Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 82 for “"Abrogation"”.
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U.S. Abrogation of the I.N.F. Treaty: Implications for Russian-Sino Relations
… this thesis presents the argument that American abrogation of the I.N.F. Treaty would result in strengthened relations between Russia and China if the United States deploys intermediate-range nuclear weapons to the Pacific. Without U.S. deployment, however, the Russian-Sino strategic partnership …
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Abrogation of serine metabolism exacerbates intestinal epithelial inflammation via C/EBPβ-NF-κB pathway
Inflammatory Bowel Disease (IBD) is characterized by chronic inflammation and metabolic dysregulation in the intestinal epithelium. Serine, a non-essential amino acid synthesized via the rate-limiting enzyme phosphoglycerate dehydrogenase (PHGDH), maintains celular redox balance. Serine metabolism …
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Naskh al-Qur'an: A Theological and Juridical Reconsideration of the Theory of Abrogation and Its Impact on Qur'anic Exegesis
… is the theory of naskh, a theory stipulating the abrogation of a verse of the Qur'an by another. The discourse of naskh raises many unsettling theological and legal questions. The present proposed research attempts to reassess the early Muslim understanding of the theory of Qur'anic abrogation. It …
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LELIO BASSO E LA QUESTIONE RELIGIOSA: IL CONCORDATO DEL 1929 E IL SUO SUPERAMENTO.
… in general and his political action about the abrogation or the modification of the 1929’s concordat in particular.
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Unveiling the Headscarf Debate; A Study of Multiculturalism
… this should not serve as a pretext for the abrogation for human rights, except when harm to self or society will result. In order to defend my hypothesis, I will use the case of the headscarf – a controversial piece of cloth that has shaken up governments and societies throughout Europe. …
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The Role of Membrane Domains In Protein and Lipid Sorting During Endocytic Traffic
… is fully sufficient for PM recycling and that abrogation of raft partitioning leads to their degradation in lysosomes. These findings support a model wherein ordered membrane domains mediate PM recycling of membrane components from the endosomal system. The next step was to identify the …
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Molecular Functions of MLL PHD3 Binding to Its Ligands Cyp33 and H3K4Me3
… mutant proteins on MLL target gene expression. Abrogation of H3K4Me3 binding to MLL PHD3 resulted in decrease in transcription of MLL target genes and decrease in H3K4Me3 marks when compared to the MLL-N wt. Also, abrogation of MLL PHD3 binding to H3K4Me3 resulted in decreased expansion of mouse …
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Matriptase Mediated C-Met Signaling In Breast Cancer
… breast cancer cell lines similarly demonstrated abrogation of c-Met signaling upon pro-HGF stimulation. This abrogation of the c-Met signaling pathway affects the breast cancer cells proliferation rate as well as their invasiveness as demonstrated in 3D culture. </p> <p>Our results suggest that …
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Characterization of a novel pro-apoptotic role for nuclear associated BCL-2
… conditions is that they are the end result of abrogation of apoptosis regulation. In the case of stroke, an initial increase in Bcl-2 expression traditionally follows ischemia/re-perfusion. A major goal of stroke therapy is to rescue the peri-ischemic region of cells that have up-regulated …
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Transcription factor antagonism regulates heterogeneity in embryonic stem cell states
… opposing transcriptional and chromatin programs. Abrogation of factor binding to DATEs dampens variation in gene expression, and factor loss alters kinetics of switching between states. These results show antagonism between factors at enhancers results in gene expression heterogeneity and …
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Chromosomal instability and tumorigenesis : genetic analysis of the murine spindle checkpoint gene Mps1
… bipolar attachment to the mitotic spindle. Abrogation of the mammalian spindle checkpoint can cause chromosomal instability (CIN), the frequent gain or loss of entire chromosomes during cell divisions. While CIN has been proposed to be sufficient to initiate tumorigenesis, no direct evidence …
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Proline-rich acidic protein 1 in Life and Death
… of CRC. This is partly mediated through the abrogation of S-phase arrest in a p53 dependent manner, resulting in increased DNA damage and activation of the apoptotic pathway over cell cycle arrest. PRAP also facilitates clearance of apoptotic cells, derangement of which may lead to systemic …
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(Dis)Locations, (Dis) Placements and (Un) Belonging in Zimbabwean White Farmer's Auto/biograhies 1995 to 2010
… the white community’s contestation of the abrogation of their citizenship and mastery in economic production while that legitimacy is queried by counter narratives in the same books. Through poststructuralism, deconstruction and Levinas’s alterity theory, identity and (un)belonging are …
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Dehydroepiandrosterone and dehydroepiandrosterone sulphotransferase activity and expression in human disease
… In this thesis, I have demonstrated that abrogation of DHEA metabolism can result in the manifestation of pathophysiological conditions. SULT2A1 requires 3'-phosphoadenosine-5'-phosphosulfate (PAPS) for catalytic activity. I have identified compound heterozygous mutations in the gene …
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NEW INSIGHTS INTO THE MOLECULAR PATHOGENESIS OF SEVERE FEVER WITH THROMBOCYTOPENIA SYNDROME VIRUS
… in the presence of proteasomal inhibitors, an abrogation in the formation of virally induced vesicles was observed. This abrogation resulted in the previously sequestered signaling components, RIG-I and TBK-1, returning to their canonical localization. Despite achieving normal localization of …
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Abrogated identity : Muslim representation in Hindi popular cinema 1947-2000
… representations and absences result in the abrogation of identity for them as citizens through public culture. But it also sees that the complete disavowal of this cinema is problematic for the Muslim participation in the industry, the possibility of the Muslim spectator pleasurable reading …
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Role of the Type III TGF-beta Receptor Cytoplasmic Domain in Breast Cancer Progression
… <italic>In vitro</italic>, I demonstrated that abrogation of the cytoplasmic domain attenuates the TβRIII-mediated suppression of migration and invasion. TβRIII's suppressive effects are also concomitant with loss of TGF-β signaling, as abrogation of the cytoplasmic domain failed …
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Impact of Tumor Cell Expressed CD38 on Metastasis and Immune Evasion in Breast Cancer
… and metastatic capabilities of hybrid EM cells. Abrogation of CD38 expression triggers an immunostimulatory response thereby preventing the assembly of an immunesuppressive microenvironment in hybrid EM tumors. Moreover, TNBC patient samples harbored tumoral CD38 expression that positively …
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A phagocyte-specific Irf8 gene enhancer establishes early conventional dendritic cell commitment
… RUNX1. Interference with their binding leads to abrogation of Irf8 expression, subsequently to disturbed cell fate decisions, demonstrating the importance of these factors for proper phagocyte cell development. Collectively, these data delineate a transcriptional program establishing cDC fate …
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