Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"Abeta peptides"”.
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Amyloid-beta signaling in physiology and pathology: from astrocytes to SUMO
… molecular culprit in AD is the amyloid-beta (Abeta) peptide, aggregates of which are the main components of the plaques. Numerous studies have implicated soluble Abeta oligomers as the predominant neurotoxic species, although the underlying mechanisms that lead to cognitive failure are not …
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Modeling Peptide-binding Interactions and Polymer-binding Interactions and their Role in Mass Spectrometry
… weight compounds that bind to amyloid beta peptides (Abeta) peptides using electrospray ionization mass spectrometry (ESI-MS). Low molecular weight (LMW) compounds capable of interacting with soluble Abeta may be able to modulate/inhibit the Abeta aggregation process and serve as potential …
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An Insight into Alpha-Synulcien's Biological Function and Its Pathogenesis in Neurodegenerative Disease
… a significant increase in amyloid beta -peptides. Protein quantification of apolipoprotein E (ApoE) a protein that has been associated with the development of Alzheimer's disease, demonstrated a 5-15 fold increase in symptomatic transgenic mice. Ablation of ApoE in alpha -synuclein …
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Structure and activity of human clusterin.
… components, Alzheimer's disease amyloid beta (Abeta) peptides, and apo AI-HDL in addition to immunoglobulins, TGFbeta receptors, heparin and the endocytic receptor LRP2. Little is known of clusterin structure and function. Sequences modeled as amphipathic alpha helices have been proposed as …