Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"Acetyl Coenzyme A"”.
-
Discovery and characterization of regulatory mechanisms affecting the heteromeric acetyl-coenzyme a carboxylase in Arabidopsis
… A staple component of this pathway is the enzyme acetyl-CoA carboxylase (ACCase), which catalyzes the committed step by converting acetyl-CoA to malonyl-CoA. The heteromeric form of this enzyme requires four different subunits for activity: biotin carboxylase, biotin carboxyl carrier protein …
-
Nuclear respiratory factor 1: a novel inhibitor of the human gene promoter of the cardiac isoform of acetyl-coenzyme a carboxylase
… Upstream, the cardiac-enriched isoform of acetyl-CoA carboxylase (ACCl3) synthesises malonyl-CoA, a potent inhibitor of CPT-1 and FA 13-oxidation. Since ACCl3 induction elevates malonyl-CoA levels, we hypothesised that AMPK activates NRF-1 thereby inhibiting ACCl3 expression in the heart to …
-
CHARACTERISING A ROLE FOR ACETYLCOENZYME A SYNTHETASE 2 IN THE REGULATION OF AUTOPHAGY
… role of the central intermediary metabolite acetyl-coenzyme A (AcCoA)for several anabolic and catabolic pathways is well characterised. However, the role of AcCoA as the only known donor of acetyl groups for protein acetylation in regulation of enzyme activities, protein complex stability as …
-
Characterization of the Mechanism of Resistance of a Johnsongrass (Sorghum halepense) Biotype to Selected Graminicides in Virginia and Response of Mugwort (Artemisia vulgaris) to Specific Herbicidal and Cultural Control Strategies
… resistant vs. the susceptible biotype. However, acetyl-coenzyme A carboxylase (ACCase) assays revealed that resistance to the APP and CHD herbicides is conferred by an overproduction of the ACCase enzyme in the resistant compared to the susceptible johnsongrass biotype. In field experiments …
-
Metabolic Regulation of Cellular Signaling
… levels, a subsequent increase in cytosolic acetyl-coenzyme A and activation of Ca2+/calmodulin-dependent protein kinase II (CaMKII). We recently identified coenzyme A (CoA), derived from the breakdown of acetyl-CoA, as the key metabolic signal that mediates a novel mechanism of …
-
3-Hydroxy-3-methylglutaryl-coenzyme A lyase: investigation of cysteines mediating intersubunit disulfide formation and regulation by thiol/disulfide exchange and discovery of an extramitochondrial homolog
3-Hydroxy-3-methylglutaryl-Coenzyme A lyase catalyzes the cleavage of 3-hydroxy- 3-methylglutaryl-Coenzyme A into acetoacetate and acetyl-Coenzyme A, a key reaction in ketogenesis and leucine catabolism. Previous work prompted the hypothesis that in the absence of reductant, cysteine 323 forms a …
-
The glyoxylate shunt as a target for antibacterial intervention in Pseudomonas aeruginosa
… this bacterium metabolises fatty acids into acetyl coenzyme A for biomass production via the glyoxylate shunt. The glyoxylate shunt is comprised of two enzymes: isocitrate lyase and malate synthase G, and allows the synthesis of cellular constituents from C2 nutrient sources, bypassing the …
-
Evaluation And Characterization of Herbicide Resistance In Italian Ryegrass (Lolium multiflorum Lam.) Biotypes To Diclofop-methyl And Alternative Management Options
… crop injury, and acceptable barley yields. Acetyl-coenzyme A carboxylase (ACCase) assays and herbicide absorption, translocation, and metabolism studies were conducted to investigate resistant mechanism(s) to two APP herbicides, diclofop and quizalofop. ACCase assays indicated no differences …
-
Mutational analysis of the human histone chaperone, Nap1, in nucleosome disassembly at the HTLV-1 promoter
… tails. Post-translational modifications, such as acetylation, act to neutralize charges on the histone tails and also serve to create new binding sites for other proteins. These modifications have been associated with decompaction of condensed chromatin, alteration of nucleosome structure, and …
-
Carbon Starvation Metabolically Regulates Chromatin for Transcriptome Rewiring
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Structural and mechanistic investigation towards the regulation of M.tb isocitrate lyase
… the activation of M. tb ICL2 by lipid metabolite acetyl-coenzyme A (acetyl-CoA) and its structural analogues. The interactions between host and pathogen are important for M. tb as the bacteria may reside inside its human host for decades. Human macrophages produce itaconate as an antimicrobial …
-
Modalities of Cholesterol Binding and Modulation of the NPC Proteins and Scap
… these regulatory functions include activation of acetyl-coenzyme A acetyltransferase (ACAT), allowing for esterification of cholesterol for storage, and regulation of sterol regulatory element–binding protein (SREBP) localization, a transcription factor that regulates key enzymes for cholesterol …
-
Yeast engineering for pharmaceutical and nutraceutical purposes
… ethanol pathway plays a key role in cytosolic acetyl-CoA synthesis and redox balance of Saccharomyces, new metabolic engineering approaches not to knock out its ethanol pathway but to minimize the overflow metabolism are needed for increasing productivities of acetyl-CoA derivatives, …
-
Engineering Saccharomyces cerevisiae with enhanced supply of precursor metabolites for efficient production of fuels and chemicals
Made available in DSpace on 2015-09-29T21:03:11Z (GMT). No. of bitstreams: 2 LIAN-DISSERTATION-2015.pdf: 6484498 bytes, checksum: dfafbe7074729b6385dc6f63b3a93fa9 (MD5) LICENSE.txt: 4210 bytes, checksum: 61fac6473db07dd95d79ef7c7ac61659 (MD5) Previous issue date: 2015-07-14