Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 101 for “"Abl"”.
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Lariat peptide inhibitors of Abl kinase
… useful in identifying and validating new druggable surfaces in the kinase catalytic cleft. These peptides, being larger than small molecules, have the potential to target the ATP binding pocket as well as surfaces that lie adjacent to this pocket. Such peptides recognizing novel binding pockets …
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Substratspezifität und Signaltransduktion zellulärer und onkogener Abl-Tyrosinkinasen
… Überaktivierung von Tyrosinkinasen der Abl-Familie spielen eine wesentliche Rolle in verschiedenen Leukämieformen beim Menschen. Neben der schon seit vielen Jahren für die CML als ursächlich anerkannten Fusionskinase p210Bcr-Abl sind weitere Fusionskinasen unter Beteiligung der …
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Src-Kinasen als Mediatoren Bcr-Abl-induzierter Leukämien
Bcr-Abl, eine onkogene Tyrosinkinase, ist maßgeblich an der Entstehung der chronischen myeloischen Leukämie (CML) sowie einem Teil der Fälle von akuter B-lymphoblastischer Leukämie (B-ALL) beteiligt. Die essentielle Rolle der Kinase-Aktivität von Bcr-Abl für dessen leukämogenes Potential konnte in …
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The Src- and Abl- Dependent Regulation of Net1A In Breast Cancer
… Here we demonstrate that EGF stimulates Src- and Abl1-dependent phosphorylation of Net1A to promote its cytosolic localization. We find that Abl1 efficiently phosphorylates Net1A on Y373, and that phenylalanine substitution of Y373 prevents Net1A cytosolic localization. Aspartate substitution at …
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The analysis of Bcr-Abl—Nox signalling in chronic myeloid leukaemia
… following generation of the chimeric protein Bcr-Abl, a constitutively active tyrosine kinase which induces oncogenesis in part by promoting increased cell survival and proliferation. Since the development of Bcr-Abl-specific tyrosine kinase inhibitors (TKIs) there has been a substantial …
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Roles for C-ABL and P53 in bone homeostasis and DNA damage response
… differentiation defects of mice lacking c-Abl, a p53 interacting protein. We provide evidence that c-Abl, a non-receptor tyrosine kinase, acts at a novel step that affects most cellular events in DNA damage response. c-Abl-/- MEFs showed defects in nuclear foci assembly of adaptor proteins …
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Discovery of Dihydroartemisinin and Dasatinib Drug Combination to Cure Pooroutcome BCR-ABL+ Acute Lymphoblastic Leukemia
… by the Philadelphia chromosome-encoded BCR-ABL fusion kinase initiates and drives both Philadelphia chromosome-positive acute lymphoblastic leukemia (Ph+ ALL) and chronic myelogenous leukemia (CML). Food and Drug Administration (FDA)- approved BCR-ABL-specific kinase inhibitors (BCR-ABL–KIs) …
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Differentially expressed genes in oesophageal cancer : Retinoic acid receptor-ß2, Trio and Abl-related gene
Bibliography: leaves 95-104.
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Bedeutung der Rezeptor-Tyrosinkinase c-Kit in der Pathogenese der, Philadelphiatranslokation Bcr-Abl positiven, chronischen myeloischen Leukämie
… c-Kit mit dem Onkoprotein Bcr-Abl. Es wird in der zeitlichen Abfolge der chronisch myeloischen Leukämie (CML) besonders für die chronische Phase eine Beteiligung des Stammzellfaktors (SCF), dem natürlichen Liganden von c-Kit, an der Proliferation des malignen Zellklons vermutet. …
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Role of the Abelson Tyrosine Kinases in Regulating Macrophage Functions in Immunity and Cancer
<p>The Abl family of protein tyrosine kinases regulates diverse cellular processes by coordinating cytoskeletal rearrangements. Recent data indicate that pharmacological inhibition of Abl kinases reduces inflammation in preclinical models and in the clinic. While a previous role for Abl kinases in …
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Biological Mechanisms and Clinical Implications of Bcr-Abl-Induced Mitochondrial Oxidative Stress and Cell Survival In Chronic Myeloid Leukemia
… active protein-tyrosine kinase BCR-ABL, which is encoded by <em>BCR-ABL</em> fusion gene as the result of chromosome 9/22 translocation (Philadelphia chromosome). Previous studies have demonstrated that oxidative stress-associated genetic, metabolic and biological alterations …
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Aerosols and boundary layer structure over Arctic sea ice based on airborne lidar and dropsonde measurements
… of the atmospheric boundary layer (ABL) and thereby influence the Arctic climate. In the course of this study aircraft measurements were performed over the western Arctic Ocean as part of the campaign PAMARCMIP 2012 of the Alfred Wegener Institute for Polar and Marine Research (AWI). …
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Vitamin D Levels Affect Survival in a BCR-ABL Acute Lymphoblastic Leukemia Mouse Model but Do Not Cause Vitamin-Drug Interactions
<p>It is a well-established phenomenon that dietary components containing CYP3A inducers or inhibitors if co-administered with drugs that are CYP3A4 substrates lead to marked drug-drug interactions. Because vitamin D is known to regulate intestinal CYP3A expression and gut CYP3A expression plays an …
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Frazzled And Abelson Interact To Regulate The Actin Cytoskeleton In Drosophila
… The cytoplasmic tyrosine kinase, Abelson Kinase (Abl) enhances the loss of commissures observed in fra mutant. Abl physically interacts with Frazzled to help guide commissural axons across the midline. Furthermore, the loss of commissural axons is only seen when the actin dynamics are perturbed. …
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Proteasome inhibition in chronic myeloid leukaemia
… to TKI and the emergence of TKI-resistant BCR-ABL mutations. BCR-ABL activity is associated with increased proteasome activity and PI are cytotoxic against CML cell lines. We demonstrate that bortezomib is antiproliferative and induces apoptosis in CD34+ cells taken at diagnosis from patients …
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HEM-protein regulates cell migration and asymmetric cell division during development of the ventral nerve cord in Drosophila melanogaster
… verprolin-homologous protein (WAVE/SCAR) and Abl tyrosine kinase (Abl) mutants, suggesting that these three genes might act together to regulate neuronal migration in the VNC. I have found that Hem is required for maintaining the protein level of WAVE in vivo and is necessary for its proper …
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