Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Abl kinases"”.
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Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity and Cancer
<p>The Abl family of protein tyrosine kinases regulates diverse cellular processes by coordinating cytoskeletal rearrangements. Recent data indicate that pharmacological inhibition of Abl kinases reduces inflammation in preclinical models and in the clinic. While a previous role for Abl kinases in …
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Modelling protein backbone loops using the Monte Carlo method
… systems such<br/>as lysozyme L99A mutant, Bcr-Abl kinases and PDE5 phosphodiesterase<br/>and led to increased sampling of the backbone and more precise free energy<br/>results.
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Procaspase-3 activation as a strategy to overcome resistance to targeted anticancer therapies
… MEK1 and MEK2, are critical gatekeeper kinases in the mitogen-activated protein kinase (MAPK) pathway. Next, I will discuss the prevalence of oncogenic drivers in the MAPK pathway and the development of inhibitors as targeted anticancer therapeutics. Finally, I will explore the prospects …