Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 3 of 3 for “"Abeta aggregation"”.
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Molecular mechanism of Abeta recognition and neuroprotection by the glycoconjugate beta-sheet-breaker peptide Ac-LPFFD-Th
… To this regard, peptide-based inhibitors of Abeta aggregation have been widely investigated with a particular emphasis to those derived from original amyloid sequences. The experimental work described in the present PhD Thesis aims at outlining the molecular mechanisms underlying the …
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Modeling Peptide-binding Interactions and Polymer-binding Interactions and their Role in Mass Spectrometry
… compounds that bind to amyloid beta peptides (Abeta) peptides using electrospray ionization mass spectrometry (ESI-MS). Low molecular weight (LMW) compounds capable of interacting with soluble Abeta may be able to modulate/inhibit the Abeta aggregation process and serve as potential …
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Incorporation of Cα,α-Disubstituted Amino Acids into Model Peptide Systems: Conformational Analysis and Possible Applications as Therapeutic Agents
… prepared. The effects of AMY-1 and AMY-2 on the aggregation of Aβ were studied, and it was determined that at stoichiometric concentrations, both peptides completely stop Aâ fibrillogenesis. Equimolar mixtures of AMY-1 and Aβ form only globular aggregates as imaged by scanning force microscopy …