …
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Quantitative approaches to probe the acetylproteome
… degenerate peptide arrays as well as develop acetyllysine affinity reagents as an alternative to anti-acetyllysine antibodies. Additionally, bioorthogonal proteomics were employed to identify acetyltransferase substrates. Taken together, the knowledge generated and the methods developed …
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Expanding the genetic code of a mouse
… (Davis and Chin, 2012) In this study, I used Acetyllysine(AcK) as unnatural amino acids, N? -acetyl-lysyl-tRNA synthetase (AcKRS) as AcK-tRNA synthetase, pyrrolysyl-tRNA(PylT) as tRNA from Methanosarcina mazei (Mukai et al., 2008). Amber codon was inserted in GFP that is role of reporter gene. …
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Mechanistic Enzymology Of Plasmodium Falciparum Sir2, Structural And Biochemical Studies On Nicotinamidases And The Structure And Function Of Enzymes In The Purine Degradative Pathway From Klebsiella Pneumoniae
… shown to be an NAD+-dependent deacetylase and an acetyllysinedependent and acetyllysine-independent NAD+ glycohydrolase. In addition, several examples of the Sir2 modulating enzyme, nicotinamidase, are characterized both structurally and biochemically. These works provided additional insights into …
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Using Statistical Techniques and Machine Learning to Assess Potential Biomarkers and Clinical Characteristics for Differences between Chronic Hepatitis C Virus and Hepatocellular Carcinoma
… Laurylcarnitine, N4-acetylcytidine, N6-acetyllysine, Octadecanedioate, Oleoylcarnitine, Pantoprazole, and Xylitol.
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Role of P300 Zz Domain In Chromatin Association and Histone Acetylation
… on histone H3K27 and H3K18, whereas the acetyllysine binding activity of BRD is required for acetylation of virtually all lysine residues in H3 and H4 tails.</p> <p>p300/CBP are frequently mutated or dysregulated in many human diseases including cancer. We found that p300 is overexpressed …
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Control of Regulatory Element Function by Histone H3.3
… promoters, along with reduced enrichment of the acetyllysine reader BRD4. Despite the enrichment of H3.3 at both promoters and enhancers, it appears to play distinct roles at these regions. ESCs lacking H3.3 or HIRA are able to maintain both accessibility and TF footprinting at enhancers, but …