Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 32 for “"Acetylcholinesterase (AChE)"”.
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Bioaffinity-based Concept for Glyphosate Detection
… This study looks into the interaction between acetylcholinesterase (AChE) and glyphosate, specifically its potential suppression. The study optimizes parameters such as pH levels, enzyme concentrations, and substrate concentrations using the Ellman enzymatic assay. AChE activity is best …
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Studies on the nature of red blood cell hemolysis on storage and the nature of the red blood cell membrane acetylcholinesterase
… evidence in favour of the view that the acetylcholinesterase (AChE) of the red blood cells (RBC) is concerned with the maintenance of the integrity of the cells Anderson and Pethica (9) have reported that in stored citrated blood, the release of RBC ^ChE seemed to coincide with the onset …
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Examining the binding of humanin and acetylcholinesterase with amyloid beta
… protects against its deleterious effects while acetylcholinesterase (AChE) bound to Aβ peptide, increases aggregation and cytotoxicity of Aβ fibrils. Here, we set out to examine factors that regulate the interactions of Aβ with HN and AChE. We found that ATP, known to decrease misfolding of Aβ, …
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Observing the effects of acetylcholinesterase and brain-derived neurotrophic factor on the levels of soluble amyloid precusor protein α in lung cancer cell media
… that media from H1299 cells have lower levels of acetylcholinesterase (AChE) and intact amyloid-β40/42 (Aβ), and higher levels of mature brain-derived neurotrophic factor (mBDNF) when compared to A549 cell media. In conjunction to this the levels of soluble amyloid precursor protein α (sAPPα) were …
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Methods for controlling two European Honey bee (Apis mellifera L.) pests: Varroa mites (Varroa destructor, Anderson and Trueman) And Small hive beetles (Aethina tumida)
… into A. tumida pharmacology, several known acetylcholinesterase (AChE) inhibitors and three novel insecticides (previously shown to have low mammalian toxicity) were tested against an A. tumida laboratory colony through in vivo and in vitro bioassays. The results of these bioassays indicated …
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Exploiting muscarinic acetylcholine receptors as an insecticidal target to enhance the toxicity of gamma-amino butyric acid channel blockers and the continued challenges with resistance
… to muscarinic compounds, type I pyrethroids, and acetylcholinesterase (AChE) inhibitors. In the case of acetylcholinesterase, the resistant insect increases the expression of Ace gene encoding this enzyme. Fully understanding how the CNS responds to receptor modifications is not well understood …
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Molecular, Biochemical, and Toxicological Evaluation of Anticholinesterases for control of the Malaria Mosquito, Anopheles gambiae
… differences between insect and vertebrate acetylcholinesterase (AChE) as well as selectivity and toxicity testing of new carbamate insecticides on Anopheles gambiae, the African malaria mosquito. AChE gorge pharmacology data revealed differences between insect and vertebrate AChE that can …
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Sublethal effects of an acetylcholinesterase-inhibiting pesticide on fitness-related traits in the western fence lizard (Sceloporous occidentalis)
… and personal lawns and gardens. Currently, acetylcholinesterase (AChE)-inhibiting pesticides are among the most prevalently used chemical pesticides in the United States. A wealth of information exists on sub-cellular responses of organisms, primarily birds, mammals, and fish, exposed to …
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Functional Characterization of the C-terminal Cholinesterase-Like (ChEL) Domain of the Thyroid Hormone Precursor Protein
… (ChEL) domain, which bears 47% similarity to acetylcholinesterase (AChE). Mutations in Tg cause congenital hypothyroidism, the most common congenital endocrinopathy affecting 1 in 2,000-4,000 newborns, with a varying degree of phenotypic manifestations. Tg protein, regulated by TSH, is …
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Mild and Convenient Methods to Prepare N-Alkyl Tacrines
