Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 24 for “"Abnormal development"”.
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Cell Death as a Morphogenetic Basis for Abnormal Development in Mutant-Bearing and Teratogen-Treated Embryos.
… widespread and essential event during the normal development of many tissues and organs (Glucksmann, 1965). Whole organs may degenerate during normal organogenesis. For example, massive necrosis is necessary for the proper formation of the excretory and urogenital duct systems in vertebrates …
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Some Effects of 6-Azauridine on Two Mutant Genes in the Mouse.
Certain instances of abnormal development may be due to genotype alone or to environment alone. In all likelihood, however, most abnormal development results from an interaction of genotype and environment (Fraser, ’59). The influence of genotype on response to environmental stimuli has been …
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The impact of advanced maternal age on endometrial differentiation and placental development
… aneuploidy in older mothers can be attributed to abnormalities in the oocyte and embryo, however the “Great Obstetrical Syndromes” do not appear to be related to the oocyte and may instead be linked to abnormal development of the placenta. In this thesis, I show that advanced maternal age in the …
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Magnetic resonance imaging and surface-based analysis techniques to quantify growth of the developing brain
… surface within the limited volume of the skull. Abnormal folding of the cerebral cortex in humans is associated with a number of neurological dysfunctions and diseases such as schizophrenia and Williams syndrome. To understand the mechanism of gyrification, and to illuminate the underlying causes …
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First Thirty Days of Life: Examining Calf Behavioral Development in Beluga Whales (<i>Delphinapterus leucas</i>) and Pacific White-Sided Dolphins (<i>Lagenorhyncus obliquidens</i>) at One Zoological Facility
<p>Cetacean development is important for general comparative understanding and the implementation of informed husbandry policies. Due to the inaccessibility of many of these species in the wild, researchers can study managed care populations to better understand basic developmental patterns of …
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Inactivation of the JAK-STAT Pathway
… Aberrant stimulation of this pathway can lead to abnormal development and cellular transformation demonstrating the importance of understanding mechanisms of downregulation. After interferon-γ (IFN-γ) treatment of cells the appearance of tyrosine phosphorylated Stat1 in the nucleus was maximal …
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A characterization of Samuel in terms of the psychological model of Erikson
… by describing both normal as well as abnormal development. His ego-psychology, with its eight-stage developmental plan, its theses and antitheses, is particularly suitable in the case of Samuel, whose life-cycle for the most part can be viewed as problematic, a series of crises. In the …
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The role of E2F·pocket protein repressive complexes in cell cycle control and differentiation
… in cell cycle defects but instead lead to the abnormal development of specific tissues. The lack of a cell cycle phenotype in single mutants could be due to compensation by the other repressive E2F. In order to determine the role that E2F4·pocket protein repressive complexes play in regulating …
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Elucidation of the Role of miR-184 in the Development and Maintenance of the Drosophila Melanogaster Nervous System
… in the Drosophila nervous system throughout development; and has been shown to target key regulators of differentiation, proliferation and apoptosis. Here we identify a novel role for miR-184 in regulating the development and maintenance of the Drosophila melanogaster post-embryonic nervous …
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Plasticity of Brainstem Motor Systems in Response to Developmental Nicotine Exposure
Developmental nicotine exposure (DNE) is known to cause abnormal development of multiple brain regions and results in impaired control of breathing and altered behaviors that rely on proper coordination of the muscles of the tongue. The adverse effects of nicotine are presumably caused by its …
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Designing an interactive information tool for people affected by cancer: My Journey
Cancer is characterised by the abnormal development of cells which possess the capability of destroying normal body tissue. Cancer is devastating due to the capacity to progress at a rapid pace. It is estimated to affect a vast range of people, with 1 in 2 people expected to receive a cancer …
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Identifying the mechanism critical for proliferation, apoptosis, and cell-cell interaction in the development of mouse adrenals and gonads
… different types of knockout models to study the development of Sf1-positive cells in mice. My study is specifically focused on (1) the contribution of adrenal capsular cells to the SF1-positive cortical cells; (2) the maintenance of SF1-positive cells; and (3) the interaction between SF1-positive …
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Development Of Trophoblast Lined Blood Spaces In The Mouse Placenta
… pseudo-vascular spaces in the placenta. Proper development of these maternal blood spaces is crucial for successful pregnancy outcomes. Unlike blood vessels in other organs, the vascular space in placenta is line by non-endothelial TGCs. Previous work in Cross lab has established that there are …
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Studies on Transformation of Tomato(Solanum lycopersicum L.) and Arabidopsis thaliana using Chimerical constructs of varying Tospoviral Origin
… to produce regenerants, 2,419 explants underwent abnormal development on elongation media, 187 failed to root, and 215 plants to be characterized genetically. Of the 215 plants, 9 were from FLA 7804, 96 from FLA 8044, and 110 from MP1. Both PCR and Southern blot hybridization analysis later …
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Carbon-13 magic angle spinning NMR studies of myelin membranes
… fatty acid chain compositions were observed in developmental studies of human myelin, as well as in an abnormal development leukodystrophy, and in multiple sclerosis. Lipid motion in model and myelin membranes was probed by means of variable temperature $\sp{13}$C NMR in the range 37$\sp\circ$C …
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Development of the ocular motor system in mouse embryos
… four of the extraocular muscles. In early development, cranial nerves send pioneering axons into the peripheral tissue surrounding the neural tube. Axons must then respond to exogenous guidance cues to find their muscle targets. Precise axon projections are required, and miswiring or other …
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Defining the role of endonuclease VIII-like 1 and 3 in the repair of interstrand crosslinks in cancer cells
… autosomal-recessive disorder that can lead to abnormal development, bone-marrow failure, and an increased vulnerability to carcinogenesis. Cells derived from FA patients are unusually sensitive to DNA crosslinking agents and it is now known that FA cells lack one of twenty-two known different …
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Synthesis and Biological Investigation into the Metabolism of Retinoids
… which was then observed at stage 36 for signs of abnormal development such as digit duplication. Occurrence of digit duplication would suggest that AT retinol had been metabolised to ATRA, a known inducer of teratogenic effects, within the limb bud; however, only normal development was observed. …
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Modelling neuronal mitochondrial aminoacyl-tRNA synthetase defects
… stress response, and impairment in neuronal development. Furthermore, I investigate how AARS2 mutations associated with two distinct phenotypes impact mitochondrial protein synthesis in neurons in vitro using a non-radioactive technique involving click chemistry. In addition to developing …
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A preliminary investigation of the prevelence of attention deficit hyperactivity disorder and its symptoms in selected Schools in Lusaka Urban
… understanding and scoring children’s normal and abnormal development within the subset. The main finding of this study is that several descriptions in the three subsets seem not to be related to the constructs hyperactivity, impulsivity and inattentiveness. Relating to impulsivity and …
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