Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"Abl kinase"”.
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Lariat peptide inhibitors of Abl kinase
A majority of kinase inhibitors predominantly occupy the highly conserved adenine-binding pocket located in the kinase catalytic cleft, and therefore the target selectivity of these molecules is a major concern. In order to design highly specific next-generation drugs, it is essential to exploit …
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Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity and Cancer
<p>The Abl family of protein tyrosine kinases regulates diverse cellular processes by coordinating cytoskeletal rearrangements. Recent data indicate that pharmacological inhibition of Abl kinases reduces inflammation in preclinical models and in the clinic. While a previous role for Abl kinases in …
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Signaling at the Tumor-Immune Interface in Glioblastoma
… signaling using fixation. This approach enables phosphoproteomic profiling of two interacting cell types, capturing dynamic signaling events with cell-type resolution. I applied this method to study co-cultures of glioblastoma (GBM) cells and primary human macrophages. When cultured …
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Expression and function of drug transporters in primitive CML cells
… expression of the oncogenic fusion protein BCR-ABL. The current first line of treatment is imatinib mesylate (IM), a tyrosine kinase inhibitor (TKI) that competes with ATP to block ABL kinase activity, which in turn prevents tyrosine phosphorylation of downstream molecules and selectively …
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Mechanism of regulation of human RAD51 recombinase through post translational modifications & mediator proteins
… phosphorylation. RAD51 is phosphorylated by the cABL tyrosine kinase. The mechanistic and functional significance of this event is largely disputed. Using biochemical and single molecule assays reconstituting major activities of RAD51, I have successfully dissected the biochemical mechanism of …
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Src-Kinasen als Mediatoren Bcr-Abl-induzierter Leukämien
Bcr-Abl, eine onkogene Tyrosinkinase, ist maßgeblich an der Entstehung der chronischen myeloischen Leukämie (CML) sowie einem Teil der Fälle von akuter B-lymphoblastischer Leukämie (B-ALL) beteiligt. Die essentielle Rolle der Kinase-Aktivität von Bcr-Abl für dessen leukämogenes Potential konnte in …
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Investigating a co-operative link between TGF-β and Lyn kinase in Chronic Myeloid Leukaemia
… cells driven by the fusion gene Bcr-Abl. The advent of a mechanism specific kinase inhibitor, Imatinib, targeting the constitutively active Bcr-Abl kinase has paved the way for new treatment strategies. However, resistance emerges, particularly in those in more advanced disease …
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Substratspezifität und Signaltransduktion zellulärer und onkogener Abl-Tyrosinkinasen
Deregulierte Überaktivierung von Tyrosinkinasen der Abl-Familie spielen eine wesentliche Rolle in verschiedenen Leukämieformen beim Menschen. Neben der schon seit vielen Jahren für die CML als ursächlich anerkannten Fusionskinase p210Bcr-Abl sind weitere Fusionskinasen unter Beteiligung der …
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A chromatin-modifying protein is a context-dependent modulator of cell survival in hematopoietic malignancies
… disease progression may result in more amenable drug targets. With this in mind, our group carried out a large-scale RNA interference (RNAi) screen for factors influencing disease progression in a murine model of BCR-Abl+ B-ALL, a disease with low long-term survival rates despite treatment …
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Combination of Dasatinib and Dexamethasone targets the myeloma plasma cell through its interaction with the bone marrow microenvironment
… in chemotherapy, myeloma continues to be incurable and all patients eventually relapse with progressive disease. Cell adhesion mediated drug resistance and a permissive bone marrow microenvironment facilitates myeloma cell survival. Upto 90% of myeloma patients present with bone disease of …
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Generation and Characterization of Human Blood-Brain Barrier Models for Investigating Neuropsychiatric Disorders and Tumor Metastasis
… deficit. The CRKL is a major substrate of the Abl tyrosine kinase, and the Abl/CRKL signaling pathway is critical for endothelial barrier functions. Imatinib, an FDA-approved drug, inhibits Abl kinase and has been used to treat various disorders involving vascular leakages. To test if imatinib …
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Discovery of Dihydroartemisinin and Dasatinib Drug Combination to Cure Pooroutcome BCR-ABL+ Acute Lymphoblastic Leukemia
… by the Philadelphia chromosome-encoded BCR-ABL fusion kinase initiates and drives both Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myelogenous leukemia (CML). Food and Drug Administration (FDA)- approved BCR-ABL-specific kinase inhibitors (BCR-ABL–KIs) …