… of neuropsychiatric and behavioral disturbances. Acetylcholinesterase inhibitors (AChEI) are the mainstay for the treatment of AD. Acetylcholinesterase (AChE) catalyzes the hydrolysis of acylcholinesters with a relative specificity for acetylcholine (ACh). Observation of a deficiency of …
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Interactions between anticholinesterases in an in vitro central nervous system preparation
… These compounds rapidly inhibit the enzyme acetylcholinesterase (AChE), causing overstimulation within the cholinergic nervous system. If left untreated, this can be fatal. Current medical countermeasures to nerve agent poisoning consist of pretreatment with pyridostigmine and an emergency …
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Postnatal development of brainstem cholinergic inputs to the dorsal lateral geniculate nucleus of the domesticated ferret, Mustela putorius furo
… is relatively absent from interlaminar zones. Acetylcholinesterase (AChE) labeling in the dLGN shows a similar ontogenetic pattern and time course. Retrngrade labeling of brainstem cholinergic nuclei demonstrates that these inputs are in place in the dLGN after the second postnatal week. Thus, …
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Neurochemical Effects of Concurrent Exposure to Repeated Stress and Chlorpyrifos on the Central Nervous System
… On day 28, blood samples were collected for acetylcholinesterase (AChE) activity. Brains were dissected into hippocampus (HP) and cerebral cortex (CC) to determine activities of acetylcholinesterase (AChE), carboxylesterase (Cbxy), and choline acetyltransferase (ChAT), and glutamate and …
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A study of the neurotoxicity of MPTP and analogs in human neuroblastoma SH-SY5Y cells
… and nicotinic receptors. MPTP also inhibited acetylcholinesterase (AChE) activity and increased choline levels. The MPTP-induced increase in DA release and the decreases in catecholamines in SH-SYSY cells were blocked by pretreatment with acetylcholine receptor antagonists atropine and …
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The lethal and sublethal effects of aldicarb on the estuarine grass shrimp, Palaemonetes pugio
… in the grass shrimp was examined using an acetylcholinesterase assay. Acetylcholinesterase (AChE) activity was reduced in the larvae after exposure to acute concentrations of aldicarb. Mean whole-body AChE activity for the newly hatched and 22-d larvae was significantly lower from the …
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Neuromuscular Junctions in Androgen Sensitive Muscles: A Model for Synaptic Plasticity
… abundance of the various molecular forms of acetylcholinesterase (AChE) in muscles of the zebra finch. Castration causes a large decrease in AChE activity but has little or no effect on the relative abundance of AChE forms. This is in marked contrast to the effect of denervation, which causes …
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ANALYTICAL APPLICATIONS OF SURFACE-MODIFIED FUSED SILICA CAPILLARIES
… nerve agents by immobilizing fluorescent labeled acetylcholinesterase (AChE) to the surface and using evanescent waves to monitor the enzyme activity. The hypotheses for the chemical sensor are that the improved enzyme activity of a recombinant AChE, along with the improved sensing capabilities of …
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ANALYTICAL APPLICATIONS OF SURFACE-MODIFIED FUSED SILICA CAPILLARIES
… nerve agents by immobilizing fluorescent labeled acetylcholinesterase (AChE) to the surface and using evanescent waves to monitor the enzyme activity. The hypotheses for the chemical sensor are that the improved enzyme activity of a recombinant AChE, along with the improved sensing capabilities of …
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Palladium uptake and its effect on behavioural and molecular markers in the freshwater shrimp Gammarus pulex
… movement and feeding activity) and biochemical (acetylcholinesterase (AChE); osmoregulation; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide (MTT) reduction; reduced glutathione (GSH); glutathione-S-transferase (GST); thiobarbituric acid reactive substances (TBARS); heat shock …
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Role of the Hu family of RNA-binding proteins in regulating acetylcholinesterase expression in excitatory cells
Post-transcriptional mechanisms regulating acetylcholinesterase (AChE) expression in muscle and neurons are relatively ill-defined, even though several studies have implicated mRNA stability as a means of controlling expression. We have, therefore, undertaken studies examining the role of …
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